Ensaio clínico placebo-controlado com isoflavonas da soja para sintomas depressivos em mulheres no climatério

Sousa, Rilva Lopes de; Filizola, Rosália Gouveia; Diniz, Margareth de Fátima Formiga Melo; Sousa, Eduardo Sérgio Soares; Moraes, João Leonardo Ribeiro de

doi:10.1590/s0100-72032006000200004

Cited by 5 publications

(1 citation statement)

References 28 publications

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“…As for the intensity of depressive symptoms, we observed a reduction in two groups: control and isoflavones, suggesting the existence of a placebo response often reported in clinical trials for the treatment of neuro-vegetative symptoms associated with menopause [22].…”

Section: Discussionsupporting

confidence: 60%

Prospective Memory Assessment, before and after the Use of Concentrated Extract of Soy, in Postmenopausal Women Complaining of Memory Impairment

Vieira¹,

Araújo²,

Haidar³

et al. 2013

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Objective: To evaluate the performance of a sample of postmenopausal women complaining of decline of prospective memory, undergoing therapy with concentrated extract of soy (CES) for six months, through specific neuropsychological assessment, developed for this purpose. Materials and Methods: A randomized and double-blind study was with 90 women, 12-month amenorrhea, 40 years to 65 years and body mass index (BMI) above 30 kg/m 2 , whose complaints were reduction of cognitive efficiency. The participants were randomly divided into two treatment groups: Group I-received one capsule of 150 mg extract of soy, with 60 mg isoflavones orally/day; Group II-received one capsule placebo, for six months. All participants underwent a detailed interview, the MMSE, depression scale, and as they were being included in the study, self-perception scales and neuropsychological tests before and after six months of treatment. For analysis purposes, we applied the ANOVA and t-student tests. Results: Our results suggest a possible positive effect regarding the improvement in verbal fluency and executive function tasks of planning and mental flexibility, in women undergoing therapy with concentrated extract of soy in postmenopause. There was no correlation between prospective memory and cognitive performance, and there were only intensity scores of the depressive symptoms. Conclusion: Isoflavones act favorably on the cognitive function, amongst all functions, only on verbal memory and executive function tasks of planning and mental flexibility. The others showed no signs of improvement. We concluded that concentrated extract acts only on some cognitive functions.

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Section: Discussionsupporting

confidence: 60%

Prospective Memory Assessment, before and after the Use of Concentrated Extract of Soy, in Postmenopausal Women Complaining of Memory Impairment

Vieira¹,

Araújo²,

Haidar³

et al. 2013

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Efficacy of isoflavones in relieving vasomotor menopausal symptoms – A systematic review

Jacobs¹,

Wegewitz

Sommerfeld

et al. 2009

Molecular Nutrition Food Res

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This review assessed the efficacy of isoflavone supplements to reduce vasomotor symptoms in menopausal women by reviewing all published randomized controlled trials. Systematic literature searches were carried out in 70 databases. Randomized and placebo controlled studies were included if they investigated the treatment of isoflavone supplements derived from soy or red clover on vasomotor symptoms in peri- or postmenopausal women for at least 12 wks. Data were analyzed concerning outcome and methodological quality of the study. Twenty-three trials met the inclusion criteria, thereof 17 investigated soy isoflavones and 6 red clover isoflavones. Without exception, selected trials examining the effect of red clover isoflavones were already assessed in several meta-analyses and were therefore excluded from this evaluation. As the soy isoflavone studies were very heterogeneous concerning interventions and outcome measures, meta-analysis could not be performed and trials were systematically assessed in a structured approach. Included soy isoflavone studies had numerous quality deficiencies and did not consistently show a reduction of flushes after treatment with soy isoflavones. Therefore, there is no conclusive evidence, but only some indication of a benefit of soy isoflavones on hot flush frequency or severity.

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Mechanistic interplay of different mediators involved in mediating the anti-depressant effect of isoflavones

Diksha,

Singh,

Bhatia

2023

Metab Brain Dis

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Ensaio clínico placebo-controlado com isoflavonas da soja para sintomas depressivos em mulheres no climatério

Cited by 5 publications

References 28 publications

Prospective Memory Assessment, before and after the Use of Concentrated Extract of Soy, in Postmenopausal Women Complaining of Memory Impairment

Prospective Memory Assessment, before and after the Use of Concentrated Extract of Soy, in Postmenopausal Women Complaining of Memory Impairment

Efficacy of isoflavones in relieving vasomotor menopausal symptoms – A systematic review

Mechanistic interplay of different mediators involved in mediating the anti-depressant effect of isoflavones

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