Vaginose bacteriana e DNA de papilomavírus humano de alto risco oncogênico em mulheres submetidas a conização com alça diatérmica para tratamento de neoplasia intra-epitelial cervical de alto grau

Discacciati, Michelle Garcia; Rabelo-Santos, Sílvia Helena; Campos, Elisabete Aparecida; Simões, J. A.; Derchain, Sophie Françoise Mauricette; Sarian, Luís Otávio; Zeferino, Luíz Carlos

doi:10.1590/s0100-72032004000900008

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Although this difference was not statistically significant, this result is in agreement with findings from other studies in which an association was demonstrated between HSIL, cervical cancer, and BV. 9,15,16 A possible limitation of this study may be that only cytological criteria were used. Neither histological diagnosis of CIN, HPV DNA testing, or microbiological criteria for BV diagnosis was used.…”

Section: Discussionmentioning

confidence: 99%

Is bacterial vaginosis associated with squamous intraepithelial lesion of the uterine cervix?

Discacciati

Simões

Lopes

et al. 2006

Diagnostic Cytopathology

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The objective of this study was to analyze the association between bacterial vaginosis (BV) and squamous intraepithelial lesion (SIL). Pap smears were analyzed to verify the presence of BV and SIL. One hundred and ten women with SIL comprised the study group, while 110 women with no cytological abnormalities served as controls. BV was similarly present in women of both groups: 18% of women with SIL and 12% of women without SIL. Results were also similar when the grade of SIL was taken into consideration. BV was detected in 16% of women with low-grade SIL and in 12% of women in the control group, while a higher rate of BV (33%) was found among women with high-grade SIL in comparison to the controls (12%). This difference, however, was not statistically significant. BV tended to be more common among women with high-grade SIL than in women with no cytological abnormalities.

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Section: Discussionmentioning

confidence: 99%

Is bacterial vaginosis associated with squamous intraepithelial lesion of the uterine cervix?

Discacciati

Simões

Lopes

et al. 2006

Diagnostic Cytopathology

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show abstract

“…Another possibility that might favor evolution of lesions associated with bacterial vaginosis would be changes to vaginal pH, which our study was unable to evaluate, since it was retrospective and our service did not routinely perform evaluations on vaginal pH. 23 With regard to other factors, hormonal contraceptives have been described in the literature as being associated with cell transformation and progression from low-grade to high-grade lesions. 24 This was contrary to what our study observed, in which use of hormonal contraceptives was a protective factor.…”

Section: Amongmentioning

confidence: 93%

A retrospective study on cervical intraepithelial lesions of low-grade and undetermined significance: evolution, associated factors and cytohistological correlation

et al. 2014

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A retrospective study on cervical intraepithelial lesions of low-grade and undetermined significance: evolution, associated factors and cytohistological correlation Estudo retrospectivo sobre lesões intraepiteliais cervicais de baixo grau e de significado indeterminado: evolução, fatores associados e correlação citohistológica ABSTRACTCONTEXT AND OBJECTIVES: Cervical cancer is an important cause of morbidity and mortality throughout the world. There is some controversy about the factors that may be associated with infection by the human papillomavirus (HPV) that may favor or protect against evolution from a low-grade intraepithelial lesion to a high-grade intraepithelial lesion or invasive neoplasia. The objective here was to evaluate the evolution of low-grade intraepithelial lesions and squamous or glandular lesions of undetermined significance, the associated factors and cytohistological correlations. DESIGN AND SETTING: Retrospective study conducted in a public tertiary-level university hospital. METHODS: Information was obtained by reviewing patient records and/or colposcopy reports. A statistical analysis was performed using logistic regression, calculating the odds ratio and applying chisquare tests. RESULTS: Of the 3390 patients, 409 evolved to high-grade intraepithelial lesions, of which 354 had an initial diagnosis of HPV infection, 27 of squamous atypia of undetermined significance, 22 of low-grade intraepithelial lesions with or without cytological diagnosis of infection by associated HPV and six of glandular cell atypia of undetermined significance. CONCLUSIONS: Lactobacillus sp and bacterial vaginosis on the smears, smoking and immunodepression were factors associated with evolution. A single partner, use of hormonal contraceptives, lower parity, age and a cytological diagnosis of cytolytic vaginosis, T. vaginalis, Candida sp or cocci were factors associated with protection. With regard to cytohistological correlation, there was a 74.08% agreement among patients with high-grade lesions and a biopsy obtained during the same period. RESUMO CONTEXTO E OBJETIVOS:O câncer do colo uterino é importante causa de morbidade e mortalidade no mundo. Existem controvérsias sobre fatores que podem estar associados à infecção por papilomavírus humano (HPV) e favorecer ou proteger contra a evolução de lesão intraepitelial de baixo grau até lesão intraepitelial de alto grau ou neoplasia invasiva. O objetivo aqui foi de avaliar a evolução de lesões intraepiteliais de baixo grau e de significado indeterminado, escamosas ou glandulares, os fatores associados e as correlações citohistológicas. TIPO DE ESTUDO E LOCAL: Estudo retrospectivo realizado em hospital universitário público terciário. MÉTODOS: As informações foram obtidas por meio de revisão de prontuários e/ou fichas de colposcopia. A análise estatística foi realizada por meio de regressão logística, calculando-se o odds ratio e aplicando-se o teste qui-quadrado. RESULTADOS: Das 3.390 pacientes, 409 evoluíram para lesão intraepitelial de alto grau, das quais 35...

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Vaginose bacteriana e DNA de papilomavírus humano de alto risco oncogênico em mulheres submetidas a conização com alça diatérmica para tratamento de neoplasia intra-epitelial cervical de alto grau

Cited by 2 publications

References 14 publications

Is bacterial vaginosis associated with squamous intraepithelial lesion of the uterine cervix?

Is bacterial vaginosis associated with squamous intraepithelial lesion of the uterine cervix?

A retrospective study on cervical intraepithelial lesions of low-grade and undetermined significance: evolution, associated factors and cytohistological correlation

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