Associação entre a antropometria e a leptina circulante nos compartimentos materno, fetal e placentário, na gravidez normal

Abstract

(veia: coef 0,007, p=0,02 e artéria: coef 0,006, p=0,02, mas também pode ser produzida em outras locais como placenta, ossos, cartilagens, trato gastrointestinal e cérebro 4,5 . Os níveis de leptina estão aumentados durante a gestação humana e a expressão placentária da leptina, assim como de seus receptores, foi recentemente descoberta 6,7 . Estes estu-

Low Leptin Concentration in the First Gestational Trimester Is Associated with Being Born Small for Gestational Age: Prospective Study in Rio de Janeiro, Brazil

“…3 Confidence interval for overall incidence. the fetus a signal for the expansion of its body fat reserves, being the regulator of fetal weight and growth [22,33,34] . Valūniene et al [35] observed lower concentrations of leptin in the cord blood in SGA newborns.…”

“…The main focus in most of these studies is either the leptin concentrations in the umbilical cord [18][19][20] or the maternal serum concentrations of leptin at the moment of delivery [18][19][20][21] . The variations in circulating concentrations of maternal leptin during gestation seem to play an important role in the construction of the theory of the fetal origin of disease, since it participates in several processes such as fertility control and fetal growth [22,23] .…”