Polimorfismo do gene do receptor de progesterona (PROGINS) em mulheres com endometriose pélvica

Carvalho, Cristina Valletta de; D’Amora, Paulo; Sato, Hélio; Girão, Manoel Joâo Batista Castello; Lima, Geraldo Rodrigues de; Silva, Ismael Dale Cotrim Guerreiro da; Schor, Eduardo

doi:10.1590/s0100-72032004000800004

Cited by 2 publications

(4 citation statements)

References 19 publications

(20 reference statements)

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“…These results run counter to the study conducted in Brazil by Carvalho et al (2004), which revealed PROGINS polymorphism in 33.0% of endometriosis patients and in 21.0% of the control group. This significance was also observed in an Austrian study conducted by Wieser et al (2002), in which this change was noted in 31.6% of patients with endometriosis and 15.0% of healthy individuals.…”

Section: Discussioncontrasting

confidence: 99%

“…The exaggerated expression of estrogen receptors and progesterone receptor defects are consequences of the abnormality of the progestational effect on the endometrium and ectopic topic. Changes in its function may facilitate the emergence of the disease because, in the broad sense, they fail to antagonize the proliferative effects of estrogens (Carvalho et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…The antiproliferative effects of progesterone on the endometrium are mediated by the isoform A and activation of isoform B in the absence of type A receptor leads to increased proliferation in the epithelium (Carvalho et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Polymorphism of the progesterone receptor gene associated with endometriosis in patients from Goiás, Brazil

Rc²,

Ab³

et al. 2011

Genet. Mol. Res.

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ABSTRACT.We investigated a possible link between endometriosis and polymorphism of the progesterone receptor gene (PROGINS). The endometriosis group consisted of 54 patients with a diagnosis of endometriosis by laparoscopy, and the control group comprised 44 women without endometriosis. Genotypes for PROGINS polymorphisms (A1/A1, A1/A2 and A2/A2) were determined by polymerase chain reaction and analyzed on a 2% agarose gel stained with ethidium bromide. The frequency of polymorphic genotypes (A1/A2 and A2/A2) was significantly higher in patients with endometriosis (33%) than in the control group (16%). We Polymorphism of the progesterone receptor gene conclude that there is a significant correlation between PROGINS polymorphism and endometriosis.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Polymorphism of the progesterone receptor gene associated with endometriosis in patients from Goiás, Brazil

Rc²,

Ab³

et al. 2011

Genet. Mol. Res.

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“…The genotypic frequencies observed for the PGR PROGINS polymorphism were comparable to those reported in other studies on Brazilian and non-Brazilian populations ( 12 , 17 , 18 , 29 , 30 ). On the other hand, the genotypic frequencies of the ERα gene polymorphisms were significantly different from those described in most studies from other populations, emphasizing the importance of the population-specific determination of such frequencies ( 2 - 5 , 7 , 31 - 33 ).…”

Section: Discussionsupporting

confidence: 87%

Prevalence of ERα-397 PvuII C/T, ERα-351 XbaI A/G and PGR PROGINS polymorphisms in Brazilian breast cancer-unaffected women

Giacomazzi

Aguiar

Palmero

et al. 2012

Braz J Med Biol Res

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Polymorphisms of hormone receptor genes have been linked to modifications in reproductive factors and to an increased risk of breast cancer (BC). In the present study, we have determined the allelic and genotypic frequencies of the ERα-397 PvuII C/T, ERα-351 XbaI A/G and PGR PROGINS polymorphisms and investigated their relationship with mammographic density, body mass index (BMI) and other risk factors for BC. A consecutive and unselected sample of 750 Brazilian BC-unaffected women enrolled in a mammography screening program was recruited. The distribution of PGR PROGINS genotypic frequencies was 72.5, 25.5 and 2.0% for A1A1, A1A2 and A2A2, respectively, which was equivalent to that encountered in other studies with healthy women. The distribution of ERα genotypes was: ERα-397 PvuII C/T: 32.3% TT, 47.5% TC, and 20.2% CC; ERα-351 XbaI A/G: 46.3% AA, 41.7% AG and 12.0% GG. ERα haplotypes were 53.5% PX, 14.3% Px, 0.3% pX, and 32.0% px. These were significantly different from most previously published reports worldwide (P < 0.05). Overall, the PGR PROGINS genotypes A2A2 and A1A2 were associated with fatty and moderately fatty breast tissue. The same genotypes were also associated with a high BMI in postmenopausal women. In addition, the ERα-351 XbaI GG genotype was associated with menarche ≥12 years (P = 0.02). ERα and PGR polymorphisms have a phenotypic effect and may play an important role in BC risk determination. Finally, if confirmed in BC patients, these associations could have important implications for mammographic screening and strategies and may be helpful to identify women at higher risk for the disease.

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Polimorfismo do gene do receptor de progesterona (PROGINS) em mulheres com endometriose pélvica

Cited by 2 publications

References 19 publications

Polymorphism of the progesterone receptor gene associated with endometriosis in patients from Goiás, Brazil

Polymorphism of the progesterone receptor gene associated with endometriosis in patients from Goiás, Brazil

Prevalence of ERα-397 PvuII C/T, ERα-351 XbaI A/G and PGR PROGINS polymorphisms in Brazilian breast cancer-unaffected women

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