Detecção do DNA do papilomavírus humano após excisão da zona de transformação com alça diatérmica para tratamento de neoplasia intra-epitelial cervical

Figueirêdo, Priscila Garcia; Derchain, Sophie; Sarian, Luís Otávio; Gontijo, Rodrigo Modesto Gadelha; Andrade, Liliana Aparecida De Ângelo; Campos, Elizabete Aparecida; Martínez, Edson Zangiacomí

doi:10.1590/s0100-72032003000100002

Cited by 5 publications

(5 citation statements)

References 18 publications

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“…In this study, the frequency of women treated for SIL and positive for HR-HPV (28%) was similar or higher than those found in Brazil (33% or 22/67 women and 22% or 16/74 women), Korea (18% or 44/243 women) and Belgium (29% or 21/72 women), where women positive for HR-HPV had a high frequency (from 18% to 44%) of recurrence of SIL 16,[28][29][30] . This suggests that post-treatment HR-HPV detection can be a useful tool in the follow-up and guidance of treated women.…”

Section: Discussionmentioning

confidence: 80%

Detección del virus del papiloma humano de alto riesgo por captura híbrida II® según hallazgos citológicos en mujeres tratadas por lesiones escamosas intraepiteliales de cuello uterino, período 2006/2010

Mongelós¹,

Páez²,

Rodriguez-Riveros³

et al. 2013

Rev. bras. epidemiol.

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IntroductionCervical cancer is the third most frequent type of cancer in women worldwide, including 529,828 new cases and 275,128 deaths in 2008, of which 31,712 occurred in Latin America and the Caribbean. A total of 85% of new cases take place in developing countries. The standard incidence rate by age in South America is 24.1 cases/100,000 women. In Paraguay, the incidence and mortality rates are 35.0 and 16.6/100,000 women, respectively. These rates are significantly higher than those recorded in neighboring countries such as Argentina, Brazil, Uruguay and Chile 1 . The human papillomavirus (HPV) is a factor involved in the development of cervical cancer. There are more than 100 types of HPV, of which approximately 40 infect the anogenital mucosa. These are categorized into high-risk viruses (HR-HPV) and low--risk viruses (LR-HPV), according to their oncogenic potential, and the HR-HPV (16,18,31,33,35,39, 45, 51, 52, 56, 58, 59, and 66) account for 95% of all cervical cancer cases [2][3][4][5] . The cytological diagnosis (Papanicolaou test) is a simple low-cost method used to detect the cytopathic effect of this virus, although not determining the viral type. As the HPV does not grow in traditional cell cultures, molecular methods have been recently used to identify the viral genotype, such as the Hybrid Capture II® test (HC-II®), which detects 13 types of HR-HPV and enables the viral load to be estimated 6,7 . There are no treatments that can eliminate an HPV-related infection, they can only remove the lesions produced by this virus. The methods used for this treatment are as follows: Loop Electrosurgical Excision Procedure (LEEP), cryotherapy and cervical conization. Although HPVrelated intraepithelial lesions can be treated, there is a chance of recurrence or even the development of cervical cancer. If the lesion extends to the endocervical surgical margin, the risk of failure is higher. Moreover, women who have lesion-free surgical margins show a risk of treatment failure of 2-6%, regardless of the treatment used. The cumulative rate of invasion eight years after treatment is 5.8 cases/1,000 women, which is five times higher than that of the general population [8][9][10][11][12][13][14] . In addition to considering the compromised surgical margins as a recurrence factor, there are other factors that promote the persistence or recurrence of squamous intraepithelial lesions (SIL) after treatment, such as age, parity, cytological diagnosis and degree of lesion prior to treatment 15 . As a result, a continuous and thorough follow-up is important after the treatment. Recent studies suggest that the combined use of cytology and the HC-II® test increases effectiveness when selecting women at risk of developing residual or recurrent SIL after six months of treatment [16][17][18][19] . In Paraguay, previous studies have observed a high frequency of HR-HPV in women without cervical lesions and cofactors of risk (a high number of sexual partners and multiparity, among others) associated with the development of cerv...

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Section: Discussionmentioning

confidence: 80%

Detección del virus del papiloma humano de alto riesgo por captura híbrida II® según hallazgos citológicos en mujeres tratadas por lesiones escamosas intraepiteliales de cuello uterino, período 2006/2010

Mongelós¹,

Páez²,

Rodriguez-Riveros³

et al. 2013

Rev. bras. epidemiol.

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“…En el presente trabajo la frecuencia de mujeres tratadas por SIL positivas para HR-HPV (28%) fue comparable o mayor a las detectadas en Brasil de 33% (22/67 mujeres) y 22% (16/74 mujeres); Corea del 18% (44/243 mujeres) y Bélgica del 29% (21/72 mujeres), presentando en estos estudios las mujeres positivas para HR-HPV una alta frecuencia del 18 al 44% de recidivas de SIL 16,[28][29][30] . Lo cual sugiere, que realizar la detección de HR-HPV post-tratamiento, podría ser una herramienta útil en el seguimiento y orientación de las mujeres tratadas.…”

Section: Discussionunclassified

Detección del virus del papiloma humano de alto riesgo por captura híbrida II® según hallazgos citológicos en mujeres tratadas por lesiones escamosas intraepiteliales de cuello uterino, período 2006/2010

Mongelós¹,

Páez²,

Rodriguez-Riveros³

et al. 2013

Rev. bras. epidemiol.

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“…Nos dois grupos houve diminuição da freqüência de detecção de DNA de HPV aproximadamente quatro meses após a conização. Estudos anteriores também demonstraram diminuição significativa da detecção de DNA de HPV após tratamento da NIC por conização diatérmica, o que sugere que este procedimento contribui para o desaparecimento do vírus 2,9,19 .…”

Section: Discussionunclassified

Vaginose bacteriana e DNA de papilomavírus humano de alto risco oncogênico em mulheres submetidas a conização com alça diatérmica para tratamento de neoplasia intra-epitelial cervical de alto grau

Discacciati¹,

Rabelo-Santos²,

Campos³

et al. 2004

Rev. Bras. Ginecol. Obstet.

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Detecção do DNA do papilomavírus humano após excisão da zona de transformação com alça diatérmica para tratamento de neoplasia intra-epitelial cervical

Cited by 5 publications

References 18 publications

Detección del virus del papiloma humano de alto riesgo por captura híbrida II® según hallazgos citológicos en mujeres tratadas por lesiones escamosas intraepiteliales de cuello uterino, período 2006/2010

Detección del virus del papiloma humano de alto riesgo por captura híbrida II® según hallazgos citológicos en mujeres tratadas por lesiones escamosas intraepiteliales de cuello uterino, período 2006/2010

Detección del virus del papiloma humano de alto riesgo por captura híbrida II® según hallazgos citológicos en mujeres tratadas por lesiones escamosas intraepiteliales de cuello uterino, período 2006/2010

Vaginose bacteriana e DNA de papilomavírus humano de alto risco oncogênico em mulheres submetidas a conização com alça diatérmica para tratamento de neoplasia intra-epitelial cervical de alto grau

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