Effect of the celexoxib in microscopic changes of the esophageal mucosal of rats induced by esofagojejunostomy

Lima, Austry Ferreira de; Lourenço, Laércio Gomes; Matos, Délcio; Sousa‐Rodrigues, Célio Fernando de

doi:10.1590/s0100-69912014000300010

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2016

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“…Some authors have reported that non-steroid anti-inflammatory drugs promote intestinal healing, while others have shown their deleterious effects on intestinal healing by increasing the rate of anastomotic dehiscence which consequently leads to a higher mortality rate [1][2][3][4] . Also herbal medicines from Amazon region in…”

Section: Introductionmentioning

confidence: 99%

Immediate postoperative evaluation of enteric anastomosis after the use of meloxicam in rats

et al. 2016

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PURPOSE:To compare ileal anastomoses in the immediate postoperative healing period after meloxicam use. METHODS:Forty two male Wistar rats were randomly divided into two groups of 21, COX and control group. To COX meloxicam in combination with morphine was given in 3 days period. Control group received only morphine during the same period. Each group was divided into three sub-groups of 7, which were euthanized at 5, 10, and 21 days postoperatively. Comparison was based in histological evaluation of collagen type I and III using sirius red, immunohistochemical through vascular endothelial growth factor and matrix metalloproteinase-9. RESULTS:Healing process in scheduled periods did not show significant differences (p>0.05) between the COX and control groups during any of the periods. CONCLUSION:The use of meloxicam in the postoperative period following ileal anastomosis did not affect healing.

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Section: Introductionmentioning

confidence: 99%

Immediate postoperative evaluation of enteric anastomosis after the use of meloxicam in rats

et al. 2016

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Effect of the celexoxib in microscopic changes of the esophageal mucosal of rats induced by esofagojejunostomy

Abstract: celecoxib had neither protective nor inducing effect on esophagitis, but had a protective effect on dysplasia of the animals of group I.

Cited by 1 publication

References 23 publications

Immediate postoperative evaluation of enteric anastomosis after the use of meloxicam in rats

Immediate postoperative evaluation of enteric anastomosis after the use of meloxicam in rats

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