Haematological and biochemical characteristics of the splenic effluent blood in schistosomal patients undergoing splenectomy

Petroianu, Andy; Buzatti, Kelly Cristine de Lacerda Rodrigues; Resende, Vívian; Sabino, Kelly Renata

doi:10.1590/s0100-69912014000300007

Cited by 5 publications

(6 citation statements)

References 25 publications

(37 reference statements)

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“…If a patient reaches an advanced age, these haematological conditions will have been adequately controlled without the need for a surgical procedure. Consequently, conservative approaches should continue to be performed [23,24,25] .…”

Section: Splenic Diseases In the Elderlymentioning

confidence: 99%

“…By contrast, in the presence of hyporexia, leukocytosis and fever, a septic disturbance should be considered. Wound, urinary infection and pneumonia are the most probable diagnoses [6,7,23,25] .…”

Section: Postoperative Periodmentioning

confidence: 99%

“…Asplenia is the major risk factor for OPSI with a general incidence of 3.2%, but in elderly patients, this adverse event may occur in more than 10% of all cases with a high mortality rate. The risk of OPSI in patients who undergo conservative spleen procedures is absent or much lower [4,6,23,38] .…”

Section: Postoperative Periodmentioning

confidence: 99%

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The Spleen and Spleen Surgery in the Elderly

Petroianu

2018

International Journal of Hematology Research

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The spleen is a very important organ with many essential functions, not only in the defense of the organism, but also in its metabolic, immunological and haematological systems. The most common manifestations of the splenic disturbances include splenomegaly and a decrease in the number of blood elements. After the removal of the spleen, 2% of adults present severe sepsis, while more than 10% of the elderly are at risk of death due to septic conditions. Most splenic diseases can be treated conservatively. Operative procedures should be considered in special conditions, when all conservative options have been unsuccessfully depleted. Even in the presence of a severe trauma to the spleen or advanced haematological diseases, the best approach is a non-operative procedure. When the operation is unavoidable, partial and subtotal splenectomies or implants of autogenous splenic tissue onto the greater omentum should be performed. At least 25% of a normal spleen should be left with drainage to the portal system to preserve the complete efficacy of all splenic functions. The technological advances and the progressive development of new surgical devices are responsible for laparoscopy with or without robotic assistance. These surgical approaches lead to less pain, faster postoperative recovery and better cosmetic results, without decreasing the therapeutic efficacy. The conservative splenic approach, whether clinical or surgical, is the best way to prevent postsplenectomy infection, by preserving the spleen's role in immunity.

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Section: Splenic Diseases In the Elderlymentioning

confidence: 99%

Section: Postoperative Periodmentioning

confidence: 99%

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The Spleen and Spleen Surgery in the Elderly

Petroianu

2018

International Journal of Hematology Research

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“…In an attempt to maintain at least part of the splenic function when removal of the spleen is indicated, since 1984 we have performed subtotal splenectomy combined with central splenorenal shunt or with portal–variceal disconnection for the treatment of portal hypertension in 129 patients. 1 , 2 , 3 , 4 , 5 , 6 Subtotal splenectomy has also been used by us to treat 93 patients with severe splenic trauma, 7 , 8 eighteen patients with myeloid metaplasia, 9 nine patients with Gaucher's disease, 10 five patients with retarded growth and sexual development associated with splenomegaly, 11 three patients with severe splenic pain due to extensive intraparenchymal thrombosis, 12 one patient with a splenic hemangioma, 13 one patient with a splenic abscess 14 and one patient with a cystadenoma of pancreatic tail. 15 …”

mentioning

confidence: 99%

“…On the basis of our previous experience with subtotal splenectomy and of the literature that indicates partial splenectomy to control leukemia, a subtotal splenectomy was associated to the oncological treatment. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 …”

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confidence: 99%

Subtotal splenectomy for the treatment of chronic lymphocytic leukemia

Petroianu

2015

Blood Cancer Journal

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Splenectomy is associated with sexual dysfunctions and decreased libido

Sabino

Petroianu

2021

Sci Rep

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The removal of the spleen due to disease or trauma may be followed by disorders due to the asplenism, including immunodeficiency, hematological and metabolic diseases, mainly dyslipidemia, which can lead to sepsis, pulmonary embolism and early death. Although patients frequently report sexual disinterest after splenectomy, this feature has been experimentally studied only in a translational investigation performed by the same group of this work. To study libido and other sexual functions after the complete removal of the spleen in humans. This study was performed on 60 healthy adults, 30 men and 30 women, after more than 1 year of total splenectomy to treat isolated splenic trauma. The International Index of Erectile Function was applied to men and the Female Sexual Function Index to women. The analysis compared the responses obtained in the periods before and after the splenectomy. Laboratory tests with hematological and biochemical analyses, including sex hormones, were performed in all patients. The pre- and postoperative results were compared in each group using the paired t-test, with each patient being his or her own control and with significance to p < 0.05. A decrease in libido and an increase in sexual dysfunction was observed after splenectomy in all men and women, p < 0.001. All postoperative laboratory tests showed normal values in both genders. Asplenia is associated with a marked decrease in libido and intense sexual dysfunction in both men and women, with normal hematological and biochemical laboratory tests, including hormonal exams.

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Haematological and biochemical characteristics of the splenic effluent blood in schistosomal patients undergoing splenectomy

Abstract: hematological and biochemical values of splenic effluent blood are higher than those found in peripheral blood in the presence of schistosomal splenomegaly. However, the splenic blood effluent is not sufficient to raise the blood levels found after splenectomy.

Cited by 5 publications

References 25 publications

The Spleen and Spleen Surgery in the Elderly

The Spleen and Spleen Surgery in the Elderly

Subtotal splenectomy for the treatment of chronic lymphocytic leukemia

Splenectomy is associated with sexual dysfunctions and decreased libido

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