Estudo comparativo do uso tópico de própolis verde e vermelha na reparação de feridas em ratos

Batista, Lara Lívia Valença; Campesatto, Eliane Aparecida; Assis, Maria Lysete Bastos de; Barbosa, Alexandra; Grillo, Luciano Aparecido Meireles; Dornelas, Camila Braga

doi:10.1590/s0100-69912012000600012

Cited by 44 publications

(21 citation statements)

References 14 publications

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“…Propolis has been studied due several properties, as antimicrobial, anti-inflammatory, antioxidant, and others [11][12][13][14][15][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. The chemical compounds found in propolis showed antimicrobial and tissue tolerance characteristics.…”

Section: Discussionmentioning

confidence: 99%

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Antibacterial action of red and green propolis extract in infected root canal

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et al. 2017

Rev. Odonto Ciênc. (Online)

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OBJECTIVE: This study investigated the antibacterial action of 30% red propolis, 40% green propolis and 2.5% sodium hypochlorite with irrigation protocols in infected root canals. METHODS: During 60 days, twenty-four root canals were inoculated with E. faecalis. In all experimental groups were performed root canal preparation and two irrigation protocols -passive ultrasonic irrigation and conventional irrigation. In the groups 1, 3, 5 and 7 it were made root canal preparation associated to conventional irrigation with 30% propolis, 40% propolis, 2.5% sodium hypochlorite and distilled water, respectively. In groups 2, 4, 6 and 8 it was made root canal preparation associated with passive ultrasonic irrigation with the solutions described above. The groups 9 and 10 were the controls (negative and positive). Samples of the root canals were collected and immersed in 7 mL of BHI, for 48 hours, at 37ºC. Bacterial growth was analyzed by turbidity of the culture medium. RESULTS: Antibacterial action was observed of 30% red propolis and 2.5% sodium hypochlorite when used passive ultrasonic irrigation and conventional irrigation after 20 minutes, but in 72 hours it was not effective. CONCLUSION: The irrigating agents and protocols were not effective to eliminate the microorganisms of the infected root canals. Clinical Significance: Propolis presents potential for clinical application due to its antimicrobial, anti-inflammatory, antioxidant and low toxicity properties. Key words: Endodontic; Propolis; Sodium hypochlorite Ação antimicrobiana do extrato de própolis vermelho e verde em canais radiculares infectados RESUMO OBJETIVO: Investigar a ação antibacteriana do própolis vermelhos 30%, do própolis verde 40% e do hipoclorito de sódio 2,5% com protocolos de irrigação em canais radiculares infectados. MÉTODOS: Durante 60 dias, vinte e quatro canais radiculares foram inoculados com E. faecalis. Em todos os grupos experimentais foi realizado o preparo do canal radicular e dois protocolos de irrigação -irrigação ultra-sônica passiva e irrigação convencional. Nos grupos 1, 3, 5 e 7 foi feito o preparo do canal radicular associado à irrigação convencional com própolis 30%, própolis 40%, hipoclorito de sódio 2,5% e água destilada, respectivamente. Nos grupos 2, 4, 6 e 8 foi feito o preparo do canal radicular associado à irrigação ultra-sônica passiva com as soluções descritas acima. Os grupos 9 e 10 foram os controles (negativos e positivos). Amostras dos canais radiculares foram coletadas e imersas em 7 mL de BHI, durante 48 horas, a 37ºC. O crescimento bacteriano foi analisado por turvação do meio de cultura. RESULTADOS: Ação antibacteriana foi observada com própolis vermelho 30% e hipoclorito de sódio 2,5% quando utilizado irrigação ultra-sônica passiva e irrigação convencional após 20 minutos, porém, após 72 horas as substâncias não foram efetivas. CONCLUSÃO: Os agentes de irrigação e os protocolos não foram efetivos para eliminar os microorganismos dos canais radiculares infectados.

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Section: Discussionmentioning

confidence: 99%

“…In this regard, propolis has been investigated for presenting antimicrobial properties, anti-inflammatory, antioxidant, and others [11][12][13][14][15][16][17][18][19][20][21][22][23][24]. Because of its low toxicity, it has been studied as possible intracanal medication [11,12].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial action of red and green propolis extract in infected root canal

Endo

Estrela

Alencar

et al. 2017

Rev. Odonto Ciênc. (Online)

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“…An Indian propolis containing flavonoids, phenolic acids and terpenes, topically applied to rats with excision wounds, has upregulated hydroxyproline, hexosamine, uronic acid, nucleic acids and protein levels in wounded tissue, similar to the effect of nitrofurazone (Iyyam Pillai et al, 2010). In addition, in a study on Wistar rats, Brazilian green propolis rich in artepillin C has revealed superior wound healing activity with respect to Brazilian red propolis (Batista et al, 2012). …”

Section: Propolismentioning

confidence: 99%

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

et al. 2017

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Honeybees produce honey, royal jelly, propolis, bee venom, bee pollen, and beeswax, which potentially benefit to humans due to the bioactives in them. Clinical standardization of these products is hindered by chemical variability depending on honeybee and botanical sources, but different molecules have been isolated and pharmacologically characterized. Major honey bioactives include phenolics, methylglyoxal, royal jelly proteins (MRJPs), and oligosaccharides. In royal jelly there are antimicrobial jelleins and royalisin peptides, MRJPs, and hydroxy-decenoic acid derivatives, notably 10-hydroxy-2-decenoic acid (10-HDA), with antimicrobial, anti-inflammatory, immunomodulatory, neuromodulatory, metabolic syndrome preventing, and anti-aging activities. Propolis contains caffeic acid phenethyl ester and artepillin C, specific of Brazilian propolis, with antiviral, immunomodulatory, anti-inflammatory and anticancer effects. Bee venom consists of toxic peptides like pain-inducing melittin, SK channel blocking apamin, and allergenic phospholipase A2. Bee pollen is vitaminic, contains antioxidant and anti-inflammatory plant phenolics, as well as antiatherosclerotic, antidiabetic, and hypoglycemic flavonoids, unsaturated fatty acids, and sterols. Beeswax is widely used in cosmetics and makeup. Given the importance of drug discovery from natural sources, this review is aimed at providing an exhaustive screening of the bioactive compounds detected in honeybee products and of their curative or adverse biological effects.

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“…10,14,15 However, studies about the synthesis of metallic nanoparticles using Brazilian propolis are not available yet. The red propolis is classified as the 13th Brazilian propolis group based on its physicochemical characteristics, 16,17 in special the higher content of phenolic compounds, which gives a series of biological properties already reported in literature scaring properties, [18][19][20] a stabilizer, 14 antibacterial, [21][22][23][24] anti-inflammatory. 20,25,26 Given this information, the present study aimed to evaluate the biogenic synthesis of silver nanoparticles utilizing this Brazilian propolis.…”

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confidence: 99%

Biogenic synthesis of silver nanoparticles using Brazilian propolis

Barbosa

Souza

Alvino

et al. 2019

Biotechnology Progress

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Biological methods have been used to synthesize silver nanoparticles through materials such as bacteria, fungi, plants, and propolis due to their reducing properties, stabilizer role and environmentally friendly characteristic. Considering the antimicrobial activity of propolis as well as the broad‐spectrum antibacterial effects of silver nanoparticles, this study aim to describe the use of Brazilian propolis to synthesize silver nanoparticles (AgNP‐P) and investigate its antimicrobial activity. The synthesis was optimized by factorial design, choosing the best conditions for smaller size particles. AgNP‐P demonstrated a maximum absorbance at 412 nm in ultraviolet‐visible spectra, which indicated a spherical format and its formation. Dynamic light scattering demonstrated a hydrodynamic size of 109 nm and polydispersity index less than 0.3, showing a good size distribution and stability. After its purification via centrifugation, microscopy analysis corroborates the format and showed the presence of propolis around silver nanoparticle. X‐ray diffraction peaks were attributed to the main planes of the metallic silver crystalline structure; meanwhile infrared spectroscopy demonstrated the main groups responsible for silver reduction, represented by ∼22% of AgNP‐P indicates by thermal analysis. Our product revealed an important antimicrobial activity indicating a synergism between propolis and silver nanoparticles as expected and promising to be an effective antimicrobial product to be used in infections.

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Estudo comparativo do uso tópico de própolis verde e vermelha na reparação de feridas em ratos

Abstract: There was no correlation between total flavonoid contents and the healing action of propolis. This reveals the need for elucidation of the flavonoids found in each class of propolis to unravel which one(s) would be important for the healing process.

Cited by 44 publications

References 14 publications

Antibacterial action of red and green propolis extract in infected root canal

Antibacterial action of red and green propolis extract in infected root canal

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

Biogenic synthesis of silver nanoparticles using Brazilian propolis

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