Carcinoma de células de Merkel em extremidade inferior

Almeida, Marcelo Wilson Rocha; Lopes, Catiucia Carneiro; Almeida, Hiram Larangeira de; Costa, Luis Eugênio

doi:10.1590/s0100-69912012000200015

Cited by 5 publications

(4 citation statements)

References 5 publications

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“…O tamanho e profundidade não representam a gravidade ou predizem metástases, no entanto, a localização (tronco e extremidades) e disseminação reduzem a sobrevida 6,9 . No caso, devido a disseminação linfonodal ao diagnóstico, presume-se identificação tardia do CCM 8 .…”

Section: Discussionunclassified

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Linfadenectomia Em Carcinoma De Células De Merkel Avançado

Gritsch¹,

Lucca²,

Ribeiro³

et al. 2021

Relatos Casos Cir.

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Introdução: O Carcinoma de Células de Merkel (CCM), rara neoplasia neuroendócrina de pele, acomete regiões fotoexpostas, com crescimento rápido, caráter agressivo e alta taxa de mortalidade. É diagnosticado por biópsia e imunohistoquímica (IHQ), e o tratamento realizado com cirurgia e terapia adjuvante. Relato do caso: O presente estudo retrata paciente masculino, 74 anos, portador de lesão exuberante em região glútea associada a metástase linfonodal, confirmada por meio de histologia e IHQ de CCM. Submetido a ressecção da lesão, linfadenectomia inguinal aberta e radioterapia (RT). Houve evolução locorregional associada a linfocele, disfunção orgânica múltipla, sepse e desfecho desfavorável. Conclusão: São discutidas a apresentação incomum do caso, sua gravidade, desafios cirúrgicos e complicações.

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Section: Discussionunclassified

“…A QT pode ser indicada nos casos com metástases à distância. O tumor costuma ser sensível à cisplatina, doxorrubicina e fluorouracil 1,6,8 . No caso, apesar de indicada, devido ao falecimento do paciente, não foi instituída a QT.…”

Section: Discussionunclassified

Linfadenectomia Em Carcinoma De Células De Merkel Avançado

Gritsch¹,

Lucca²,

Ribeiro³

et al. 2021

Relatos Casos Cir.

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“…MCC typically presents as a rapid growing (weeks or months) painless violaceous nodule. It usually arises on sunexposed regions, like the head and neck (41%-50%), followed by the extremities (32%-38%) and the trunk (12%-14%) (1,4) . Occurrence in the gluteal region, as observed in this patient, is uncommon, with few cases described in the literature.…”

Section: Discussionmentioning

confidence: 99%

Sarcoidosis simulating metastasis in patient with Merkel cell carcinoma

Chagas

Avó

Maion

et al. 2014

Jornal Brasileiro De Patologia E Medicina Laboratorial

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“…Studies revealed an increase in incidence from 0.15 to 0.44 cases for every 100.000 inhabitants between 1986 and 2001. Around 50% of the patients eventually develop metastatic disease, predilecting the liver, bones and brain [16][17]. The etiology of MCC is still unknown.…”

Section: Possible Neuroectodermic Origin Of Merkel Cellsmentioning

confidence: 99%

Merkel cell carcinoma versus metastatic small cell primary bronchogenic carcinoma

Velez¹,

Jackson²,

Lisette³

et al. 2013

Our Dermatol Online

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Introduction: Merkel cell carcinoma (MCC) of the skin is a rare, aggressive, malignant neuroendocrine neoplasm. The tumor classically demonstrates positive immunohistochemistry (IHC) staining for chromogranin A(ChrA), cytokeratin 20 (CK20), neuron specific enolase (NSE) and/or achaete-acute complex-like 1 (MASH1). The newly identified Merkel cell polyomavirus (MCPyV) has been found to be associated with most MCC cases. The primary histologic differential diagnoses of cutaneous MCC is small cell primary bronchogenic carcinoma (SCLC); moreover, both are of neuroendocrine origin. SCLC accounts for approximately 10-15% of all primary lung cancer cases; this histologic subtype is a distinct entity with biological and oncological features distinct from non-small cell lung cancer (NSCLC). In contradistinction to MCC, SCLC is classically IHC positive for cytokeratin 7 (CK7) and transcription factor (TTF-1). Similar to SCLC, MCC cell lines may be classified into two different biochemical subgroups designated as Classic and Variant. In our review and case report, we aim to emphasize the importance of a multidisciplinary approach to the approach to this difficult differential diagnosis. We also aim to comment about features of the cells of origin of MCC and SCLC; to summarize the microscopic features of both tumors; and to review their respective epidemiologic, clinical, prognostic and treatment features. We want to emphasize the initial workup study of the differential diagnosis patient, including evaluating clinical lymph nodes, a clinical history of any respiratory abnormality, and chest radiogram. If a diagnosis of primary cutaneous MCC is confirmed, classic treatment includes excision of the primary tumor with wide margins, excision of a sentinel lymph node, and computed tomography, positron emission tomography and/or Fluorine-18-fluorodeoxyglucose positron emission tomography scan studies.Key words: Merkel cell carcinoma; thyroid transcription factor; somatostatin; IMP3; small cell lung carcinoma (SCLC) Abbreviations and acronyms: Merkel cell carcinoma (MCC), thyroid transcription factor 1 (TTF-1), immunohistochemistry (IHC), neuron specific enolase (NSE), small cell lung carcinoma (SCLC), chromogranin A(CgA), insulin-like growth factor II mRNA binding protein 3 (IMP3), neurofilament protein (NF), cytokeratin 7 (CK7), cytokeratin 20 (CK20), surveillance, epidemiology, and end results (SEER), non-small cell lung cancer (NSCLC), computed tomography (CT), positron emission tomography (PET), magnetic resonance imaging (MRI), Merkel cell polyoma virus (MCPyV). MERKEL CELL CARCINOMA VERSUS METASTATIC SMALL CELL PRIMARY BRONCHOGENIC CARCINOMA IntroductionMerkel cell carcinoma (MCC) of the skin is an aggressive but rare malignant neuroendocrine tumor. This tumor has a high rate of recurrence and metastasis the main histopathological differential diagnosis is cell lung carcinoma (SCLC). Most MCC are usually positive to cytokeratin 20 (CK20) stain as well as may show some neuroendocrine differentiation, expressing eit...

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Carcinoma de células de Merkel em extremidade inferior

Cited by 5 publications

References 5 publications

Linfadenectomia Em Carcinoma De Células De Merkel Avançado

Linfadenectomia Em Carcinoma De Células De Merkel Avançado

Sarcoidosis simulating metastasis in patient with Merkel cell carcinoma

Merkel cell carcinoma versus metastatic small cell primary bronchogenic carcinoma

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