Avaliação das citocinas IL-10 e IL-13 como mediadores na progressão da fibrose de Symmers em portadores de esquistossomose mansônica na forma hepatoesplênica

Abstract

Evaluation of the cytokines IL-10 and IL-13 as mediators in the Evaluation of the cytokines IL-10 and IL-13 as mediators in the Evaluation of the cytokines IL-10 and IL-13 as mediators in the Evaluation of the cytokines IL-10 and IL-13 as mediators in the Evaluation of the cytokines IL-10 and IL-13 as mediators in the progression of symmers fibrosis in patients with hepatosplenic progression of symmers fibrosis in patients with hepatosplenic progression of symmers fibrosis in patients with hepatosplenic progression of symmers fibrosis in patients with hepatosplenic progression of symmers fibrosis in patients with hepatosplenic schistosomiasis mansoni schistosomiasis mansoni schistosomiasis mansoni schistosomiasis mansoni schistosomiasis mansoni Avaliação das citocinas IL-10 e IL-13 como mediadores na progressão da fibrose Avaliação das citocinas IL-10 e IL-13 como mediadores na progressão da fibrose Avaliação das citocinas IL-10 e IL-13 como mediadores na progressão da fibrose Avaliação das citocinas IL-10 e IL-13 como mediadores na progressão da fibrose Avaliação das citocinas IL-10 e IL-13 como mediadores na progressão da fibrose de Symmers em portadores de esquistossomose mansônica na forma de Symmers em portadores de esquistossomose mansônica na forma de Symmers em portadores de esquistossomose mansônica na forma de Symmers em portadores de esquistossomose mansônica na forma de Symmers em portadores de esquistossomose mansônica na forma hepatoesplênica hepatoesplênica hepatoesplênica hepatoesplênica hepatoesplênica The mean concentrations of IL-10 in ng/mL in serum were GI: 50.0 ± 59.0; GII: 38.0 ± 270; GIII: 38.0 ± 20.0. Concentrations of IL-13 in ng/mL in the serum of patients were respectively: 41.0 ± 93.0 in GI, 16.0 ± 17.0 in GII and 18.0 ± 34.0 in GIII. There was no significant difference between the mean concentrations of IL-10 and IL-13 between the study groups (p> 0.05). Conclusion Conclusion Conclusion Conclusion Conclusion: The mean serum concentrations of IL-10 and IL-13 were similar in all three groups, indicating that possibly the presence of these cytokines in serum is not associated with different degrees of Symmers fibrosis in patients with hepatosplenic schistosomiasis mansoni. . In Pernambuco, the highest prevalence is in the Zona da Mata, often ranging from 10% to 50% of their habitants 3 . The disease presents in various clinical forms, with 5% to 7% of subjects developing serious lesions in liver and spleen, the fibrosis being an important aspect of the infection by Schistosoma mansoni in man 4 . Schistosomal fibrosis is caused by a cellular immune reaction (granuloma) directed against the parasite egg deposited in the liver. The newly formed granuloma is an inflammatory reaction and, when it is poorly controlled by the body, it becomes fibrotic. The formation of the granuloma is mediated primarily by CD4 + T cells, endothelial cells, activated platelets, neutrophils and hepatocytes 5 . Fibrosis happens due to the accumulation of extracellular matrix proteins (ECMPs), for example, lamin...

Low IL-6, IL-10, and TNF-αand High IL-13 Cytokine Levels Are Associated with Severe Hepatic Fibrosis inSchistosoma mansoniChronically Exposed Individuals

“…The current findings are consistent with those from Brazil where a significant association between high IL-13 levels and severe hepatic fibrosis in S. mansoni infected individuals was documented [ 31 ]. On the contrary, no associations were found between this cytokine and the different stages of fibrosis in hepatosplenic patients with S. mansoni infection in another study [ 32 ]. Of interest in the present study was the possible protective role of IL-6 against severe fibrosis.…”

Treatment and education reduce the severity of schistosomiasis periportal fibrosis

“…Thus, understanding the causal factors that can affect the clinical outcome of this disease remains a challenge [11][12][13] . Therefore, this study aims to describe the epidemiological and clinical factors and to evaluate the factors associated with the development of moderate to severe PPF.…”

Receptor Antagonist of IL‐13 Exerts a Potential Negative Regulation During Early Infection of Human Schistosomiasis

“…The main immunopathology resulting from the disease is characterized by chronic granulomatous inflammation , which consists of a delayed hypersensitivity reaction mediated by CD4 + T cells directed against the parasites’ eggs which are retained in the intrahepatic branches of the portal vein and/or are deposited in the liver parenchyma . When this granulomatous reaction is not controlled, the liver becomes fibrotic.…”

“…When this granulomatous reaction is not controlled, the liver becomes fibrotic. The fibrosis process occurs due to excessive accumulation of extracellular matrix proteins (ECMP) in the periportal space, which is characterized as periportal fibrosis (PPF) . Complications due to this PPF, such as portal hypertension, oesophageal varices and gastrointestinal bleeding, are responsible for mortality associated with schistosomiasis mansoni .…”

“…To date, studies have been conducted to evaluate the immune response associated with the process of hepatic fibrogenesis . The responses of Th1 cytokines (IL‐2, IFN‐γ and TNF‐α) are being related to decreased fibrosis in schistosomiasis, while Th2 cytokines (IL‐4, IL‐6, IL‐10 and IL‐13) play a critical function in the pathogenesis of the disease .…”