Efeito da suplementação nutricional com glicina e glutamina, por via oral, na cicatrização colônica em coelhos

Figueiredo, Juliano Alves; Petroianu, Andy; Correia, María Isabel Toulson Davisson; Júnior, Hilario Antonio de Castro; Speschit, Wagner; Silveira, Raphael de Oliveira Pessoa; Nunes, Cristiana Buzelin; Abrantes, Marcelo Militão

doi:10.1590/s0100-69912009000200011

Cited by 1 publication

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“…Previous studies have shown that glycine contributes to the inhibition of TNF‐α and IL‐1β (Hartog et al, ; Figueiredo et al, ). These inflammatory molecules are involved in the induction of apoptosis (Kim et al, ) and the activation of metalloproteinases involved in the excessive degradation of matrix components (Tsuzaki et al, ).…”

Section: Discussionmentioning

confidence: 96%

“…Glycine is an amino acid with a simple molecular structure, and it displays important biological activities by acting as a modulator of the systemic inflammatory cascade, improving the microcirculation and assisting in the inhibition of TNF‐α and IL‐1β (Hartog et al, ; Figueiredo et al, ). Many studies have proposed glycine as a useful treatment for many types of inflammatory processes (Hartog et al, ; Weeler et al, ; Carmans et al, ; Stoffels et al, ).…”

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Glycine Improves Biochemical and Biomechanical Properties Following Inflammation of the Achilles Tendon

Vieira

Oliveira

Guerra

et al. 2014

The Anatomical Record

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Tendinopathy of the Achilles tendon is a clinical problem that motivates the scientific community to search for treatments that assist in restoring its functional properties. Glycine has broad biological effects, acting as a modulator of the inflammatory cascade, and is the predominant amino acid in collagen. A 5% glycine diet provided beneficial effects against toxicity and inflammation since glycine may restructure the collagen molecules faster due to its broad anti-inflammatory effects. The purpose was analyze the effects of a 5% glycine diet in rats as a treatment for the inflammatory process. The experimental groups were as follows: C (control group), G1 and G3 (inflammatory group), and G2 and G4 (glycine 1 inflammatory group). G1 and G2 were euthanized 8 days following injury, and G3 and G4 were euthanized 22 days following injury. The concentrations of hydroxyproline, noncollagenous proteins, and glycosaminoglycans, as well as the activity of MMP-2 and -9 were analyzed. Biomechanical and morphological tests were employed. Higher concentrations of hydroxyproline and glycosaminoglycans were found in G4 and an increased activity of MMP-2 was found in G2. Higher birefringence was noted in group G2. The biomechanical results indicated that the tendon was more resistant to loading to rupture upon treatment with a glycine diet in group G4. Glycine induced the synthesis of important components of the tendon. A rapid remodeling was noted when compared with the inflamed-only groups. These data suggest that glycine may be a beneficial supplement for individuals with inflammation of the Achilles tendon. Anat Rec, 298:538-545, 2015. V C 2014 Wiley Periodicals, Inc.Key words: tendinopathy; achilles tendon; glycine; inflammatory process; extracellular matrixTendon injuries often occur in tendons that are exposed to high mechanical forces and that undergo more extensive matrix remodeling, such as the Achilles, supraspinatus and patellar tendons (Benjamin et al., 2008;Wang et al., 2012). The biomechanical properties of tendons depend on the structural arrangement of the collagen fibrils, fiber diameter, and the molecular aggregation of the collagen. The fibrils aggregate into collagen fibers that are responsible for the resistance of the tendon, and the efficiency of this mechanism depends on the parallel arrangement of these fibers in the direction of the tension forces (James et al.,

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Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

Glycine Improves Biochemical and Biomechanical Properties Following Inflammation of the Achilles Tendon

Vieira

Oliveira

Guerra

et al. 2014

The Anatomical Record

View full text Add to dashboard Cite

show abstract

Efeito da suplementação nutricional com glicina e glutamina, por via oral, na cicatrização colônica em coelhos

Abstract: Oral supplementation with glycine, in the pre and post-operative periods increases the tensile strength of colonic anastomoses after partial colectomy in rabbits. The oral supplementation with glutamine did not present detectable effect on the colonic anastomoses in rabbits.

Cited by 1 publication

References 18 publications

Glycine Improves Biochemical and Biomechanical Properties Following Inflammation of the Achilles Tendon

Glycine Improves Biochemical and Biomechanical Properties Following Inflammation of the Achilles Tendon

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