Titrimetric assay of lisinopril in aqueous and non-aqueous media

Basavaiah, K.; Tharpa, Kalsang; Vinay, K. B.

doi:10.1590/s0100-46702010000200001

Cited by 7 publications

(3 citation statements)

References 9 publications

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“…The method consisted of the titration of the aqueous solution of the tablet containing lisinopril with 0.1 M NaOH potentiometrically and requires fairly large quantities of LNP for each titration. [19] A ultraviolet-visible (UV-Vis) spectroscopy is an analytical technique that measures the amount of discrete wavelengths of UV or visible light that are absorbed by or transmitted through a sample in comparison to a reference or blank sample. [15] Determination of the lisinopril by UV-Vis spectroscopy is a simple, easy, fast, cheap method.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2022

IJPSCR

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A simple, accurate, fast, and cheap titrimetric assay method and ultraviolet-visible (UV-Vis) spectrophotometric method have been developed for the assay of lisinopril in pharmaceutical pure and tablet dosage form. The method developed in titrimetric method is a color-based indicator method. The assay of lisinopril by UV is based on its absorbance in the UV range. Lisinopril is a long-acting angiotensin-converting enzyme inhibitor. It is used as a first-line drug to manage hypertension, congestive heart failure, and acute myocardial infarction. The titrimetric method is a type of neutralization reaction using methanol as solvent and titrating it against 0.1 N NaOH and 3-4 drops of phenolphthalein as indicator and the appearance of permanent pink color is taken as the endpoint. The average volume of 0.1 N NaOH consumed to neutralize the content in flask was noted and the percent purity of the drug in the tablet formulation was calculated. The analytical methods reported for the determination of lisinopril in tablets are generally based on spectrophotometric measurements. A UV-Vis spectroscopy is an analytical technique that measures the amount of discrete wavelengths of UV or visible light that are absorbed by or transmitted through a sample in comparison to a reference or blank sample. The assay of lisinopril was performed by ethanol and water as diluents and the absorption maxima were at 208 nm. The concentration of the sample was determined by standard calibration curve method. The titrimetric method and UV-Vis spectroscopic method developed are easy, rapid, and simple and can be used as a routine quality control test for both the pure drug and in tablet formulation.

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Section: Introductionmentioning

confidence: 99%

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2022

IJPSCR

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“…The literature reveals various analytical methods were described for the determination of LNP such as titrimetric [5,6], Spectrophotometric [7][8][9][10][11][12][13][14][15], spectrofluorometric [16][17][18][19][20], chromatographic [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38], derivative UV-spectrophotometric, [39][40] polarography [41][42], radioimmunoassay [43] and fluoroimmunoassay [44].…”

Section: Introductionmentioning

confidence: 99%

Determination of Lisinopril in Pure and Tablet form by Using 2-Hydroxynaphthaldehyde as Derivatizing Reagent

zounr

2021

Pak J Anal Environ Chem

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An easy, sensitive and accurate spectrophotometric method has been developed for the determination of Lisinopril (LNP) in pure and tablet formulations based on derivatization reaction with 2-hydroxynaphthaldehyde (2HNA). The derivatization reaction was carried out in methanol solvent at pH-5.5 at 95±2C for 15 min. The linear calibration curve was obtained that obeyed the Beer’s law within the concentration range 5-50 μgmL-1 of LNP at 433 nm with a coefficient of determination R²=0.996. The recovery was in the range from 98.25-101.82 with molar absorptivity of drug 9×103 mole-1cm-1. The method was accurate and precise (intra-day variation 0.05-0.97% and inter-day 0.07-1.6%), with limit of detection (LOD) and limit of quantification (LOQ) 0.264 μgmL-1 and 0.8 μgmL-1, respectively. No interferences from the excipients were detected. The method was applied for the rapid analysis of LNP in pharmaceutical products.

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“…Various analytical procedures were found in the literature for the determination of LNP using titrimetric (Basavaiah et al, 2010), visible spectrophotometric (Rahman et al, 2007;El-Yazbi et al, 1999;Rahman et al, 2005;El-Gindy et al, 2001;Paraskevas et al, 2002;Nafisur et al, 2005;Asad et al, 2005;Rajasekaran, and Udayavani, 2001;Basavaiah et al, 2009;Razak et al, 2003), derivative UV absorption spectrophotometric (El-Yazbi et al, 1999;Bonazzi et al, 1997a, b;Durisehvar and Hulya, 1999;Beata, 2005;Erk, 1998;Prasad et al, 1999;Jain and Agrawal, 2000;Mashru and Parikh, 2000), high-performance liquid chromatographic (HPLC) (The US Pharmacopoeia, 2000;Ivanoic et al, 2007;Nevin and Murat, 1999;Sane et al 1992;Bonazzi et al, 1997a, b;El-Gindy et al, 2001;Christopher et al, 2004), highperformance thin layer chromatographic (HPTLC) (Pandya et al, 2017), gas chromatographic (Avadhanulu and Pantulu, 1993), capillary electrophoretic (Qin et al, 1993;Gotti et al 2000), spectrofluorimetric (El-Gindy et al, 2001;Esra et al, 2003;Zacharis et al 2004), and polarographic (Razak et al 2003;El-Enany, Belal, and Al-Ghannam, 2003;…”

Section: Introductionmentioning

confidence: 99%

Development of membrane electrodes for selective determination of lisinopril in pharmaceuticals

Rajendraprasad

Basavaiah

2019

J Anal Sci Technol

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Background: Lisinopril (LNP) is an angiotensin-converting enzyme inhibitor used as anti-hypertensive, cardiovascular, in anti-prophylactic and anti-diabetic nephropathy drug. Development of two new, simple, low cost, and selective membrane-based ion-selective electrodes has been proposed for the determination of LNP in pharmaceuticals. Methods: The electrodes are based on poly(vinyl)chloride membrane doped with LNP-phosphotungstic acid (LNP-PTA) and LNP-phosphomolybdic acid (LNP-PMA) ion-pairs as molecular recognition materials. Results: The developed LNP-PTA and LNP-PMA electrodes are applicable for the determination of LNP over the linear range of 5 × 10 −5 -2.4 × 10 −3 mol l −1 . The working pH ranges to measure potentials were 2.5 to 6.4 and 2.3 to 6.0 for LNP-PTA and LNP-PMA ISEs, respectively. The electrodes displayed the rapid Nernstian responses as revealed by the values of slopes 55.06 and 52.39 mV/decade, with limit of detection (LOD) values of 1.2 × 10 −5 and 1.18 × 10 −5 mol l −1 for LNP-PTA and LNP-PMA electrodes, respectively. The limits of quantitation (LOQ) values have also been calculated for both the electrodes. The developed electrodes have potential stability for up to 1 month and emerged as highly selective for the determination of LNP over other spiked ions and compounds. Conclusions: The proposed electrodes have been validated and found that they are suitable for the determination of LNP in pharmaceuticals in pure form and in dosage forms. The results obtained in the analysis of LNP using proposed electrodes have been compared statistically with reference method's results to assess the accuracy and precision. Robustness and ruggedness of the developed electrodes have also been checked and found satisfactory. The recovery studies have been performed by standard addition procedure to assess the role of excipients in tablets containing LNP and the results obtained are satisfactory.

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Titrimetric assay of lisinopril in aqueous and non-aqueous media

Cited by 7 publications

References 9 publications

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Determination of Lisinopril in Pure and Tablet form by Using 2-Hydroxynaphthaldehyde as Derivatizing Reagent

Development of membrane electrodes for selective determination of lisinopril in pharmaceuticals

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