Síntese e caracterização de complexos de platina (II) contendo iodeto e derivados do furano como ligantes

Abstract

Alguns compostos de platina (II), como por exemplo, cisplatina, carboplatina e oxaloplatina, têm sido utilizados como agentes quimioterápicos no tratamento de vários tipos de câncer. Contudo, na tentativa de reduzir a toxicidade e ampliar o espectro de atividade da cisplatina e de seus análogos, milhares de complexos têm sido preparados variando a natureza dos ligantes. Este trabalho descreve a síntese e caracterização de novos complexos de platina, tendo iodeto e derivados do furano como ligantes. Os complexos foram caracterizados por RMN, IV e análise elementar.

Antifungal activities of thiosemicarbazones and semicarbazones against mycotoxigenic fungi

“…The thiosemicarbazones (1-8) were synthesized from appropriate aldehydes and thiosemicarbazide under acid catalysis as previously described (Oliveira et al, 2008), and the semicarbazones (9-17) from aldehydes, semicarbazide hydrochloride and sodium acetate in ethanol as a solvent (Guerra et al, 2006) (Figure 1). The thiosemicarbazones were obtained with 60-95% yield and the semicarbazones with 45-95% yield.…”

“…Thiosemicarbazones were synthesized using the appropriate aldehydes and thiosemicarbazide, with drops of concentrated sulfuric and ethanol as a solvent, as previously described in the literature (Oliveira et al, 2008). Semicarbazones were prepared using aldehydes and semicarbazide hydrochloride in the presence of sodium acetate, with ethanol as a solvent (Guerra et al, 2006). All products were characterized by infrared, mass, 1 H and 13 C NMR spectroscopies.…”

“…To determine the stoichiometry of the thiosemicarbazone-Fe 2+ complex, the L-M Mollard Method was used, with Fe 2+ ranging from 25 to 225mM and thiosemicarbazones ranging from 225 to 25 mM, according to equation 3 (Guerra et al, 2006;Farias, 2009).…”