Síntese da Epoxone a partir de D-frutose: um experimento didático em laboratório de Química Orgânica com foco nos princípios da Química Verde

Synthesis of substituted N-phenylmaleimides and use in a Diels–Alder reaction: a green multi-step synthesis for an undergraduate organic chemistry laboratory

“…Since the publication of Green Chemistry: Theory and Practice by Anastas and Warner 20 years ago (44), there has been a multitude of experiments published to illustrate green chemistry through the redesign of organic reactions (45,46). However, there have been many fewer multi-step synthesis experiments published that incorporate green chemistry principles into the synthetic design (47)(48)(49)(50)(51)(52)(53)(54)(55). Three of these green syntheses are accomplished without isolation and purification of the intermediate products (49,53,55).…”

“…Three of these green syntheses are accomplished without isolation and purification of the intermediate products (49,53,55). Several of the experiments are designed to introduce students to multistep synthesis using commonly discussed sophomore organic chemistry reactions (48,51,52,54). The other experiments accomplish this goal while exposing the students to the synthesis of a biologically and/or commercially important compound (47,49,50,53,55).…”