Thermodynamic study of the solubility of sodium naproxen in some ethanol + water mixtures

Abstract

Recebido em 10/3/10; aceito em 16/6/10; publicado na web em 24/9/10 By using the van't Hoff and Gibbs equations the apparent thermodynamic functions Gibbs energy, enthalpy, and entropy of solution for sodium naproxen in ethanol + water cosolvent mixtures, were evaluated from solubility data determined at temperatures from (278.15 to 308.15) K. The drug solubility was greatest in neat water and lowest in neat ethanol at all the temperatures studied. By means of non-linear enthalpy-entropy compensation analysis, it follows that the dissolution process of this drug in ethanol-rich mixtures is entropy-driven, whereas, in water-rich mixtures the process is enthalpy-driven.

Hydroxy double salts loaded with bioactive ions: Synthesis, intercalation mechanisms, and functional performance

“…The Nap release profile from CoZn-Nap is given in Figure 10(b); the full drug loading was released within 5 h. Nap is thus released more rapidly than Dic from the CoZn system, which could be explained by the higher solubility of the former. 55,56 The release profiles seen here are more sustained than those previously observed. LDHs in general have been shown to release their drug cargo more quickly than HDSs and here Nap release proceeds more slowly than has been reported from both LDHs and HDSs, where complete release in less than 100 min was seen.…”

Solubility and saturation apparent specific volume of some sodium sulfonamides in propylene glycol + water mixtures at 298.15 K

“…This apparently contradictory behavior is a consequence of the definitions of the respective scales [17]. Similar behaviors have been reported in the literature for other salt form of drugs in ethanol (1) + water (2) mixtures [18][19][20][21][22]. From an empirical point of view the solubility of these salt form of drugs in the mixtures studied could be considered as varying from freely soluble to soluble, i.e.…”

IUPAC-NIST Solubility Data Series. 102. Solubility of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Neat Organic Solvents and Organic Solvent Mixtures

“…There have been two experimental studies 196,197 reporting the solubility of sodium naproxen in organic solvents. Delgado et al 196 determined the solubility of sodium naproxen in binary aqueous-ethanol solvent mixtures over the entire composition range, including the two pure solvents.…”

“…There have been two experimental studies 196,197 reporting the solubility of sodium naproxen in organic solvents. Delgado et al 196 determined the solubility of sodium naproxen in binary aqueous-ethanol solvent mixtures over the entire composition range, including the two pure solvents. Measurements were performed in 5 K increments between 278 and 308 K. The internal consistency of the Delgado et al dataset was assessed by curve-fitting the measured mole-fraction solubility data to the Modified Apelblat model [Eq.…”