Terbinafine: optimization of a LC method for quantitative analysis in pharmaceutical formulations and its application for a tablet dissolution test

Tagliari, Monika Piazzon; Kuminek, Gislaine; Borgmann, S. H. M.; Bertol, Charise Dallazem; Cardoso, Simone Gonçalves; Stulzer, Hellen Karine

doi:10.1590/s0100-40422010000800029

Cited by 17 publications

(13 citation statements)

References 12 publications

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“…The obtained extracts (300 mL) were evaporated to dryness using a rotary vacuum evaporator at 22 °C ± 2 °C, and then the dried extracts were dissolved in methanol and filtered through a 0.2-μm filter. The concentration of terbinafine was determined using RP-HPLC according to the procedure developed by Tagliari (2010). Briefly, the separation was carried out on Hitachi HPLC apparatus (Merck, Tokyo, Japan) equipped with an L-7100 pump, Purospher® RP-C 18 (200 mm × 4 mm , 5 μm) column (Merck, Tokyo, Japan), using methanol-water (95:5, v/v) as a mobile phase, and a flow rate of 1 mL min −1 with UV detection at λ = 254 nm.…”

Section: Rp-hplc Analysismentioning

confidence: 99%

Feasibility of the use of Lentinula edodes mycelium in terbinafine remediation

et al. 2020

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A detailed understanding of the fate of xenobiotics introduced into the environment and the mechanisms involved in their biotransformation, biodegradation, and biosorption is essential to improve the efficiency of remediation techniques. Mycoremediation is a form of bioremediation technique that has become increasingly popular in recent years as fungi are known to produce various effective extracellular enzymes that have the potential to neutralize a wide variety of xenobiotics released into the environment. Hence, mycoremediation appears to be a promising technique for the removal of a wide array of toxins and pharmaceutical residues from a damaged environment and wastewater. This study primarily aimed to investigate whether white-rot fungus (Lentinula edodes) can be utilized for the bioremediation of common antifungal agent terbinafine, which is mainly available in the market as powder or cream. The cultures of L. edodes were cultivated in the medium containing terbinafine powder or terbinafine 1% cream, each at a final concentration of 0.1 mg mL −1. The addition of terbinafine in powder form have a negative effect on biomass growth (p < 0.05). The total amount of terbinafine in the dry weight of mycelium after culture was estimated to be 7.63 ± 0.45 mg and 12.52 ± 2.46 mg for powder and cream samples, respectively. In addition, there were no traces of terbinafine in any of the samples of medium used for culturing L. edodes after the experimental duration period. The biodegradation products of terbinafine were identified for the first time using UPLC/MS/MS. The biodegradation of terbinafine resulted in the loss of 1-naphthylmethanol, which occurred via oxidative deamination, N-demethylation, or tert-butyl group hydroxylation. The results of the study demonstrate that L. edodes mycelium can be effectively used for the remediation of terbinafine.

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Section: Rp-hplc Analysismentioning

confidence: 99%

Feasibility of the use of Lentinula edodes mycelium in terbinafine remediation

et al. 2020

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“…Different HPLC methods were reported for the assay of TRH either in dosage forms as cream [12][13][14], Tablets [15][16][17] and liniment [18], or in biological fluids [19][20][21][22][23][24][25]. Various spectrophotometric methods have also been used for the analysis of TRH (23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

Micellar Liquid Chromatography Coupled with Fluorometric Detection for the Determination of Terbinafine in Dosage Forms and Plasma

Belal¹,

Mk²,

Mi³

et al. 2016

J Chromatogr Sep Tech

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“…Moreover, terbinafine has been determined in biological fluids by high‐performance liquid chromatography (HPLC) technique and microbiological bioassay . HPLC methods have also been used for determining the drug in tablet and cream forms . Among these methods, HPLC has been considered as the specific method due to the performance and strong separation ability.…”

Section: Introductionmentioning

confidence: 99%

Extracting trace amount of terbinafine hydrochloride in biological fluids and wastewater samples using solid‐phase‐extraction based on magnetic nanoparticles followed by HPLC‐UV analysis

Abbasi

Faraji²,

Bahmaie

2014

Asia-Pacific J Chem Eng

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In this paper, the application of sodium dodecylsulfate-coated Fe 3 O 4 nanoparticles as an adsorbent was evaluated for the extraction and preconcentration of trace amounts of terbinafine hydrochloride in biological fluids before its determination by high-performance liquid chromatography with ultraviolet detection. Effects of various parameters on the extraction efficiency such as pH of solution, amount of sodium dodecylsulfate surfactant, extraction time, and desorption conditions were studied and optimized. Under the optimal conditions, the calibration curve was linear in the range of 2.5 to 500 μg L À1with the correlation coefficient of 0.9998. Moreover, the calibration graphs were linear in the range of 5 to 500 μg L À1 (seven standards)for both urine and plasma samples and the limits of detection were found to be 0.3, 0.7, and 1.5 μg L À1in aqueous, urine, and plasma samples, respectively. Also, the percent of relative standard deviation (RSD%) based on three replicate determinations was in the range of 0.9% to 6.8%. Finally, the proposed method was successfully applied for the extraction of terbinafine from real samples, and satisfactory results were obtained.

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Terbinafine: optimization of a LC method for quantitative analysis in pharmaceutical formulations and its application for a tablet dissolution test

Cited by 17 publications

References 12 publications

Feasibility of the use of Lentinula edodes mycelium in terbinafine remediation

Feasibility of the use of Lentinula edodes mycelium in terbinafine remediation

Micellar Liquid Chromatography Coupled with Fluorometric Detection for the Determination of Terbinafine in Dosage Forms and Plasma

Extracting trace amount of terbinafine hydrochloride in biological fluids and wastewater samples using solid‐phase‐extraction based on magnetic nanoparticles followed by HPLC‐UV analysis

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