Blainvillea rhomboidea: constituintes químicos e atividade citotóxica

Abstract

Recebido em 13/9/09; aceito em 21/1/10; publicado na web em 3/5/10Blainvillea rhomboidea: CHEMICAL CONSTITUENTS AND CYTOTOXIC ACTIVITY. The phytochemical investigation of the ethanol extract from the aerial parts of Blainvillea rhomboidea (Asteraceae) resulted in the isolation and characterization of 8β-tigloyloxy-grazielia acid, together with the flavonoids derrone, acacetin, luteolin and luteolin 7-methyl ether, and p-(1-methylethan-1-ol)-phenol. The structures of all compounds were determined by spectroscopic methods ( 1 H and 13 C NMR and HREIMS) and comparison with published spectral data. The flavonoids luteolin and 7-O-metyl-luteolin, isolated from the active dichloromethane fraction, showed moderate cytotoxic activity.