Chemical constituents of the wood from Zanthoxylum quinduense Tul. (Rutaceae)

Patiño-Ladino, Oscar J.; Suárez, Luís Enríque Cuca

doi:10.1590/s0100-40422010000500002

Cited by 20 publications

(4 citation statements)

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“…As such, drugs like chloroquine, artemisinin derivatives and morphine have been derived from different plant sources [ 9 ]. Zanthoxyllum contains about 549 species distributed worldwide; making it the largest genus in Rutaceae [ 10 ] Zanthoxyllum leprieurii, a plant species belonging to the same family, is traditionally used in the treatment of HIV/AIDS, malaria, urinary infections, rheumatic pain and is used as an antiseptic in Africa [ 11 , 12 ]. In addition, it is used by communities in Uganda for management of TB and cough related infections [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Potential of Zanthoxylum leprieurii as a source of active compounds against drug resistant Mycobacterium tuberculosis

Bunalema

Fotso

Waako

et al. 2017

BMC Complement Altern Med

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BackgroundTuberculosis (TB) is still a global health problem mainly due to development of resistance and co-infection with the Human immune Virus (HIV). Treatment of multi and extensively drug resistant TB requires use of second line drugs which are less efficacious, expensive and very toxic. This has necessitated a need to search for new treatment regimens especially from medicinal plants. Zanthoxylum leprieurii, a plant species from Rutaceae is used locally in the treatment of tuberculosis in Uganda. The aim of the study was to isolate, identify and characterize bio active compounds from Z. leprieurii stem bark with antimycobacterial activity.MethodsCrude extracts, fractions and compounds from air dried stem bark of Z. leprieurii were tested against pan sensitive (H37rv), isoniazid resistant (TMC 301) and rifampicin resistant (TMC 331) strains of M. tuberculosis using micro plate alamar blue assay. Isolation of active compounds was done by using column chromatography and thin layer chromatography. They were analysed using nuclear magnetic resonance spectroscopy and mass spectroscopy.ResultsThe methanol extract had minimum inhibitory concentrations (MIC) of 47.5, 75.3 and 125.0 μg/ml on the pan sensitive strain, rifampicin resistant and isozianid resistant strains of M. tuberculosis respectively. The chloroform extract had MIC values of 260 μg/ml agnaist the pan sensitive strain and 156 μg/ml on the rifampicin resistant strain. Of the sixteen fractions from the methanol extract, fraction Za4 (MIC = 6.3 μg/mL, 23.0 μg/mL, 11.7 μg/mL) and Za6 (MIC = 11.7 μg/mL 31.2 μg/ml, 31.2 μg/ml) were the most active. Three acridone alkaloids; hydroxy-1, 3-dimethoxy-10-methyl-9-acridone (1), 1-hydroxy-3-methoxy-10-methyl-9-acridone (2) and 3-hydroxy-1, 5, 6-trimethoxy-9-acridone (3) were isolated from Za4 and Za6. The MIC of compound 3 was found to be 5.1 μg/ml, 4.5 μg/ml and 3.9 μg/ml on H37rv, TMC 331 and TMC 301 while that of 1 was found to be 1.5 μg/ml, 8.3 μg/ml and 3.5 μg/ml respectively.ConclusionThe results of this study suggest that Z. leprieurii is active on resistant strains of M. tuberculosis and could be a potential source of new leads against resistant tuberculosis. It also verifies the local use of the plant in treatment of tuberculosis.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-017-1602-x) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Potential of Zanthoxylum leprieurii as a source of active compounds against drug resistant Mycobacterium tuberculosis

Bunalema

Fotso

Waako

et al. 2017

BMC Complement Altern Med

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“…Estudio fitoquímico del extracto etanólico de raíz de Zanthoxylum caribaeum (Rutaceae) y obtención de metabolitos secundarios con posible actividad neuroprotectora aplicable en el tratamiento de la enfermedad de Alzheimer Cabe resaltar que las partes de la planta que más se utilizan dentro de la medicina tradicional son las hojas, tallo y raíces, por lo que supone que en estas se encuentran concentrados el mayor número de metabolitos, siendo las formas de preparación más común las infusiones y las decocciones (Dieguez, Rivas, Prieto, Garrido, & Molina, 2004) En la Tabla 1-1, se pueden observar algunas referencias de los usos tradicionales de algunas especies del género Zanthoxylum a nivel mundial. (Patiño, 2010).…”

Section: Usos Etnobotánicos Del Genero Zanthoxylumunclassified

“…Los alcaloides representan la familia química más relevante, presente en casi todas las especies estudiadas del género Zanthoxylum; cerca del 90% de los reportes encontrado en la literatura confirman la presencia de este tipo de metabolitos en diversas partes de la planta (Dieguez et al 2004), y en general de los tipos isoquinolinícos (benzofenantridínicos, bencilisoquinolínicos, aporfínicos, protoberberínicos y berberínicos) y quinolínicos (Patiño, 2010).…”

Section: Usos Etnobotánicos Del Genero Zanthoxylumunclassified

“…Los alcaloides benzofenantridínicos han sido los más estudiados debido a sus propiedades antitumorales, atioxidantes, antimalaricas, antibacterianas, antimicrobinas y antifungicas entre otras (Patiño, 2010) (Plazas et al, 2018). La estructura general de los alcaloides benzofenantridínicos se muestra en la Figura 1-5, junto con las variaciones características de sus principales representantes.…”

Section: Usos Etnobotánicos Del Genero Zanthoxylumunclassified

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Chemical Composition, Antimicrobial, Repellent and Antioxidant Activity of Essential Oil ofZanthoxylum caribaeumLam

Souza

Toledo

Walerius

et al. 2019

Journal of Essential Oil Bearing Plants

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Thus, the bioguided purification led to the isolation and characterization of the following compounds: 6,8-dimethoxy-2-H-1-quinolin-2-one, 3-((1-methylciclopentil) amino) quinolin-2(1H)-one, 104-ozaxol [3,2-a] quinoline and Anthranilic acid and the evaluation of its possible neuroprotective activity, based on the results of antioxidant and anticholinergic activity, showed that the compounds individually present medium to low antioxidant activities and that the anticholinergic activity is lost as the putification progresses, the fractions being more active than the pure compounds.

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Extracellular biosynthesis of anti‐Candida silver ‎nanoparticles using Monascus purpureus

El-Baz

El-Batal

Abomosalam

et al. 2015

J. Basic Microbiol.

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An eco-friendly process for the silver nanoparticles (Ag-NPs) biosynthesis was investigated using the fungus Monascus purpureus as a safe and commercially used microorganism. M. purpureus growth filtrate was used for the reduction of the aqueous silver nitrate into Ag-NPs with almost 100% size range of 1-7 nm, which was considered as one of the smallest microbial biosynthesized Ag-NPs. The biosynthesized Ag-NPs were structurally characterized using UV, FTIR, DLS, TEM, and XRD. The biosynthesized Ag-NPs were stable after 3 months with no alteration in shape or size. M. purpureus showed no nitrate reductase activity, whereas its pigments reducing power was decreased after nanoparticles formation indicating its role in the Ag-NPs biosynthesis. The synthesized Ag-NPs exhibited strong antimicrobial activity against different bacteria and yeasts species. The anti-Candida activity of M. purpureus culture filtrate was enhanced in the presence of Ag-NPs; the maximum increase in microbial inhibition was observed against Candida albicans with 1.73 increased folds of inhibition zones, followed by their activity against C. tropicalis and C. glabrata with 0.919- and 0.694-folds of increase, respectively. The obtained results suggest that the biosynthesized Ag-NPs offers a promising cost-effective, eco-friendly, and an alternative way to the conventional method of synthesis that could have wide applications in medicine.

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Chemical constituents of the wood from Zanthoxylum quinduense Tul. (Rutaceae)

Cited by 20 publications

References 12 publications

Potential of Zanthoxylum leprieurii as a source of active compounds against drug resistant Mycobacterium tuberculosis

Potential of Zanthoxylum leprieurii as a source of active compounds against drug resistant Mycobacterium tuberculosis

Chemical Composition, Antimicrobial, Repellent and Antioxidant Activity of Essential Oil ofZanthoxylum caribaeumLam

Extracellular biosynthesis of anti‐Candida silver ‎nanoparticles using Monascus purpureus

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