Caldensinic acid, a benzoic acid derivative and others compounds from Piper carniconnectivum

Abstract

Recebido em 20/4/09; aceito em 8/12/09; publicado na web em 24/3/10 A benzoic acid derivative -caldensinic acid; E-phytyl hexadecanoate; β-sitosterol and stigmasterol mixture and phaeophytin a were isolated from the aerial parts of Piper carniconnectivum. The structures of these compounds were established unambiguously by IR, MS, 1D and 2D NMR analysis.

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“…The compound 1 was characterized as caldensinic acid with base on its 1 H NMR spectrum. Its 1 H NMR spectrum indicated the presence of aromatic hydrogen at δ 7.8, three signals at δ 6.8, 5.3 and 5.1, associated to four olefin hydrogen, one signal of benzylic methylene at δ 3.4, a signal set between 1.5 and 1.8 ppm, attributed to methyl groups linked to sp2 carbons, a broad group of signals between 2.0 and 2.4 ppm, assigned to twelve methylene hydrogen according to the literature [12][13]. The caldensinic acid has been previously reported as major compound of P. caldense leaf, and showed antifungal activity against the phytopathogenic fungi Cladosporium cladosporioides and C. sphaerospermum [12].…”