Metabólitos secundários de origem vegetal: uma fonte potencial de fármacos antitrombóticos

Chaves, Douglas Siqueira de Almeida; Costa, Sônia Soares; Almeida, Ana Paula de; Frattani, Flávia Serra; Assafim, Mariane; Zingali, Russolina B.

doi:10.1590/s0100-40422010000100030

Cited by 24 publications

(14 citation statements)

References 51 publications

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“…To complement these findings, normal smears and those with addition of plant extracts were done (Figure 1). The use of antithrombotic plants could be an alternative to reduce the side effects from pharmaceutical products commonly used in thrombotic-related diseases (Chaves et al, 2010). At first an alcoholic extract was prepared which was more effective solvent for extracting secondary metabolites than aqueous extracts (Chandrasekaran and Venkatesalu, 2004).…”

Section: Resultsmentioning

confidence: 99%

Preliminary Studies on Anticoagulation and Antiplatelet Activities of Plinia cauliflora (Mart.) Kausel Leaves Extract

Tanelli¹,

Belardo²,

Peiró³

et al. 2017

J App Pharma Sci

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The objective of this study was to evaluate the effect of aqueous extracts of Plinia cauliflora (DC.) Kausel leaves in different concentrations (0.5 to 10.0% (w/v)), on the hemostasis through changes in platelet aggregation and blood coagulation. Has been assessed by phytochemical screening (total phenols; tannins; flavonoids; alkaloids and saponins) of Plinia cauliflora (DC.) Kausel leaves using standard methodologies. The human blood by discard sample was used. The coagulation assay was carried out with 'thromboplastin hemostasis' for prothrombin time (PT) and activated partial thromboplastin time (aPTT) commercial kit, where platelets were determined by complete blood count (CBC) analyzer. The phytochemical screening showed the presence of total phenols; tannins and flavonoids. In assessing the anticoagulant activity, the aqueous extracts of P. cauliflora (DC.) Kausel leaves in different concentrations (2.0%; 2.5%; 5.0% and 10.0% (w/v) didn't show any coagulation and could not be measured on the analyzer. Hemogram (CBC) of the sample results showed a significant reduction in platelet concentration, especially in aqueous extracts 2.5%, while the other parameters did not seem to be significantly affected. Based on these preliminary results, it can be suggested that the aqueous extract of this species has anticoagulant and antiplatelet activities.

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Section: Resultsmentioning

confidence: 99%

Preliminary Studies on Anticoagulation and Antiplatelet Activities of Plinia cauliflora (Mart.) Kausel Leaves Extract

Tanelli¹,

Belardo²,

Peiró³

et al. 2017

J App Pharma Sci

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“…Quantitative evaluation of the antioxidant activity of the crude extract and fractions was performed according to the methodology described by Chaves et al (2010). The radical consumption was monitored by the decrease of their absorbance Ultraviolet-visible spectroscopy (UV-VIS) spectrophotometer (UV BEL PHOTONICS 1105) at 515 nm, using glass cuvettes with 1 cm optical path.…”

Section: 1-diphenyl-2-picryl Hidrazyl (Dpph) Methodsmentioning

confidence: 99%

Myracrondruon urundeuva Allemo: Chemical composition, antioxidant activity, antimicrobial activity and inotropic effect

Santos¹,

Lima²,

Andrade³

et al. 2017

Afr. J. Biotechnol.

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Caatinga biome features species with high therapeutic potential such as Aroeira do Sertão (Myracrodruon urundeuva Allemão) which has long history in folk medicine. This study aimed to chemically characterize the secondary metabolites of hydroethanolic extract and hexane, chloroform, acetate, hydroethanolic fractions from Myracrodruon urundeuva (Allemão) possibly responsible antioxidant and antimicrobial activity, besides to evaluate the inotropic effect of crude extract in the left atrium of Cavia porcellus. Phytochemical composition was evaluated by spectrophotometry and highperformance liquid chromatography (HPLC). Antioxidant activity was assessed by 2,2-diphenyl-1-picryl hidrazyl (DPPH•) scavenging and reactive substances to thiobarbituric acid methods. Inotropic effect was evaluated using the isolated organ model. Data were expressed as mean ± SEM and differences determined by ANOVA followed by Tukey test. Phytochemical screening and the HPLC confirmed the presence of flavonoids, terpenes, tannins. Acetate and Hydroethanolic extract showed inhibition of DPPH values of 81.56 and 93.28% respectively. On the other hand, TBARS reduced in extract were 64.13% in a concentration of 150 µg/mL. Hydroethanolic extract and acetate fraction with concentrations of 50 and 100 mg/mL showed inhibition zones between 11.00 and 20.50 mm suggesting antimicrobial activity against Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae bacteria and Candida albicans. The isolated atrium model demonstrated that the extract acts non-competitively antagonizing muscle calcium currents, decreasing the force of contraction by about 60%. Flavonoids, terpenes and tannins are responsible for M. urundeuva (Allemão) biological effects.

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“…Em condições normais, a enzima EPSP catalisa, na planta, a reação que envolve a transferência do enolpiruvil do fosfoenolpiruvato (PEP) para o chiquimato-3-fosfato (S3P), formando 5-enolpiruvil-chiquimato-3-fosfato (EPSP) e fosfato inorgânico, Pi (Figura 4) (Coutinho & Mazo, 2005).…”

Section: Biossíntese Da Cumarinaunclassified

“…A varfarina (Figura 6, 12) cuja estrutura química resulta de uma modificação da cumarina (Figura 6, 13), é um anticoagulante oral que atua como inibidor da vitamina K, um cofator essencial para a síntese de fatores da coagulação II, VII, IX e X (Chaves et al, 2010). Outras moléculas com o esqueleto químico das cumarinas, como acenocumarol (Figura 6,14), femprocumona (Figura 6,15) e dicumarol (Figura 6,16), também apresentam atividade anticoagulante (Chaves et al, 2010).…”

Section: Interações Medicamentosas E Toxicidadeunclassified

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Farmacobotânica, fitoquímica e farmacologia do Guaco: revisão considerando Mikania glomerata Sprengel e Mikania laevigata Schulyz Bip. ex Baker

Czelusniak

Brocco

Pereira

et al. 2012

Rev. bras. plantas med.

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RESUMO:As plantas medicinais vêm sendo cada vez mais utilizadas devido às suas propriedades preventivas, paleativas e curativas, além de ser uma terapia alternativa que traz inúmeros benefícios aos usuários. As espécies Mikania glomerata e M. laevigata pertencem à família Asteraceae e são popularmente conhecidas como guaco sendo utilizadas no tratamento de enfermidades do trato respiratório. Além disso, as duas espécies são frequentemente confundidas ou citadas na literatura de forma errada. O presente trabalho teve por objetivo realizar uma revisão bibliográfica sobre a farmacologia, farmacobotânica e fitoquímica dos metabólitos secundários de Guaco, tendo destaque a cumarina, a biossíntese e as ações biológicas. As ações broncodilatadora, expectorante, anti-inflamatória e antialérgica, além de interações com alguns antibióticos e anticoagulantes, também foram descritas neste estudo. Palavras-chave: fitoterapia, guaco, metabólitos secundários, biossínteseABSTRACT: Morpho-anatomy, phytochemistry and pharmacology of Mikania glomerata Sprengel: a brief literature review. Medicinal plants have been increasingly used due to their preventive, palliative and curative properties, besides being an alternative therapy that brings a large number of benefits to their users. The species Mikania glomerata belongs to the Asteraceae family and is popularly known as guaco, being employed to treat diseases of the respiratory tract. This study aimed to carry out a literature review about the pharmacology, pharmacobotany and phytochemistry of the secondary metabolites of M. glomerata, particularly coumarin, its biosynthesis and biological actions. The bronchodilator, expectorant, anti-inflammatory and antiallergic actions, as well as the interactions with some antibiotics and anticoagulants, were also described in this study. Key words: phytotherapy, guaco, secondary metabolites, biosynthesis INTRODUÇÃOHá muito tempo as plantas medicinais vêm sendo estudadas na tentativa de descoberta de novos princípios ativos. Plantas medicinais são assim chamadas por apresentarem propriedades curativas e/ou preventivas para determinadas doenças.As referências históricas afirmam que o uso de plantas medicinais faz parte da evolução humana e que essa prática é relatada na maioria das antigas civilizações, sendo a primeira referência escrita encontrada na obra Pen Ts'ao "A Grande Fitoterapia", do chinês Shen Nung, a qual remonta a 2800 a.C (Dorta, 1998). A fitoterapia foi um dos primeiros recursos terapêuticos utilizados pelos povos, além de ser por muito tempo a única terapia disponível ao homem. Em algumas ocasiões as plantas curavam, em outras matavam ou produziam graves efeitos colaterais (De Melo et al., 2009), sendo, portanto, essencial o uso responsável, racional, seguro e não abusivo das mesmas.Fitoterapia significa tratamento de uma dada doença mediante o uso de plantas. Pode-se dizer então que a fitoterapia é uma terapêutica caracterizada pelo uso de plantas medicinais nas diferentes formas farmacêuticas. Emitida pela Agência Nacional de...

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Metabólitos secundários de origem vegetal: uma fonte potencial de fármacos antitrombóticos

Cited by 24 publications

References 51 publications

Preliminary Studies on Anticoagulation and Antiplatelet Activities of Plinia cauliflora (Mart.) Kausel Leaves Extract

Preliminary Studies on Anticoagulation and Antiplatelet Activities of Plinia cauliflora (Mart.) Kausel Leaves Extract

Myracrondruon urundeuva Allemo: Chemical composition, antioxidant activity, antimicrobial activity and inotropic effect

Farmacobotânica, fitoquímica e farmacologia do Guaco: revisão considerando Mikania glomerata Sprengel e Mikania laevigata Schulyz Bip. ex Baker

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