Determination of cetirizine in tablets and compounded capsules: comparative study between CE and HPLC

Bajerski, Lisiane; Sangoi, Maximiliano da Silva; Barth, Thiago; Diefenbach, Isabel Fração; Dalmora, Sérgio Luís; Cardoso, Simone Gonçalves

doi:10.1590/s0100-40422010000100021

Cited by 11 publications

(5 citation statements)

References 20 publications

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“…This trend is shown in Table 5 , where decreasing the pH toward a more acidic environment increases the saturated solubilities of the drugs. CZH is considered a weak acid 23 but under acidic conditions is considered to be zwitterionic.…”

Section: Resultsmentioning

confidence: 99%

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Lipid Cubic Systems for Sustained and Controlled Delivery of Antihistamine Drugs

et al. 2021

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Antihistamines are capable of blocking mediator responses in allergic reactions including allergic rhinitis and dermatological reactions. By incorporating various H 1 receptor antagonists into a lipid cubic phase network, these active ingredients can be delivered locally over an extended period of time owing to the mucoadhesive nature of the system. Local delivery can avoid inducing unwanted side effects, often observed after systematic delivery. Lipid-based antihistamine delivery systems are shown here to exhibit prolonged release capabilities. In vitro drug dissolution studies investigated the extent and release rate of two model first-generation and two model second-generation H 1 antagonist antihistamine drugs from two monoacyglycerol-derived lipid models. To optimize the formulation approach, the systems were characterized macroscopically and microscopically by small-angle X-ray scattering and polarized light to ascertain the mesophase accessed upon an incorporation of antihistamines of varying solubilities and size. The impact of encapsulating the antihistamine molecules on the degree of mucoadhesivity of the lipid cubic systems was investigated using multiparametric surface plasmon resonance. With the ultimate goal of developing therapies for the treatment of allergic reactions, the ability of the formulations to inhibit mediator release utilizing RBL-2H3 mast cells with the propensity to release histamine upon induction was explored, demonstrating no interference from the lipid excipient on the effectiveness of the antihistamine molecules.

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Section: Resultsmentioning

confidence: 99%

“… Chemical structures of (a) monoolein (9.9 MAG) and (b) monopalmitolein (9.7 MAG) both possessing an ester linkage linking the oleic acid chain to the glycerol backbone and the antihistamine drugs (c) DPH, p K a 8.76; 20 (d) AZL, p K a 8.87; 21 (e) CBX, p K a 8.88; 22 and (f) cetirizine dihydrochloride (CZH), p K a 8.00. 23 …”

Section: Introductionmentioning

confidence: 99%

Lipid Cubic Systems for Sustained and Controlled Delivery of Antihistamine Drugs

et al. 2021

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“…Drug testing and analysis is important in the quality and quantity control of pharmaceutical utilities, and therefore, fast, simple and effective analytical methods are required for the analysis of drug molecules [6]. There are many methods previously used for CTZ determination such as electrophoresis [7], high performance liquid chromatography [8], spectrophotometry [9], HPLC/MS [10], spectrofluorimetry [11], and electrochemical methods [12,13]. All these methods, except electrochemical methods, have some drawbacks like time consuming, requirements for more organic solvents and reagents, and experts for handling, and also inclusion of complicated and expensive procedures [14].…”

Section: A D V a N C E D O N L I N E A R T I C L Ementioning

confidence: 99%

Poly (DL-valine) electro-polymerized carbon nanotube paste sensor for determination of antihistamine drug cetirizine

Tigari

Manjunatha

Pushpanjali

et al. 2020

J. Electrochem. Sci. Eng.

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Poly (DL-valine) modified multiwalled carbon nanotube paste sensor (PVLMCNTPS) was prepared by electro-polymerization route. PVLMCNTPS and bare multiwalled carbon nanotube paste sensor (BMCNTPS) morphologies and sensing properties for cetirizine (CTZ) were confirmed through a field emission scanning electron microscope (FE-SEM) and electrochemical studies, respectively. In contrast to BMCNTPS, PVLMCNTPS surface composite creates an electrocatalytic impact on the oxidation of CTZ. PVLMCNTPS properties were optimized using parameters such as accumulation time, number of polymerization cycles, solution pH, and scan rate. The optimized PVLMCNTPS was applied for the determination of cetirizine in 0.1 M phosphate buffer solution (PBS) of pH 7.0, using cyclic voltammetry (CV). It is shown that PVLMCNTPS provided analytical linearity from 2.0 to 80 µM, with a detection limit of 0.11 µM for CTZ determination. PVLMCNTPS is found highly selective for CTZ in presence of some interfering organic molecules. The stable and selective PVLMCNTPS was applied for CTZ determination in pharmaceutical pills with satisfactory results.

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“…It is currently marketed as a racemate. Cetirizine dihydrochloride can be found in a range of pharmaceutical forms such as tablets, compounded capsules, syrups, drops and oral liquids [2,3,4,5,6,7]. The tablets are more preferred over the oral liquid formulation.…”

Section: Introductionmentioning

confidence: 99%

A Novel Two-Step Liquid-Liquid Extraction Procedure Combined with Stationary Phase Immobilized Human Serum Albumin for the Chiral Separation of Cetirizine Enantiomers along with M and P Parabens

2016

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Abstract:The research into the separation of drug enantiomers is closely related to the safety and efficiency of the drugs. The aim of this study was to develop a simple and validated HPLC method to analyze cetirizine enantiomers. In the case of liquid dosage forms, besides the active substance in large amounts there are usually also inactive ingredients such as methyl-and propylparaben. Unfortunately, these compounds can interfere with the analyte, inter alia during chiral separation of the analyte enantiomers. The proposed innovative two-step liquid-liquid extraction procedure allowed for the determination of cetirizine enantiomers (along with M and P parabens) also in liquid dosage forms. The main focus of this study was the chromatographic activity of cetirizine dihydrochloride on the proteinate-based chiral stationary phase. The chromatographic separation of cetirizine enantiomers was performed on an immobilized human serum albumin (HSA) column for the first time. Measurements were performed at a wavelength of 227 nm. Under optimal conditions, baseline separation of two enantiomers was obtained with 1.43 enantioseparation factor (α) and 1.82 resolution (R s ). Finally, the proposed method was successfully applied to the selected pharmaceutical formulations.

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Determination of cetirizine in tablets and compounded capsules: comparative study between CE and HPLC

Cited by 11 publications

References 20 publications

Lipid Cubic Systems for Sustained and Controlled Delivery of Antihistamine Drugs

Lipid Cubic Systems for Sustained and Controlled Delivery of Antihistamine Drugs

Poly (DL-valine) electro-polymerized carbon nanotube paste sensor for determination of antihistamine drug cetirizine

A Novel Two-Step Liquid-Liquid Extraction Procedure Combined with Stationary Phase Immobilized Human Serum Albumin for the Chiral Separation of Cetirizine Enantiomers along with M and P Parabens

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