Development of dissolution method for benznidazole tablets

Abstract

Recebido em 8/9/08; aceito em 14/4/09; publicado na web em 17/9/09The aim of this work was the development of a dissolution method for benznidazole (BNZ) tablets. Three different types of dissolution media, two stirring speeds and apparatus 2 (paddle) were used. The accomplishment of the drug dissolution profiles was compared through the dissolution efficiency. The assay was performed by spectrophotometry at 324 nm. The better conditions were: sodium chloride\ hydrochloride acid buffer pH 1.2 with stirring speed of 75 rpm, volume of 900 mL and paddle as apparatus. Ahead of the results it can be concluded that the method developed consists in an efficient alternative for assays of dissolution for benznidazole tablets.

Caracterização físico-química do fármaco antichagásico benznidazol

“…19 A falta de informações experimentais sobre estas medidas para o BNZ tem causado interpretações dúbias sobre a classificação biofarmacêutica deste fármaco que, segundo publicações recentes, chegou a ser inserido na categoria II (baixa solubilidade e alta permeabilidade) e III (alta solubilidade e baixa permeabilidade). 20,21 O valor de LogP ow do BNZ, embora relativamente alto, ainda não garante uma imediata permeação da molécula, que só ocorreria com substâncias com LogP ow superiores a 1,7.…”

Development of a LC–MS/MS methodology for the monitoring of the antichagasic drug benznidazole in human urine

“…Under the optimal mentioned conditions, the analyte was eluted at 2.88 min (Fig. 2) from the column within a 5.0 min total run cycle, which were shorter than the ones recently reported by other authors [33,34,36].…”

“…However, it has been well documented the limitations of some of these analytical approaches to detect interferences and overcome some serious problems related to sample complexity. Moreover, only a few authors have developed LC-UV-based methodologies to quantify BNZ in plasma and animal urine for further implementation in human pharmacokinetic and health-safety studies [34][35][36][37]. A recent report, the unique one to the best of our knowledge, has been developed for applications in urine samples for studies in humans [37], with limited descriptions of analytical method performance.…”

Cocrystal Polymorphs and Solvates of the Anti-Trypanosoma cruzi Drug Benznidazole with Improved Dissolution Performance

“…The usual methodology to determine the BZN solubility considers measuring the transmitted UV/vis intensity at the absorption maximum. , This strategy cannot be directly applied to the BZNSAL cocrystal, because the coformer absorption spectrum also needs to be considered. Figure S5 shows the absorption spectra of BZN and SAL.…”