Aspectos mecanísticos da bioatividade e toxicidade de nitrocompostos

Paulai, Fávero Reisdorfer; Serrano, Sı́lvia Helena Pires; Tavares, Leoberto Costa

doi:10.1590/s0100-40422009000400032

Cited by 56 publications

(41 citation statements)

References 33 publications

(55 reference statements)

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“…22 Cabe ressaltar que todos os derivados quando avaliados frente a linfócitos do hospedeiro não apresentaram efeitos tóxicos na dose testada (50 μM).…”

Section: Atividade Anti-leishmania (L) Amazonensis E Anti-t Cruziunclassified

Síntese, caracterização e estudo da atividade inibitória de novas dialquilfosforilarilidrazonas sobre o crescimento de tripanossomatídeos

Nogueira¹,

Lima²,

DaCosta³

et al. 2011

Quím. Nova

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“…22 Cabe ressaltar que todos os derivados quando avaliados frente a linfócitos do hospedeiro não apresentaram efeitos tóxicos na dose testada (50 μM).…”

Section: Atividade Anti-leishmania (L) Amazonensis E Anti-t Cruziunclassified

Síntese, caracterização e estudo da atividade inibitória de novas dialquilfosforilarilidrazonas sobre o crescimento de tripanossomatídeos

Nogueira¹,

Lima²,

DaCosta³

et al. 2011

Quím. Nova

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“…On a carbon paste electrode, the oxidation potential of amodiaquine is 0.52 V (vs. Ag/AgCl), while that of an electrode modified with DNA is 0.60 V (vs. Ag/AgCl). According to the literature, 29,30 species that are electrochemically oxidized at potentials below 1.0 V can also be oxidized in biological media.…”

Section: Electrochemical Behaviormentioning

confidence: 99%

Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation

Arguelho¹,

Alves²,

Stradiotto³

et al. 2010

Quím. Nova

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Recebido em 4/9/09; aceito em 3/2/10; publicado na web em 18/6/10The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the amodiaquine with the guanine group. Theoretical calculations for optimization of geometry, and DFT analyses and on the electrostatic potential map (EPM), were used in the investigation of adduct formation between amodiaquine and DNA.

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“…Nevertheless, the use of these compounds has never discontinued since continued being used in various therapeutic classes, such as antibacterial, anti-inflammatory, antihypertensive, antineoplastic and used in veterinary medicine [12][13][14] .…”

mentioning

confidence: 99%

Linseed (Linum usitatissimum L.) as a Biocatalyst for Reduction of Nitroaromatic Compounds

Tavares¹,

Lemos²,

Arriaga³

et al. 2014

Orient. J. Chem.

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Aspectos mecanísticos da bioatividade e toxicidade de nitrocompostos

Cited by 56 publications

References 33 publications

Síntese, caracterização e estudo da atividade inibitória de novas dialquilfosforilarilidrazonas sobre o crescimento de tripanossomatídeos

Síntese, caracterização e estudo da atividade inibitória de novas dialquilfosforilarilidrazonas sobre o crescimento de tripanossomatídeos

Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation

Linseed (Linum usitatissimum L.) as a Biocatalyst for Reduction of Nitroaromatic Compounds

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