Micropartículas nanorrevestidas contendo um fármaco modelo hidrofóbico: preparação em etapa única e caracterização biofarmacêutica

Domingues, Gislane Scholze; Guterres, Sı́lvia Stanisçuaski; Beck, Ruy Carlos Ruver; Pohlmann, Adriana Raffin

doi:10.1590/s0100-40422008000800009

Cited by 19 publications

(12 citation statements)

References 16 publications

(34 reference statements)

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“…However, some previous reports have described that a segregation of the drug/materials during the spray-drying process can occur, depending on the raw material [33] or the parameters of the process [39]. …”

Section: Resultsmentioning

confidence: 99%

Hydrogels containing redispersible spray-dried melatonin-loaded nanocapsules: a formulation for transdermal-controlled delivery

et al. 2012

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The aim of the present study was to develop a transdermal system for controlled delivery of melatonin combining three strategies: nanoencapsulation of melatonin, drying of melatonin-loaded nanocapsules, and incorporation of nanocapsules in a hydrophilic gel. Nanocapsules were prepared by interfacial deposition of the polymer and were spray-dried using water-soluble excipients. In vitro drug release profiles were evaluated by the dialysis bag method, and skin permeation studies were carried out using Franz cells with porcine skin as the membrane. The use of 10% (w/v) water-soluble excipients (lactose or maltodextrin) as spray-drying adjuvants furnished redispersible powders (redispersibility index approximately 1.0) suitable for incorporation into hydrogels. All formulations showed a better controlled in vitro release of melatonin compared with the melatonin solution. The best controlled release results were achieved with hydrogels prepared with dried nanocapsules (hydrogels > redispersed dried nanocapsules > nanocapsule suspension > melatonin solution). The skin permeation studies demonstrated a significant modulation of the transdermal melatonin permeation for hydrogels prepared with redispersible nanocapsules. In this way, the additive effect of the different approaches used in this study (nanoencapsulation, spray-drying, and preparation of semisolid dosage forms) allows not only the control of melatonin release, but also transdermal permeation.

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Section: Resultsmentioning

confidence: 99%

Hydrogels containing redispersible spray-dried melatonin-loaded nanocapsules: a formulation for transdermal-controlled delivery

et al. 2012

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“…Contudo, a desaglomeração das partículas não foi completa, prevalecendo aglomerados com diâmetros médios muito maiores quando comparados ao diâmetro médio de partículas primárias de sílica Aerosil ® (7,0 nm a 40,0 nm). O diâmetro médio em volume do Aerosil ® 200 é D 50 : 22,0 μm [37].…”

Section: Q3(x)[%] Dq3(x)[%]unclassified

Sílica gel obtida de escória de alto forno: Marabá, Pará

2015

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ResumoSílica gel com propriedades similares à sílica comercial foi obtida a partir de escória de alto forno (EAF), utilizando digestão com ácido clorídrico. A EAF-sílica obtida foi caracterizada por diferentes técnicas, mostrando-se amorfa, com pureza 99,7% e área específica 282 m 2 /g. Apresentou caráter hidrofílico alto (12,27%), com água de constituição de ~ 6,18%, o que foi confirmado pela perda de massa durante a análise termogravimétrica. As partículas de EAF-sílica apresentaram tamanhos micrométricos (< 1 µm) em forma de agregados, distribuição granulométrica unimodal e D 50 7,0 µm. Palavras-chave: escória de alto forno, sílica gel, síntese. Abstract Silica gel with similar properties to commercial silica was obtained from blast furnace slag (EAF) using digestion with

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“…Regarding the mechanism of drug release from these nanoparticle-coated microparticles, Domingues and coworkers showed a controlled release of indomethacin, a nonsteroidal anti-inflammatory drug, from nanocapsule-coated microparticles prepared in one step compared to the pure drug [34]. The drug release profiles fit to the monoexponential equation and the Korsmeyer-Peppas model, which allowed the proposition of a non-Fickian release mechanism dependent on the nanocapsule-coated microparticle desagglomeration [34].…”

Section: Preparing Innovative Nanoparticle-coated Microparticlesmentioning

confidence: 99%

“…The drug release profiles fit to the monoexponential equation and the Korsmeyer-Peppas model, which allowed the proposition of a non-Fickian release mechanism dependent on the nanocapsule-coated microparticle desagglomeration [34].…”

Section: Preparing Innovative Nanoparticle-coated Microparticlesmentioning

confidence: 99%

Spray-drying technique to prepare innovative nanoparticulated formulations for drug administration: a brief overview

2009

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Polymeric nanoparticle systems (nanocapsules and nanospheres) present potential applications as drug delivery systems. Nevertheless, their full applications have not been exploited due to their limited shelf life when stored in aqueous medium. Drying polymeric nanoparticles using spray-drying represents a promising platform to improve the physicochemical stability of formulations and/or to control the release of hydrophilic and lipophilic drugs. This article presents a brief overview of the most recent and ongoing research in the use of spray-drying process to prepare and/or to dry polymeric nanoparticles formulations intended for drug administration.

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Micropartículas nanorrevestidas contendo um fármaco modelo hidrofóbico: preparação em etapa única e caracterização biofarmacêutica

Cited by 19 publications

References 16 publications

Hydrogels containing redispersible spray-dried melatonin-loaded nanocapsules: a formulation for transdermal-controlled delivery

Hydrogels containing redispersible spray-dried melatonin-loaded nanocapsules: a formulation for transdermal-controlled delivery

Sílica gel obtida de escória de alto forno: Marabá, Pará

Spray-drying technique to prepare innovative nanoparticulated formulations for drug administration: a brief overview

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