Determinação voltamétrica de ciclamato de sódio em produtos dietéticos empregando um eletrodo de diamante dopado com boro

Medeiros, Roberta Antigo; Carvalho, Adriana Evaristo de; Rocha‐Filho, Romeu C.; Fatibello‐Filho, Orlando

doi:10.1590/s0100-40422008000600024

Cited by 24 publications

(12 citation statements)

References 20 publications

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“…There is a great concern regarding the safety of ingesting the cyclamate/saccharin mixture and investigations concerning their effects on the human beings are gaining importance (MEDEIROS, 2007). So far, the results from many studies carried out to verify the toxicity of these sweeteners indicate few physiopathological effects even when ingesting high doses (FATIBELLO-FILHO et al, 1996;MEDEIROS, 2007;YAN et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…So far, the results from many studies carried out to verify the toxicity of these sweeteners indicate few physiopathological effects even when ingesting high doses (FATIBELLO-FILHO et al, 1996;MEDEIROS, 2007;YAN et al, 2005). In spite of the fact that these sweeteners recently had their limits for maximum use in food products reduced by the National Agency of Sanitary Vigilance (ANVISA) (BRASIL, 2008), respecting the established limits, they can be used by the food industries and be normally ingested.…”

Section: Discussionmentioning

confidence: 99%

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Physical-chemical, caloric and sensory characterization of light jambolan (Syzygium cumini Lamarck) jelly

Lago-Vanzela¹,

Santos²,

Lima³

et al. 2011

Ciênc. Tecnol. Aliment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Physical-chemical, caloric and sensory characterization of light jambolan (Syzygium cumini Lamarck) jelly

Lago-Vanzela¹,

Santos²,

Lima³

et al. 2011

Ciênc. Tecnol. Aliment.

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“…The use of this type of pretreatment allows achieving very low detection and quantification limits and high data reproducibility for the analysis of several substances in aqueous solutions [5][6][7][8][9][10][11][12][13][14][15][16][17][18]. The pretreatment procedure commonly used consists in either a 30 min potentiostatic polarization at -3.0 V versus the hydrogen electrode in the same solution (HESS) [1-9, 11, 14] or a galvanostatic polarization (at least -0.5 A cm -2 for at least 60 s) [10,12,13,[15][16][17][18]. Such polarizations produce intense hydrogen evolution, which can be accompanied by an undesirable increase in the solution temperature depending on the total charge passed.…”

Section: Introductionmentioning

confidence: 99%

On the activation and physical degradation of boron-doped diamond surfaces brought on by cathodic pretreatments

et al. 2010

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The electrochemical activation and physical degradation of boron-doped diamond (BDD) electrodes with different boron doping levels after repeated cathodic pretreatments are reported. Galvanostatic cathodic pretreatment passing up to -14000 C cm -2 in steps of -600 C cm -2 using -1 A cm -2 caused significant physical degradation of the BDD surface, with film detachment in some areas. Because of this degradation, a great increase in the electrochemically active area was observed in Tafel plots for the hydrogen evolution reaction (HER) in acid media. The minimum cathodic pretreatment needed for the electrochemical activation of the BDD electrodes without producing any observable physical degradation on the BDD surfaces was determined using electrochemical impedance spectroscopy (EIS) measurements and cyclic voltammetry: -9 C cm -2 , passed at -1 A cm -2 . This optimized cathodic pretreatment can be safely used when electrochemical experiments are carried out on BDD electrodes with doping levels in the range between 800 and 8000 ppm.

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“…Recently, thin films of boron-doped diamond (BDD) emerged as a unique electrode material for several electrochemical applications, especially in electroanalysis. [26][27][28][29][30][31][32][33] BDD electrodes possess very attractive properties, which are significantly different from those of other conventional electrodes, e.g. glassy-carbon or platinum electrodes.…”

Section: Introductionmentioning

confidence: 99%

Square-wave voltammetric determination of acetylsalicylic acid in pharmaceutical formulations using a boron-doped diamond electrode without the need of previous alkaline hydrolysis step

Sartori¹,

Medeiros²,

Rocha‐Filho³

et al. 2009

J. Braz. Chem. Soc.

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Neste trabalho descreve-se a determinação do ácido acetilsalicílico (ASA) em formulações farmacêuticas empregando voltametria de onda quadrada (SWV) e um eletrodo de diamante dopado com boro (BDD). Neste método, ASA é determinado diretamente em solução de H 2 SO 4 0,01 mol L -1 , sem a necessidade da hidrólise alcalina. Foi obtido um único pico de oxidação no potencial de 1,97 V vs. Ag/AgCl (KCl 3,0 mol L -1 ) com características de uma reação irreversível. A curva analítica obtida é linear na faixa de concentração ASA de 2,50 × 10 -6 -1,05 × 10 -4 mol L -1 , com um limite de detecção de 2,0 µmol L -1 . O desvio padrão relativo foi menor que 1,4% para uma solução de ASA 45 µmol L -1 (n = 10). O método proposto foi aplicado com sucesso para a determinação de ASA em várias formulações farmacêuticas e os resultados obtidos foram concordantes com um método oficial da Farmacopéia Britânica, a um nível de confiança de 95%.In this paper the determination of acetylsalicylic acid (ASA) in pharmaceutical formulations using square-wave voltammetry (SWV) and a boron-doped diamond electrode (BDD) is described. By this proposed method, ASA is directly determined in a 0.01 mol L -1 H 2 SO 4 solution without the need of a previous time-consuming alkaline hydrolysis step. A single oxidation peak at a potential of 1.97 V vs. Ag/AgCl (3.0 mol L -1 KCl) with the characteristics of an irreversible reaction was obtained. The obtained analytical curve is linear in the ASA concentration range 2.50 × 10 -6 -1.05 × 10 -4 mol L -1 , with a detection limit of 2.0 µmol L -1 . The obtained relative standard deviation was smaller than 1.4% for a 45 µmol L -1 ASA solution (n = 10). The proposed method was applied with success in the determination of ASA in several pharmaceutical formulations; the obtained results were in close agreement, at a 95% confidence level, with those obtained using an official method of the British Pharmacopoeia.Keywords: acetylsalicylic acid determination, boron-doped diamond electrode, square-wave voltammetry, pharmaceutical formulations IntroductionAcetylsalicylic acid (ASA), shown in Figure 1, more popularly known as aspirin, is one of the oldest medicines that still plays an important role in modern therapeutics. It is widely employed in pharmaceutical formulations for the relief of headaches, fever, muscular pain, and inflammation due to arthritis or injury. It was first synthesized in 1897, by Felix Hoffmann, in the Farbenfabrik Freidrich Bayer laboratories, in Elberfeld, Germany. 1,2 The high consumption of this substance all over the world 3,4 indicates the importance of the development of new analytical methods to assess not only the quality but also the authenticity of the product.The rate of decomposition of ASA to salicylic acid (SA) and acetic acid (AA) is dependent on solution pH and temperature. In the pH range 11-12 ASA is quickly hydrolyzed, in the pH range 4-8 its hydrolysis rate is slow, and maximum stability is attained at pH 2-3. 5 Commonly, ASA is indirectly determined after its conversion to SA ...

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Determinação voltamétrica de ciclamato de sódio em produtos dietéticos empregando um eletrodo de diamante dopado com boro

Cited by 24 publications

References 20 publications

Physical-chemical, caloric and sensory characterization of light jambolan (Syzygium cumini Lamarck) jelly

Physical-chemical, caloric and sensory characterization of light jambolan (Syzygium cumini Lamarck) jelly

On the activation and physical degradation of boron-doped diamond surfaces brought on by cathodic pretreatments

Square-wave voltammetric determination of acetylsalicylic acid in pharmaceutical formulations using a boron-doped diamond electrode without the need of previous alkaline hydrolysis step

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