Purificação e caracterização da beta-lapachona e estudo de estabilidade dos cristais em diferentes condições de armazenamento

Abstract

PURIFICATION AND CHARACTERIZATION OF β-LAPACHONE AND STABILITY STUDY OF THE CRYSTALS UNDER DIFFERENT STORING CONDITIONS. The β-lapachone is a product obtained from the Ipê Roxo tree [Tabebuia avellandae], which has proved its excellent antineoplasic potential acting through a particular mechanism of apoptosis against various cancer types. This study aims at determining the identity card of β-lapachone by means of physico-chemical and pharmaco-technical characterization. A purifying process has been performed, as well as the isolation of a contaminant, its isomer α-lapachone. A stability study was also performed, determining the ideal storing conditions for β-lapachone, essential for the ongoing pre-formulation studies for obtaining the different classic pharmaceutical forms and modified release systems.

Assay and physicochemical characterization of the antiparasitic albendazole

“…The angle of repose technique and flow time confirmed the poor flow of ABZ powder, since there was no flow (Alves et al, 2008). Based on all these results from powder rheology, ABZ can be classified as a poor-flow powder, and these findings are of great importance for the pre-formulation study required in drug development (Medeiros, 2010).…”

“…The HI is also a measure of flow; values smaller than 1.25 indicate good flow, values higher than 1.5 indicate poor flow, and values between 1.25 and 1.5 indicate that lubricants are required to improve drainage. The HI values for ABZ01, ABZ02, and ABZ03 were 1.57, 1.63, and 1.55, respectively, thus classifying them as poor-flow powders (Alves et al, 2008).…”

“…The relationship between the mass (g) and the volume (mL) occupied by the powder before and after compression determined the apparent density (ApD) and the compression density (CpD), respectively. The Hausner index (HI) and the Carr index (CI) were calculated using the following equations: HI = ApD/CpD and CI = (CpD -ApD)/CpD × 100 (USP, 2007;Soares Sobrinho et al, 2008;Alves et al, 2008).…”

Solid-state thermal and spectroscopic studies of the anti-inflammatory drug sulindac using UV–Vis, MIR, NIR, DSC, simultaneous TG–DSC, and the coupled techniques TG-EGA-MIR and DSC–optical microscopy

“…The physicochemical characterization of commercial drugs is important for standardization and evaluation of purity, making it suitable for the study of preformulation [12], interactions with excipients [13], decomposition kinetics [14], polymorphism [15], etc. The use of evolved gas analysis (EGA) regarding the products derived from the thermal decomposition of the active ingredients is important because these products may appear as impurities in commercial drugs [16,17] which makes the use of coupled TG-EGA-MIR a valuable tool, and it is currently employed in the study of thermal degradation of different materials [18,19].…”

Physical-chemical properties and microstructural characterization of traditional mexican chili (Capsicum annuum L.) powders

“…Flowability is affected by many factors such as particle size, shape, density, chemical composition, and moisture content. Powder properties are commonly determined under loading conditions of gravity, by means of angle of repose, standardized flow rate, aerated and tapped bulk density values, beside of Carr Index and Hausner ratio (Zou and Brusewitz, 2002;Thalberg et al, 2004;Cavalcante-Alves et al, 2008;Emery et al, 2009;Perea-Flores et al, 2010). Density is a basic property for materials and industrial processes characterization, storage selection, packaging, and distribution conditions.…”