Síntese de aminoglicosídeos, precursores de pseudo-dissacarídeos potencialmente ativos

Abstract

Recebido em 16/11/98; aceito em 27/7/99 SYNTHESIS OF AMINOGLYCOSIDES AS PRECURSORS OF POTENTIALLY ACTIVES PSEUDODISACCHARIDES. This work describes the syntheses of O-protected aminoglycosides as an important block building for the preparation of potential bioactive pseudodisaccharide. The new O-protected methyl 3-amino-3-deoxy-α α α α α-D-glycopyranoside 4 and methyl 2-amino-2-deoxy-α α α α α-D-glycopyranoside 5 were prepared, respectively, in five and four steps. All compounds were obtained in good yield and characterized by spectral data ( 1 H and 13 C NMR, MS, IR) and elemental analysis.