Sesquiterpenos das algas marinhas Laurencia Lamouroux (Ceramiales, Rhodophyta) 1: Significado ecológico

Pereira, Renato Crespo; Teixeira, Valéria Laneuville

doi:10.1590/s0100-40421999000300015

Cited by 17 publications

(8 citation statements)

References 42 publications

(65 reference statements)

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“…The members of this complex, in particular Laurencia s.s., are prolific synthesizers of structurally elaborate halogenated secondary metabolites and have been reported to produce a numerous diversity of unique compounds, especially terpenes (Martín & Darias, 1978;Erickson, 1983;Pereira & Teixeira, 1999). Although the function of these secondary metabolites has not yet been clearly defined, it has been suggested that these metabolites play a major role in mediating ecological interactions such as algae/herbivore interactions (Hay et al, 1987, Hay & Steinberg, 1992, with these compounds acting as a defense against being eaten or as a deterrent against epibiota, i.e., an antifouling activity (da Gama et al, 2002;Cassano et al, 2008;Lhullier et al, 2009), or protection against pathogens (König & Wright, 1997).…”

Section: Introductionmentioning

confidence: 99%

Overview of the taxonomy and of the major secondary metabolites and their biological activities related to human health of the Laurencia complex (Ceramiales, Rhodophyta) from Brazil

Fujii¹,

Cassano²,

Stein³

et al. 2011

Rev. bras. farmacogn.

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Abstract:In Brazil, the Laurencia complex is represented by twenty taxa: Laurencia s.s. with twelve species, Palisada with four species (including Chondrophycus furcatus now that the proposal of its transference to Palisada is in process), and Osmundea and Yuzurua with two species each. The majority of the Brazilian species of the Laurencia complex have been phylogenetically analyzed by 54 rbcL sequences, including five other Rhodomelacean species as outgroups. The analysis showed that the Laurencia complex is monophyletic with high posterior probability value. The complex was separated into five clades, corresponding to the genera: Chondrophycus, Laurencia, Osmundea, Palisada, and Yuzurua. A bibliographical survey of the terpenoids produced by Brazilian species showed that only six species of Laurencia and five of Palisada (including C. furcatcus) have been submitted to chemical analysis with 48 terpenoids (47 sesquiterpenes and one triterpene) isolated. No diterpenes were found. Of the total, 23 sesquiterpenes belong to the bisabolane class and eighteen to the chamigrene type, whose biochemical precursor is bisabolane, two are derived from lauranes and four are triquinols. Despite the considerable number of known terpenes and their ecological and pharmacological importance, few experimental biological studies have been performed. In this review, only bioactivities related to human health were considered.

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Section: Introductionmentioning

confidence: 99%

Overview of the taxonomy and of the major secondary metabolites and their biological activities related to human health of the Laurencia complex (Ceramiales, Rhodophyta) from Brazil

Fujii¹,

Cassano²,

Stein³

et al. 2011

Rev. bras. farmacogn.

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“…Lamouroux sensu lato (Ceramiales, Rhodophyta) are an extremely rich source of halogenated secondary metabolites with diverse structural features (Fenical & Norris, 1975;Martín & Darias, 1978;Erickson, 1983;Pereira & Teixeira, 1999) that can be divided into two groups according to their biogenetic origin. The fi rst one is the nonterpenoid group, which contains the acetogenins derived from the metabolism of fatty acids.…”

Section: Introductionmentioning

confidence: 99%

“…The fi rst one is the nonterpenoid group, which contains the acetogenins derived from the metabolism of fatty acids. The other one is the terpenoid group, in which the sesquiterpenes are the most abundant, but also containing diterpenes and triterpenes (Pereira & Teixeira, 1999;Fernández et al, 2005;Cen-Pacheco et al, 2011a).…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of the corps en cerise in several species of Laurencia (Ceramiales, Rhodophyta) from the Atlantic Ocean

Fujii¹,

Cassano

Sentíes³

et al. 2012

Rev. bras. farmacogn.

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Different species of Laurencia have proven to be a rich source of natural products yielding interesting bioactive halogenated secondary metabolites, such as terpenoids and acetogenins. It is shown that such compounds are accumulated in the spherical, reniform to claviform refractive inclusions called corps en cerise (CC), which are intensively osmiophilic and located mainly in the cortical cells of the thalli and also in trichoblast cells. Up to now, it was believed that CC were present only in these two kinds of cells. Recently, however, a species of Laurencia, L. marilzae, with CC in all cells of the thallus, i.e., cortical, medullary, including the pericentral and axial cells, as well as in the trichoblasts, was described from the Canary Islands, and subsequently also reported to Brazil and Mexico. Within the Laurencia complex, only Laurencia species produce CC. Since the species of Laurencia are targets of interest for the prospection of bioactive substances due to their potential antibacterial, antifungal, anticholinesterasic, antileishmanial, cytotoxic, and antioxidant activities, the present paper carries out a comparative analysis of the corps en cerise in several species of Laurencia from the Atlantic Ocean to obtain basic information that can support natural product bioprospection projects. Our results show that the number and size of the CC are constant within a species, independent of the geographical distribution, corroborating their use for taxonomical purposes to differentiate groups of species that present a lower number from those that have a higher number. In this regard, there was a tendency for the number of CC to be higher in some species of Laurencia from the Canary Islands. The presence of CC can also be used to distinguish species in which these organelles are present in all cells of the thallus from those in which CC are restricted to the cortical cells. Among the species analyzed, L. viridis displayed the most varied secondary metabolites composition, such as sesquiterpenes, diterpenes, triterpenes, all of which showed potent antiviral, cytotoxic, and antitumoral activities, including protein phosphatase type 2A (PP2A) inhibitory effects.

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“…A produção dos metabólitos pode ser uma resposta às pressões ambientais que, concomitantemente, aumenta o valor adaptativo dessas algas que os produzem (Pereira, 1999 Nippostrongylus brasiliensis para o ensaio (Davyt et al, 2001).…”

Section: As Algas Marinhas E Seu Potencial Farmacológicounclassified

“…The members of this complex, in particular Laurencia s.s., are prolific synthesizers of structurally elaborate halogenated secondary metabolites and have been reported to produce a numerous diversity of unique compounds, especially terpenes (Martín & Darias, 1978;Pereira & Teixeira, 1999). Although the function of these secondary metabolites has not yet been clearly defined, it has been suggested that these metabolites play a major role in mediating ecological interactions such as algae/herbivore interactions (Hay et al, 1987, Hay & Steinberg, 1992, with these compounds acting as a defense against being eaten or as a deterrent against epibiota, i.e., an antifouling activity (da Gama et al, 2002;Cassano et al, 2008;Lhullier et al, 2009), or protection against pathogens (König & Wright, 1997).…”

mentioning

confidence: 99%

Avaliação das atividades biológicas e composição química dos extratos de algas vermelhas do gênero Laurencia (Rhodomelaceae, Ceramiales) do litoral do Espírito Santo, Brasil

Stein¹

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AGRADECIMENTOSÀ Deus por ter me dado coragem e força.Aos meus pais por terem me apoiado e acreditado.À minha orientadora Dra. Mutue Toyota Fujii pela oportunidade e confiança, por ter abraçado cada etapa junto comigo.Ao Prof. Dr. Pio Colepicolo por ter me acolhido e me adotado como aluna em seu laboratório, sem o qual este trabalho não teria sido realizado.Aos amigos do LabPio atualmente presentes ou que já seguiram seu caminho Cícero Lima, Diego Decleva, Eliézer Estefanelo, João Vasconcelos, Renato Lahos, Luiz Fernando Mendes, Dinaelza Castelo, Paula Laranjeira, pela convivência diária, troca de experiências e os vários momentos de lazer. Vocês se tornaram minha família paulistana! À Patrícia Miranda pela acolhida no laboratório, pela amizade e por cada coisa que me ensinou. À Fabi Dörr pela amizade, confidência e o treinamento no GC-MS.Ao Daniel Andreguetti pela companhia, parceria, amizade e alegria no trabalho. Espero que possamos render muitos papers juntos! À Luiza Marques pela paciência com as incansáveis dúvidas químicas! À Angela Tonon pelos vários momentos de alegria passados juntas. À Vanessa Gressler pelo direcionamento no trabalho, pelas dúvidas sanadas e cada trabalho realizado.Ao Diogo Silva pelas dicas no processamento das amostras.Ao Leonardo Villela pela dedicação em tudo que faz e pela constante disposição em sanar cada dúvida ou problema.Ao Felipe Kurachina pelo companheirismo e disposição para o trabalho com os microorganismos.Ao Ed que está sempre a escutar nossos problemas e resolver pepinos. Obrigada também pelo "cuidar" de cada um dentro do lab.À Sandrinha que traz sempre alegria, palavras de força e comidas deliciosas, obrigada pela grande contribuição com os materiais de trabalho.Ao Dr. Ernani Pinto pela colaboração e por deixar sempre seu laboratório à disposição.Ao Dr. Maurício Yonamine por disponibilizar a biblioteca do GC do LAT. À Beatriz (LAT) pela troca de experiências, pelas conversas construtivas e por tornar sempre disponível o equipamento para uso.Ao Dr. Guilherme L. Indig por me ensinar a trabalhar com células humanas e acreditar que podíamos publicar em tão pouco tempo.Ao Dr. Maurício S. Baptista por disponibilizar seu laboratório de cultura.À Cleidiane Rocha pela amizade, treinamento e colaboração nos trabalhos com as células humanas.Ao Marcos Roberto pela paciência nesta fase final e ajuda com as referências.À Dra. Nair Yokoya por disponibilizar o laboratório de cultura de algas no IBot.À Neide, Nilzete, Elizete e Zé pelas diversas contribuições nas etapas desenvolvidas no IBot.A todos os colegas do alojamento do IBot que me acolheram nos primeiros momentos de permanência em São Paulo.Ao Kleber Renan pela amizade construída, pelos "rangos brutos" e por estar sempre pronto a ajudar.À Diógina Barata pela calorosa recepção, companheirismo e pelo "guia básico de sobrevivência em Sampa". À Elaine Cardoso pelo direcionamento e colaboração e à Maura pela ajuda no desenvolvimento do ensaio anticolinesterásico.Ao Levi Machado pelo direcionamento no ensaio com fitopatógeno.Ao Leon...

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Sesquiterpenos das algas marinhas Laurencia Lamouroux (Ceramiales, Rhodophyta) 1: Significado ecológico

Cited by 17 publications

References 42 publications

Overview of the taxonomy and of the major secondary metabolites and their biological activities related to human health of the Laurencia complex (Ceramiales, Rhodophyta) from Brazil

Overview of the taxonomy and of the major secondary metabolites and their biological activities related to human health of the Laurencia complex (Ceramiales, Rhodophyta) from Brazil

Comparative analysis of the corps en cerise in several species of Laurencia (Ceramiales, Rhodophyta) from the Atlantic Ocean

Avaliação das atividades biológicas e composição química dos extratos de algas vermelhas do gênero Laurencia (Rhodomelaceae, Ceramiales) do litoral do Espírito Santo, Brasil

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