Background: Anal fistula is by definition the communication between the rectum or anal
canal with the perineal region, which may be epithelialized and has
cryptoglandular origin in 90% of cases. There are a large number of
techniques for successfully treating trans-sphincteric fistulas of 20-50%,
including primary sphincteroplasty, but it is not clear whether the material
used would influence the outcome. Aim: To analyze the efficacy of polydioxanone and polypropylene wire in primary
post-fistulotomy sphincteroplasty in the treatment of trans-sphincteric
fistulas in rats. Methods:Thirty Wistar rats had transfixation of the anal sphincter with steel wire,
which remained for 30 days for the development of the anal fistula. After
this period, it was removed and four groups were formed: A (control) without
treatment; B (fistulotomy) submitted to such procedure and curettage only; C
(polidioxanone) in which sphincteroplasty was performed after fistulotomy
with polydioxanone wire; D (polypropylene) submitted to the same treatment
as group C, but with polypropylene wire. After 30 days, euthanasia and
removal of the specimens were performed for qualitative histopathological
analysis, measurement of the area between the muscular cables edges and
evaluation of the degree of local fibrosis. Results: There was persistence of the anal fistula in all animals of group A. There
were no significant differences between groups B, C and D regarding the
distance of the muscular cables (p=0.078) and the degree of fibrosis caused
by the different treatments (p=0.373). Conclusions:There was no difference between polydioxanone and polypropylene wires in
post-fistulotomy primary sphincteroplasty, and this technique was not
superior to simple fistulotomy in relation to the distance of the muscular
cables nor did it present differences in relation to the degree of local
fibrosis.