Efeitos da radioterapia no tecido ósseo

Cunha, Samantha Seara Da; Sarmento, Viviane Almeida; Ramalho, Luciana Maria Pedreira; Freitas, André Carlos de; Almeida, D.; Tavares, Maria Eulina; Souza, J. C. S.; Veeck, Elaine Bauer; Costa, Nilza Pereira da

doi:10.1590/s0100-39842007000300011

Cited by 11 publications

(3 citation statements)

References 15 publications

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“…In an in vivo study, PBM applied on rat bone before and during RT had a positive effect (181), and comparable results were described by another animal study (182). However, another in vivo study found that PBM was not able to repair the RTinduced bone damage (183).…”

Section: Bone Necrosismentioning

confidence: 56%

Photobiomodulation therapy in management of cancer therapy-induced side effects: WALT position paper 2022

et al. 2022

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DisclaimerThis article is based on recommendations from the 12th WALT Congress, Nice, October 3-6, 2018, and a follow-up review of the existing data and the clinical observations of an international multidisciplinary panel of clinicians and researchers with expertise in the area of supportive care in cancer and/or PBM clinical application and dosimetry. This article is informational in nature. As with all clinical materials, this paper should be used with a clear understanding that continued research and practice could result in new insights and recommendations. The review reflects the collective opinion and, as such, does not necessarily represent the opinion of any individual author. In no event shall the authors be liable for any decision made or action taken in reliance on the proposed protocols.ObjectiveThis position paper reviews the potential prophylactic and therapeutic effects of photobiomodulation (PBM) on side effects of cancer therapy, including chemotherapy (CT), radiation therapy (RT), and hematopoietic stem cell transplantation (HSCT).BackgroundThere is a considerable body of evidence supporting the efficacy of PBM for preventing oral mucositis (OM) in patients undergoing RT for head and neck cancer (HNC), CT, or HSCT. This could enhance patients’ quality of life, adherence to the prescribed cancer therapy, and treatment outcomes while reducing the cost of cancer care.MethodsA literature review on PBM effectiveness and dosimetry considerations for managing certain complications of cancer therapy were conducted. A systematic review was conducted when numerous randomized controlled trials were available. Results were presented and discussed at an international consensus meeting at the World Association of photobiomoduLation Therapy (WALT) meeting in 2018 that included world expert oncologists, radiation oncologists, oral oncologists, and oral medicine professionals, physicists, engineers, and oncology researchers. The potential mechanism of action of PBM and evidence of PBM efficacy through reported outcomes for individual indications were assessed.ResultsThere is a large body of evidence demonstrating the efficacy of PBM for preventing OM in certain cancer patient populations, as recently outlined by the Multinational Association for Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). Building on these, the WALT group outlines evidence and prescribed PBM treatment parameters for prophylactic and therapeutic use in supportive care for radiodermatitis, dysphagia, xerostomia, dysgeusia, trismus, mucosal and bone necrosis, lymphedema, hand-foot syndrome, alopecia, oral and dermatologic chronic graft-versus-host disease, voice/speech alterations, peripheral neuropathy, and late fibrosis amongst cancer survivors.ConclusionsThere is robust evidence for using PBM to prevent and treat a broad range of complications in cancer care. Specific clinical practice guidelines or evidence-based expert consensus recommendations are provided. These recommendations are aimed at improving the clinical utilization of PBM therapy in supportive cancer care and promoting research in this field. It is anticipated these guidelines will be revised periodically.

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Section: Bone Necrosismentioning

confidence: 56%

Photobiomodulation therapy in management of cancer therapy-induced side effects: WALT position paper 2022

et al. 2022

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“…A dose of 30Gyinduces apoptosis of osteocytes in the cortical bone, which reduces its thickness 8,12,13 , and increases the number of adipocytes in the bone marrow 13 . Doses between 45 and 90Gy reduce the periosteal apposition, i.e., outer remodeling, but they induce an opposite reaction in the endostealapposition 7 .…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, Da Cunha et al 13 found changes only in the cortical bone of non-irradiated tibiae that were similar to irradiated tibiae, but no changes in the bone marrow.…”

mentioning

confidence: 95%

Effects of ionizing radiation on bone neoformation: histometric study in Wistar rats tibiae

et al. 2011

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PURPOSE:Comparing the ionizing radiation effects on bone neoformation of rats tibiae previously submitted to radiotherapy with a single dosage of 30Gy with the contralateral tibiae that have received secondary radiation. METHODS:In thirty male Wistar rats, 30 days before surgical procedure when round defects would be created on the bone, the right tibia was irradiated with 30Gy and the left tibia received a calculated secondary radiation dose of 7Gy. Sacrifices were performed after 4, 7, 14, 21, 56 and 84 postoperative days and both tibiae were removed for histological processing. RESULTS:The left tibiae that received the dose of 7Gy has shown more bone neoformation from 14 th postoperative days, giving evidences of less damage to cellular population responsible by bone neoformation. On the other hand, the dose of 30Gyon right tibiae did not exhibit significant differences among the periods, suggesting damage of long-lasting or even permanent duration. CONCLUSION: Tibiae submitted to radiation dose of 30Gy have shown more damage to bone cells than tibiae that received secondary radiation dose of 7Gy, especially observed on 14 th , 56 th and 84 th postoperative days. Keywords: Radiation Injuries, Experimental. Bone Regeneration. Tibia. Rats. RESUMO OBJETIVO:Comparar os efeitos da radiação ionizante na reparação óssea em tíbias de ratos, submetidas à radioterapia prévia com doses 30Gy, com as tíbias contralaterais que receberam radiação secundária. MÉTODOS: No total, 30 ratos Wistar machos foram submetidos à cirurgia para realização de defeitos circulares em ambas as tíbias de cada rato, com radioterapia prévia de 30 dias, sendo que a tíbia direita recebeu a dose de 30Gy e tíbia esquerda a dose de radiação secundária calculada em 7Gy. Os sacrifícios ocorreram em 4, 7, 14, 21, 56 e 84 dias da realização do defeito ósseo e as tíbias foram removidas para processamento histológico. RESULTADOS: O grupo de 7Gy apresentou maior neoformação a partir do período de 14 dias, indicando pouco dano aos elementos celulares responsáveis pela reparação óssea, enquanto que o grupo de 30Gy não apresentou diferenças significantes entre os períodos, sugerindo um dano de efeito prolongado ou até mesmo permanente. CONCLUSÃO: As tíbias irradiadas com 30Gy apresentaram maior dano às células ósseas do que as tíbias que receberam radiação secundária de 7Gy, principalmente observadas nos períodos de 14, 56 e 84 dias. Descritores: Lesões Experimentais por Radiação. Regeneração Óssea. Tíbia. Ratos.

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