Radioterapia adjuvante no tratamento do câncer de endométrio: experiência com a associação de radio-terapia externa e braquiterapia de alta taxa de dose

Chen, Michael; Nishimoto, Inês Nobuko; Novaes, Priscila; Pellizzon, A.C.; Ferrigno, Robson; Fogaroli, R.C.; Maia, Maria Aparecida Conte; Salvajoli, João Víctor

doi:10.1590/s0100-39842005000600005

Cited by 2 publications

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“…The present study was developed in the period between March and October/2004, with 101 male and female patients > 21 years of age, affected by cancer of head and neck, chest and pelvis, with an area treated > 100 cm², in five weekly fractions at a daily radiation dose ranging between 180 cGy and 200 cGy (total dose = 4500 to 5000 cGy) (7)(8)(9) , during five weeks. High-energy X-radiation was delivered by a 6 MV Clinac 600C Varian linear accelerator, and the patients had their blood counts performed before and weekly during the treatment.…”

Section: Methodsmentioning

confidence: 99%

Avaliação semanal dos efeitos da radioterapia externa convencional pela contagem dos leucócitos e plaquetas de pacientes portadores de câncer nas áreas de cabeça e pescoço, tórax e pelve

Lundgren

Cavalcanti

Sampaio³

2008

Radiol Bras

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OBJETIVO: Avaliar a necessidade de monitoração semanal, pela contagem de leucócitos e plaquetas, dos pacientes portadores de câncer das áreas de cabeça e pescoço, tórax e pelve submetidos a radioterapia externa convencional. MATERIAIS E MÉTODOS: Cento e um adultos, portadores de câncer das áreas de cabeça e pescoço (11 pacientes), tórax (35 pacientes) e pelve (55 pacientes), submetidos a radioterapia, avaliados semanalmente com leucograma e contagem de plaquetas, comparando-se as contagens das células antes do início do tratamento com as obtidas nas semanas ao longo do tratamento, área tratada, sexo e faixa etária. RESULTADOS: A maior queda dos leucócitos e plaquetas ocorreu na quarta semana, quando linfócitos, leucócitos totais, neutrófilos, monócitos e plaquetas apresentaram diminuição de 53,5%, 26,8%, 19,4%, 22,2% e 14,6%, respectivamente, ao serem comparados aos valores do início do tratamento. Durante o tratamento, as médias geométricas da pelve foram estatisticamente menores do que as de tórax e cabeça e pescoço. Os linfócitos foram os mais sensíveis à irradiação. Não houve alteração da contagem de leucócitos e plaquetas relacionadas ao sexo ou à faixa etária. CONCLUSÃO: A partir dos resultados obtidos não parece ser necessária a contagem semanal de leucócitos e plaquetas para pacientes submetidos a radioterapia externa convencional em campos localizados.

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Section: Methodsmentioning

confidence: 99%

Avaliação semanal dos efeitos da radioterapia externa convencional pela contagem dos leucócitos e plaquetas de pacientes portadores de câncer nas áreas de cabeça e pescoço, tórax e pelve

Lundgren

Cavalcanti

Sampaio³

2008

Radiol Bras

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“…determining the better dose distribution, that is to say, the distribution which allowed the highest dose to the tumor and a minimum dose to adjacent healthy structures. With this approach, the rate of complications was considerably reduced (5)(6)(7) . Nowadays, the system fundamentals are the same, except for the incorporation of information technology to the process, in association with the utilization of highdose-rate isotopes, allowing much faster and more accurate procedures (8,9) .…”

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Algumas considerações sobre a retite actínica

Nadalin

2009

Radiol Bras

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EditorialThe article "Rectal dose assessment in patients submitted to high-dose-rate brachytherapy for uterine cervix cancer" published in the present issue of Radiologia Brasileira deals with a relevant theme currently discussed in radiotherapy and oncology.Radiation proctitis is condition of the rectum caused by ionizing radiation. It may be acute (arising during or right after radiation therapy), and in these case is generally self-limited. Symptoms of acute proctitis are diarrhea, eventual bleeding, mucus loss or constipation.Histological changes are limited to the mucosa, and the cells with a more rapid turnover are the most sensitive ones.Late radiation proctitis may occur up to two years after radiation therapy with more severe symptoms: mucus loss, pain, rectal urgency, bleeding, ulceration, stenosis and even rectovaginal fistulas. In late radiation proctitis, histological findings correspond to changes of vascular nature and fibrosis of the subintimal layer.Radiation proctitis severity is directly proportional to the dose received and dose volume, as well as to the number of fractions and the length of the interval between them. It is this dose limitation (both in radiotherapy and chemotherapy) that produces better or worst results in the management of cancer.Radiation proctitis has been known for more than one century, but factors determining a worsening in the prognosis such as association with other diseases (diabetes, hypertension, collagen diseases, etc.) have only recently been confirmed.Wherever possible, the treatment for radiation proctitis should be conservative. In the acute phase of the disease, symptomatic medication is generally enough to relieve the symptoms. The discomfort can be relieved with corticoid retention enema, besides the utilization of sulphasalazine. Major bleedings can be managed with argon laser therapy. Although criticized by some authors, the utilization of hyperbaric oxygen therapy may also be useful. Colostomy should be the last resource to be adopted, in most resistant cases (1)(2)(3)(4) .So, considering the wealth of symptoms and the difficulty in the management of radiation proctitis, this complication should be avoided at maximum, without impairing the tumor management.How to do it? Up to few years ago, brachytherapy applicators were preloaded with radioactive seeds with a known activity. The applicator was introduced and, even if the dose distribution was not the ideal, there was nothing to do but observing.Early in the 1970's, afterloading applicators were introduced. With the applicators in place, "phantom" sources were introduced, and calculations were performed for 0100-3984 © Colégio Brasileiro de Radiologia e Diagnóstico por Imagem Some considerations about radiation proctitisAlgumas considerações sobre a retite actínica

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Radioterapia adjuvante no tratamento do câncer de endométrio: experiência com a associação de radio-terapia externa e braquiterapia de alta taxa de dose

Cited by 2 publications

References 17 publications

Avaliação semanal dos efeitos da radioterapia externa convencional pela contagem dos leucócitos e plaquetas de pacientes portadores de câncer nas áreas de cabeça e pescoço, tórax e pelve

Avaliação semanal dos efeitos da radioterapia externa convencional pela contagem dos leucócitos e plaquetas de pacientes portadores de câncer nas áreas de cabeça e pescoço, tórax e pelve

Algumas considerações sobre a retite actínica

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