Gliossarcoma de tronco cerebral em paciente pediátrico: relato de caso

Moreira, Roger K.; Koppe, Daniela Cerqueira; Zignani, Juliana Machado; Marconato, Marlon Cesar; Abreu, Marcelo Rodrigues de; Pitrez, Eduardo Hennemann; Furtado, Álvaro Porto Alegre

doi:10.1590/s0100-39842004000100013

Cited by 2 publications

(4 citation statements)

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“…This component was characterized by elongated/spindle-like cells arranged in bundles, associated with necrosis, mitosis and atypia. However, components of a liposarcomatous, muscular, melanocytic or chondromatous types have also been described, although they are considerably rarer 16,24,37,38 .…”

Section: Histopathological and Immunohistochemical Findingsmentioning

confidence: 99%

Gliosarcomas: magnetic resonance imaging findings

Fukuda

Queiróz

Reis

2020

Arq. Neuro-Psiquiatr.

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Background: Central nervous system (CNS) gliosarcoma (GSM) is a rare primary neoplasm characterized by the presence of glial and sarcomatous components. Objective: In this report, we describe the clinical and neuroimaging aspects of three cases of GSM and correlate these aspects with pathological findings. We also provide a brief review of relevant literature. Methods: Three patients were evaluated with magnetic resonance imaging (MRI), and biopsies confirmed the diagnosis of primary GSM, without previous radiotherapy. Results: The analysis of conventional sequences (T1, T1 after contrast injection, T2, Fluid attenuation inversion recovery, SWI and DWI/ADC map) and advanced (proton 1H MR spectroscopy and perfusion) revealed an irregular, necrotic aspect of the lesion, peritumoral edema/infiltration and isointensity of the solid component on a T2-weighted image. These features were associated with irregular and peripheral contrast enhancement, lipid and lactate peaks, increased choline and creatine levels in proton spectroscopy, increased relative cerebral blood volume (rCBV) in perfusion, multifocality and drop metastasis in one of the cases. Conclusion: These findings are discussed in relation to the general characteristics of GSM reported in the literature.

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Section: Histopathological and Immunohistochemical Findingsmentioning

confidence: 99%

Gliosarcomas: magnetic resonance imaging findings

Fukuda

Queiróz

Reis

2020

Arq. Neuro-Psiquiatr.

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“…Magnetic resonance imaging (MRI) shows a hyperintense lesion with irregular contrast enhancement at T1. T2 sequence appears as an isointense lesion 7 . Histologically, the tumor is composed of areas of mesenchymal and glial differentiation.…”

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confidence: 99%

“…In children, the tumor may appear as an extensive cystic mass. It is important to differentiate gliosarcoma from meningioma in which there is more homogeneity with contrast enhancement and less edema 1,7 . Magnetic resonance imaging (MRI) shows a hyperintense lesion with irregular contrast enhancement at T1.…”

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confidence: 99%

“…The predominance of the sarcomatous component is associated with a better prognosis and a greater recurrence-free interval 9 . Some authors claim that metastases are rare, while others report that they occur in up to one third of cases, principally in the lungs, pleura, lymph nodes, bone marrow, liver, spinal cord, kidney and peripancreatic areas 6,7 . The role of chemo-and radiotherapy in the treatment of gliosarcoma remains to be defined, although some authors believe that these adjuvant forms of therapy are important, particularly in the case of children 1,8 .…”

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confidence: 99%

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