Insulin-like growth factor and growth hormone receptor in postpartum lactating beef cows

Schneider, Augusto; Pfeifer, Luiz Francisco Machado; Hax, Lucas Teixeira; Paludo, Giane Regina; Pino, Francisco Augusto Burkert Del; Dionello, Nelson José Laurino; Corrêa, Márcio Nunes

doi:10.1590/s0100-204x2010000800019

Cited by 6 publications

(4 citation statements)

References 32 publications

(40 reference statements)

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“…Thus, these results taken together suggest that the onset of lactation, in this study milk production, is not as much of an energetic challenge to the beef cow, and that the molecular mechanism that explains the uncoupling of the GH-IGF axis in early lactation of highproducing dairy cows is probably related to genetic selection for milk production. Similar to our results, Schneider et al (2010) did demonstrate decreased circulating IGF-I concentrations after calving in beef cows. As previously reported by this latter author, but in contrast with reports on dairy cows (Lucy, 2008;Carriquiry et al, 2009), serum IGF-I concentrations were not correlated with hepatic expression of GHR, GHR-1A or IGF1 mRNA, whereas in the present study they were correlated with the IGFBP3 to IGFBP2 mRNA ratio.…”

Section: Hepatic Expression Of Somatotropic Axis Genessupporting

confidence: 92%

Effects of herbage allowance of native grasslands in purebred and crossbred beef cows: metabolic, endocrine and hepatic gene expression profiles through the gestation–lactation cycle

Laporta

Astessiano

López-Mazz

et al. 2014

animal

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Our objective was to evaluate the metabolic, endocrine and hepatic mRNA profiles through the gestation-lactation cycle in purebred (PU: Angus and Hereford) and crossbred (CR: reciprocal F1 crosses) mutliparous beef cows (n = 32), grazing on two herbage allowances of native pastures (2.5 v. 4 kg dry matter/kg BW; LO v. HI) and their associations with cow's productive performance (calf birth weight, milk production and commencement of luteal activity). Cow BW, body condition score (BCS) and blood samples were collected monthly, starting at − 165 days relative to calving (days), and every 2 weeks after calving until +60 days of lactation. Liver biopsies were collected at − 165, − 75, − 45, − 15 ± 10, and +15 and +60 ± 3 days. Metabolic, endocrine and hepatic gene expression profiles, and calf birth weight, milk yield and postpartum commencement of luteal activity were evaluated. Overall, the most pronounced changes in metabolic, endocrine and hepatic gene expression occurred during winter gestation (−165 to − 45 days), when all cows experienced the onset of a negative energy balance (decreased BCS, glucose and insulin, and increased non-esterified fatty acid concentrations, P < 0.008). Concentrations of insulin and IGF-I were greater (P < 0.037) in HI than in LO cows. However, serum IGF-I concentrations and hepatic growth hormone receptor (GHR) and IGF1 mRNA decreased (P < 0.05) during the winter gestation period only in HI cows. Although IGF-I concentrations decreased (P < 0.05) during the early postpartum (−15 v. + 15 days) for all cows, the typical molecular mechanism that control the uncoupling of the growth hormone-IGF1 axis during the transition period of the dairy cattle (reduced hepatic GHR1A and IGF-I mRNA) was not observed in this study. The hepatic mRNA expression of key transcripts involved in gluconeogenesis and fatty-acid oxidation were upregulated (P < 0.05) during winter gestation (from − 165 to − 45, − 15 or +15 days, depending on the cow groups). Particularly, acyl-CoA oxidase-1 mRNA was greater for CR than for PU cows during winter gestation (−75 and − 45 days), and fibroblast growth factor-21 mRNA was downregulated (P < 0.01) only for HI cows during the transition (−15 v. 15 days) and lactation period (+15 to +60 days, P < 0.01). These results, together with the greater BCS, estimated energy intake, increased milk yield and shorter commencement of luteal activity in HI than in LO, and in CR than in PU cows (P < 0.018), would indicate that HI and CR cows were able to adapt more efficiently to changes in nutrient and energy supply through the gestation-lactation cycle.

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Section: Hepatic Expression Of Somatotropic Axis Genessupporting

confidence: 92%

Effects of herbage allowance of native grasslands in purebred and crossbred beef cows: metabolic, endocrine and hepatic gene expression profiles through the gestation–lactation cycle

Laporta

Astessiano

López-Mazz

et al. 2014

animal

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“…Nevertheless, in concordance with Sosa et al (2009), underfed and control pregnant ewes presented similar levels of IGF1 mRNA expression in liver. Similar findings have also been reported in ruminants in other physiological and nutritional situations (Jiang et al, 2005;Lucy et al, 2009;Schneider et al, 2010). Moreover, the mentioned reports did not find differences in GHR or GHR1A as in our study.…”

Section: Discussionsupporting

confidence: 93%

Periconceptional undernutrition modifies endocrine profiles and hepatic gene expression in sheep

Brun¹,

Meikle²,

Casal³

et al. 2014

Animal Physiology Nutrition

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This study investigated whether a 22-day period of undernutrition (half maintenance) could affect maternal endocrine responses and liver gene expression during early pregnancy (day 7). Thirty-five ewes were fed 1.5 (n = 15) or 0.5 (n = 20) their maintenance requirements and slaughtered on day 7 of the oestrus cycle or pregnancy (oestrus = day 0). Insulin, IGF, leptin and non-esterified fatty acids (NEFA) were determined on days -14, 0 and 7. Transcripts of the IGF family and adipokines receptors were determined in the liver by real-time RT-PCR. Underfed animals presented lower body weight and body condition, greater plasma concentration of NEFA, and lower plasma concentrations of leptin, insulin and IGF1 compared to adequately fed animals. Underfed ewes presented greater hepatic expression of IGFBP2 than well-fed ewes, but tended to have lesser expression of IGFBP5. While no effect of undernutrition on IGFBP4 and ADIPOR2 mRNA expressions was observed, they were increased by pregnancy in underfed animals. This study shows that undernutrition modifies endocrine profiles and hepatic gene expression of IGFBP2 and 5. The pregnancy status increased hepatic gene expression of IGFBP4 and ADIPOR2 mRNA in undernourished ewes.

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“…There was no difference in the expression of GHR between the breed and the ovulatory status. In addition, the expression of GHR was not correlated with the change of insulin-like growth factor (IGF-I) concentration postpartum in the liver [20]. FSHR has significance regarding the modulation of animal reproductive functions [10,23].…”

Section: Introductionmentioning

confidence: 99%

Expression and localisation of FSHR, GHR and LHR in different tissues and reproductive organs of female yaks

Chen¹,

Cui²,

Yu³

2018

Folia Morphol

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Insulin-like growth factor and growth hormone receptor in postpartum lactating beef cows

Abstract: -The objective of this study was to evaluate the plasma concentrations of insulin-like growth factor-I

Cited by 6 publications

References 32 publications

Effects of herbage allowance of native grasslands in purebred and crossbred beef cows: metabolic, endocrine and hepatic gene expression profiles through the gestation–lactation cycle

Effects of herbage allowance of native grasslands in purebred and crossbred beef cows: metabolic, endocrine and hepatic gene expression profiles through the gestation–lactation cycle

Periconceptional undernutrition modifies endocrine profiles and hepatic gene expression in sheep

Expression and localisation of FSHR, GHR and LHR in different tissues and reproductive organs of female yaks

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