Sequence polymorphisms in Pvs48/45 and Pvs47 gametocyte and gamete surface proteins in Plasmodium vivax isolated in Korea

Plasmodium vivax gametocyte proteins, Pvs48/45 and Pvs47, induce transmission-reducing antibodies by DNA immunization

“…In the case of Pvs47, Korea 1 of Pvs47 (Fig. 5) is reported as the dominant haplotype [43]; however, we could not detect the identical haplotype among the isolates in our study. These results are in good agreement with the results of studies on the polymorphism of Pfs48/45 [50] and Pfs47 [51]; namely, SNP alleles and haplotypes of the Pfs48/45 gene, ortholog of Pvs48/45, have a skewed geographical distribution [50].…”

“…The numbers refer to the position of amino acids in Pvs48/45 protein of Sal-1 strain. The sequence information for Korea, Indonesia and India isolates were reported by Woo et al [43], indicated by an asterisk.…”

“…Two published reports describe polymorphisms of Pvs48/45 [43,49], and one report for Pvs47 [43]. Woo et al [43] reported that Pvs48/45 of Korean vivax isolates were classified into five haplotypes (Korea 1-5 in Fig.…”

“…Woo et al [43] reported that Pvs48/45 of Korean vivax isolates were classified into five haplotypes (Korea 1-5 in Fig. 4), and the frequency of the Korea 1 haplotype of Pvs48/45 was dominant.…”

“…4) and Pvs47 (Fig. 5) were aligned with those from Sal-1 strain and published Korean, Indonesian and Indian isolates [43]. Within the 444 amino acid region determined for Pvs48/45, there were 9 polymorphic sites, all of which were dimorphic.…”