Upregulation of hsa-miR-125b in HTLV-1 asymptomatic carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis patients

Nicolete, Larissa Deadame de Figueiredo; Nicolete, Roberto; Haddad, Rodrigo; Azevedo, Rochele; Castro, Fabíola Attié de; Tanaka, Yuetsu; Takayanagui, Osvaldo Massaiti; Covas, Dimas Tadeu; Kashima, Simone

doi:10.1590/s0074-02762012000600020

Cited by 4 publications

(1 citation statement)

References 19 publications

(12 reference statements)

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“…We demonstrated that miR-125b expression is increased in normal cervix infected with HPV, while the relative expression seems to decrease as lesions progress ( Table 2 ). According to literature, an increased expression of miR-125b shortly after HPV infection can be explained by interaction with viral proteins [ 23 , 24 ]. Based on a recent study that revealed strong homology between miR-125b and the HPV-L2, an increased expression of miR-125b is a quick response to HPV productive infection shortly after viral infection.…”

Section: Discussionmentioning

confidence: 99%

miR-34a and miR-125b Expression in HPV Infection and Cervical Cancer Development

Ribeiro

Marinho‐Dias

Monteiro

et al. 2015

BioMed Research International

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We aimed to characterize miR-125b and miR-34a expression in 114 women with different cervical lesions: normal epithelium with (n = 20) and without (n = 29) HPV infection; LSIL (n = 28); HSIL (n = 29); and ICC (n = 8). miRNA expression analysis was performed by comparing the distinct groups with the reference group (women with normal epithelium without HPV). For miR-125b, we observed a twofold (2−ΔΔCt = 2.11; P = 0.038) increased expression among women with normal epithelium with HPV infection and a trend of downregulation in different cervical lesions including an 80% reduction (2−ΔΔCt = 0.21; P = 0.004) in ICC. Similarly, miR-34a expression analysis revealed an increased expression (2−ΔΔCt = 1.69; P = 0.049) among women with normal cervix and HPV infection, and despite no significant correlation with cervical lesions, its expression was increased by twofold (2−ΔΔCt = 2.08; P = 0.042) in ICC. Moreover, miR-125b levels were able to predict invasive cancers with 88% sensitivity and 69% specificity. Results showed that while miR-34a expression seems to be correlated with invasive cervical cancer, miR-125b expression is significantly changed within the different cervical lesions and their levels should be further investigated as possible predictive/prognostic biomarkers using a noninvasive approach.

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Section: Discussionmentioning

confidence: 99%

miR-34a and miR-125b Expression in HPV Infection and Cervical Cancer Development

Ribeiro

Marinho‐Dias

Monteiro

et al. 2015

BioMed Research International

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MicroRNAs as biomarkers of cervical cancer development: a literature review on miR-125b and miR-34a

Ribeiro

Sousa

2014

Mol Biol Rep

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MicroRNAs are non-coding RNAs with important functions in several biological processes, such as, regulation of cell cycle, immune response, inflammation, and apoptosis. In fact, deregulation and abnormal expression of these molecules is associated with human pathologies including cancer and several have already emerged as potential prognostic biomarkers in different neoplasias. miR-34a is directly regulated by p53 and acts as tumor suppressor while miR-125b plays a significant role in immune response and apoptosis. In cervical carcinogenesis, HPV proteins seem to interact with both miR-34a and miR-125b changing its expression and promoting persistent infection and cervical cancer development. In this review we describe the potential role of miR-125b and miR-34a in cervical carcinogenesis, including interaction with HPV and mechanism of deregulation. Additionally, their clinical applications in cervical cancer as prognostic/predictive biomarkers are also briefly discussed.

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The Utility of Circulating microRNAs as Biomarkers in Viral Infection-Associated Cancers

Journal

Adamson-Small

2014

PDJ

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Since their discovery, the role of microRNAs (miRNAs) has been expanding. These small, non-coding RNAs have been associated with gene regulation by binding to 3' UTRs. Specific miRNA expression profiles are associated with cancer development and may serve as markers of malignancy. Many of these cancers are also associated with viral infections. As some viruses express their own miRNAs, research has begun to investigate if cellular or viralencoded miRNAs could also serve as specific markers of these virus-associated cancers. Discovery of miRNAs in both tissues and serum have been reported in patients with virus positive tumors. These miRNAs may emerge as important, non-invasive diagnostic tools for detecting tumor development and progression and improving cancer treatment.

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Upregulation of hsa-miR-125b in HTLV-1 asymptomatic carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis patients

Cited by 4 publications

References 19 publications

miR-34a and miR-125b Expression in HPV Infection and Cervical Cancer Development

miR-34a and miR-125b Expression in HPV Infection and Cervical Cancer Development

MicroRNAs as biomarkers of cervical cancer development: a literature review on miR-125b and miR-34a

The Utility of Circulating microRNAs as Biomarkers in Viral Infection-Associated Cancers

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