The high prevalence of Torque teno virus DNA in blood donors and haemodialysis patients in southern Brazil

Massaú, Aline; Martins, Cristiana Alves; Nachtigal, Gilca; Araújo, Anelise Bergmann; Rossetti, Maria Lúcia Rosa; Niel, Christian; Silva, Cláudia Maria Dornelles da

doi:10.1590/s0074-02762012000500017

Cited by 16 publications

(14 citation statements)

References 21 publications

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“…Generally, the prevalence of TTV among HD patients ranges from 27.8% to 68.8% (Afkari et al, 2012;Irshad et al, 2010;Massaú et al, 2012;Rivanera et al, 2009), and in the present work, the frequency of TTV among HD patients was 28% ( Table 2). The wide variation in the prevalence rates of TTV may be related to the increasing number of TTV-infected cases over time, the medications used, or the suboptimal TTV titer of the test samples.…”

Section: Discussionsupporting

confidence: 59%

Surveillance and impact of occult hepatitis B virus, SEN virus, and torque teno virus in Egyptian hemodialysis patients with chronic hepatitis C virus infection

Amer

Yousif

Mohtady

et al. 2020

International Journal of Infectious Diseases

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Egypt ranks first regarding the prevalence of hepatitis C virus (HCV) infection. Many patients have concomitant diseases like kidney disorders requiring hemodialysis, a procedure carrying the hazard of transmitting other hepatitis viruses. The purpose of this study was to investigate for occult hepatitis B virus (HBV), SEN virus (SENV), and torque teno virus (TTV) among chronic HCV patients on maintenance hemodialysis to identify their impacts. Methods: A total of 325 hemodialysis patients were enrolled and divided into two groups based on HCV RNA testing results. Blood samples were collected before hemodialysis. Sera were tested for hepatitis B core antibodies (anti-HBc) and hepatitis B surface antibodies (anti-HBs) using ELISA. HBV, SENV, and TTV DNA were detected by PCR. The serum alanine aminotransferase (ALT) level was measured. Results: Anti-HBc and HBV DNA were detected in 73.1% and 50.8% of group 1 versus 36.4% and 22.6% of group 2. The serum ALT level was higher in group 1 than group 2. SENV was detected in 11.5% of group 1 versus 8.2% of group 2. TTV was detected in 29% of group 1 versus 27% of group 2. Conclusions: There is an increased prevalence of occult HBV in our locality among chronic HCV patients undergoing hemodialysis. The existence of SENV and TTV viremia has no clinical impact.

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Section: Discussionsupporting

confidence: 59%

Surveillance and impact of occult hepatitis B virus, SEN virus, and torque teno virus in Egyptian hemodialysis patients with chronic hepatitis C virus infection

Amer

Yousif

Mohtady

et al. 2020

International Journal of Infectious Diseases

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“…The nucleotide sequence variation between genotypes of a single species (TTV) can be greater than 50% and distributed among at least 39 genotypes . The reported TTV prevalence in blood donors varies, possibly due to the use of different PCR primers used for detection, from a few percent to 100% . Humans may at any one time be viremic with multiple genotypes of TTV, TTV midi virus, and Torque teno mini virus …”

Section: Discussionmentioning

confidence: 99%

“…38,39 The reported TTV prevalence in blood donors varies, possibly due to the use of different PCR primers used for detection, from a few percent to 100%. 40,41 Humans may at any one time be viremic with multiple genotypes of TTV, TTV midi virus, and Torque teno mini virus. 42 GBV-C, originally known as hepatitis G virus, and recently renamed HPgV, 7 is a single-stranded RNA virus belonging to the Pegivirus genus within the family Flaviviridae, consisting of several genotypes with distinct geographic distributions.…”

Section: Discussionmentioning

confidence: 99%

Viral nucleic acids in human plasma pools

Zhang

Deng

et al. 2016

Transfusion

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“…Other studies in Brazilian populations showed 60% prevalence in Belém, Pará 20 and 50.5% in the southeastern region of the state of São Paulo. 18 In southern Brazil, studies showed a high prevalence of the virus in healthy donors (73.3%) in the municipality of Pelotas, RS 21 and also the presence of the virus in samples of drinking water and sewage water. 13 , 22 …”

Section: Discussionmentioning

confidence: 99%

Prevalence of Torque teno virus in healthy donors of Paraná State, southern Brazil

Mazzola

Saito

Yamakawa

et al. 2015

Revista Brasileira de Hematologia e Hemoterapia

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ObjectiveTo determine the prevalence of the Torque teno virus in healthy donors in the northern and northwestern regions of the state of Paraná, southern Brazil.MethodsThe Torque teno virus was detected by a nested polymerase chain reaction using a set of oligoprimers for the N22 region.ResultsThe prevalence of the virus was 69% in 551 healthy blood donors in southern Brazil. There was no statistically significant difference between the presence of the virus and the variables gender, ethnicity and marital status. There was significant difference in the prevalence of the virus regarding the age of the donors (p-value = 0.024) with a higher incidence (74.7%) in 18- to 24-year-old donors.ConclusionA high prevalence of Torque teno virus was observed in the population studied. Further studies are needed to elucidate the routes of contamination and the clinical implications of the virus in the healthy population.

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The high prevalence of Torque teno virus DNA in blood donors and haemodialysis patients in southern Brazil

Cited by 16 publications

References 21 publications

Surveillance and impact of occult hepatitis B virus, SEN virus, and torque teno virus in Egyptian hemodialysis patients with chronic hepatitis C virus infection

Surveillance and impact of occult hepatitis B virus, SEN virus, and torque teno virus in Egyptian hemodialysis patients with chronic hepatitis C virus infection

Viral nucleic acids in human plasma pools

Prevalence of Torque teno virus in healthy donors of Paraná State, southern Brazil

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