Persistence of experimental Rocio virus infection in the golden hamster (Mesocricetus auratus)

Henriques, Daniele Freitas; Quaresma, Juarez Antônio Simões; Fuzii, Helen Thais; Nunes, Márcio Roberto Teixeira; Silva, Eliana Vieira Pinto da; Carvalho, Valéria Lima; Martins, Lívia Carício; Casseb, Samir Mansour Moraes; Chiang, Jannifer Oliveira; Vasconcelos, Pedro Fernando da Costa

doi:10.1590/s0074-02762012000500009

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…Of the mosquito-borne flaviviruses, Japanese encephalitis virus, WNV, SLEV, and more recently, Rocio virus are examples of viruses that have been shown to persist in multiple vertebrate animals, including the development of viruria. 7,8,15,16 Of the tick-associated flaviviruses, tick-borne encephalitis virus, Kyasanur forest disease virus, and Omsk hemorrhagic fever virus are some examples of viruses that persist in tissues after infection. [17][18][19] However, only Omsk hemorrhagic fever virus has been shown to cause chronic renal infection and viruria in muskrats.…”

Section: Discussionmentioning

confidence: 99%

Pathogenesis of Modoc Virus (Flaviviridae; Flavivirus) in Persistently Infected Hamsters

Adams

Rosa

Nunes

et al. 2013

The American Journal of Tropical Medicine and Hygiene

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Abstract. The long-term persistence of Modoc virus (MODV) infection was investigated in a hamster model. Golden hamsters (Mesocricetus auratus) were infected by subcutaneous inoculation with MODV, in which fatal encephalitis developed in 12.5% (2 of 16). Surviving hamsters shed infectious MODV in their urine during the first five months after infection, and infectious MODV was recovered by co-cultivation of kidney tissue up to eight months after infection. There were no histopathologic changes observed in the kidneys despite detection of viral antigen for 250 days after infection. Mild inflammation and neuronal degeneration in the central nervous system were the primary lesions observed during early infection. These findings confirm previous reports of persistent flavivirus infection in animals and suggest a mechanism for the maintenance of MODV in nature.

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Section: Discussionmentioning

confidence: 99%

Pathogenesis of Modoc Virus (Flaviviridae; Flavivirus) in Persistently Infected Hamsters

Adams

Rosa

Nunes

et al. 2013

The American Journal of Tropical Medicine and Hygiene

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“…Histopathological changes and expression of viral antigens were observed in liver, kidney, lung and brain up to 4 months after infection. These findings show that ROCV is able to cause persistent infection in golden hamsters after intraperitoneal inoculation [25].…”

Section: Rocio Virus (Rocv)mentioning

confidence: 54%

Review on Infections of the Central Nervous System by St. Louis Encephalitis, Rocio and West Nile Flaviviruses in Brazil, 2004-2014

Figueiredo¹,

Figueiredo²

2014

AiM

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Rocio (ROCV), Saint Louis encephalitis (SLEV) and West Nile (WNV) are Flavivirus (Flaviviridae) probably carried by birds and transmitted by Culex mosquitoes. We show here a review on infections of the central nervous system by St. Louis Encephalitis, Rocio and West Nile Flaviviruses in Brazil, 2004-2014. In the last 10 years, serologic surveys in horses showed high proportions of seropositive animals which point out that SLEV and ROCV have circulated infecting horses in westcentral, southeast and other regions of Brazil and that WNV has been introduced into Brazil and circulates mostly in Pantanal region. However humans infected by WNV have not been reported. In the State of São Paulo: SLEV was isolated from a case clinically diagnosed as dengue in 2004; in 2006, 6 SLEV patients including 3 cases of menigoencephalitis were reported in the middle of a large epidemic of dengue type 3; and in 2008, 1 patient with acute febrile illness that was IgMpositive for dengue was found infected by SLEV by detection of the virus genome. In 2010, ROCV genome was detected in the cerebrospinal fluids of 2 patients from the northern region with meningoenchephalitis and also AIDS. This was the first report of infections by ROCV in the last 34 years and curiously, it occured more than 2000 km from where the virus was firstly found. It is necessary to improve the surveillance of SLEV, ROCV and WNV in Brazil.

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“…24 A chronic persistence infection was also observed after intraperitoneal infection of ROCV into golden hamsters in which virus replicated and was excreted continuously. 25 Recently, our group showed that severe encephalitis developed in BALB/C mice infected with ROCV and these mice had inflammatory cell infiltrates in the CNS, 21 which suggested that infection of the CNS recruits leukocytes, and that this recruitment generates tissue damage in an attempt to control infection.…”

Section: Discussionmentioning

confidence: 99%

Influence of the CCR-5/MIP-1 α Axis in the Pathogenesis of Rocio Virus Encephalitis in a Mouse Model

Chávez¹,

Franca²,

Oliveira³

et al. 2013

The American Journal of Tropical Medicine and Hygiene

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Abstract. Rocio virus (ROCV) caused an outbreak of human encephalitis during the 1970s in Brazil and its immunopathogenesis remains poorly understood. CC-chemokine receptor 5 (CCR5) is a chemokine receptor that binds to macrophage inflammatory protein (MIP-1 α). Both molecules are associated with inflammatory cells migration during infections. In this study, we demonstrated the importance of the CCR5 and MIP-1 α, in the outcome of viral encephalitis of ROCV-infected mice. CCR5 and MIP-1 α knockout mice survived longer than wild-type (WT) ROCV-infected animals. In addition, knockout mice had reduced inflammation in the brain. Assessment of brain viral load showed mice virus detection five days post-infection in wild-type and CCR5−/− mice, while MIP-1 α−/− mice had lower viral loads seven days postinfection. Knockout mice required a higher lethal dose than wild-type mice as well. The CCR5/MIP-1 α axis may contribute to migration of infected cells to the brain and consequently affect the pathogenesis during ROCV infection.

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Persistence of experimental Rocio virus infection in the golden hamster (Mesocricetus auratus)

Cited by 6 publications

References 15 publications

Pathogenesis of Modoc Virus (Flaviviridae; Flavivirus) in Persistently Infected Hamsters

Pathogenesis of Modoc Virus (Flaviviridae; Flavivirus) in Persistently Infected Hamsters

Review on Infections of the Central Nervous System by St. Louis Encephalitis, Rocio and West Nile Flaviviruses in Brazil, 2004-2014

Influence of the CCR-5/MIP-1 α Axis in the Pathogenesis of Rocio Virus Encephalitis in a Mouse Model

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