Detection of the first incidence of Akodon paranaensis naturally infected with the Jabora virus strain (Hantavirus) in Brazil

Oliveira, Renata Carvalho de; Guterres, Alexandro; Schrago, Carlos G.; Fernandes, Jorlan; Teixeira, Bernardo Rodrigues; Zeccer, Suzana; Bonvicino, Cibele Rodrigues; D’Andrea, Paulo Sérgio; Lemos, Elba Regina Sampaio de

doi:10.1590/s0074-02762012000300020

Cited by 14 publications

(13 citation statements)

References 21 publications

(17 reference statements)

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“…Moreover, the spillover A. paranaensis/JABV was also reported in another area of the Mixed Ombrophilous Forest 39 emphasizing the importance of this species in maintaining JABV. As in JUQV-like, JABV spillover infections seem to be important during periods of low viral prevalence in the primary host, because all spillover infections occurred in months of low A. montensis infection.…”

Section: Discussionmentioning

confidence: 66%

“…The rodent samples were analyzed using the polymerase chain reaction with reverse transcription (750 base pair [bp]) and nested reactions (478 bp) of the S segment, with primers AG04-25F (5 TAGTAGACTCCTTGAKAAGCT 3 ), AG733-752R (5 GAYTGGATGGAAAGGATWGA 3 ), and AG274-291F (5 CCCTGTTGGATCAACTGG 3 ). 39,67 For purification we adopted WizardSV Gel and the PCR Clean-Up System kit (Promega, Corp., Madison, WI) and for sequencing the BiqDye Terminator v3.1 Cycle Sequencing Kit (Applied Biosystems, Grand Island, NY). Virus sequences were analyzed with MEGA5 software, and hantavirus genotypes were identified with BLAST (http://blast.ncbi.nlm.nih.gov) through comparison with other hantavirus sequences.…”

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confidence: 99%

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Population Ecology of Hantavirus Rodent Hosts in Southern Brazil

Teixeira¹,

Loureiro²,

Strecht³

et al. 2014

The American Journal of Tropical Medicine and Hygiene

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Abstract.In this study we analyze population dynamics of hantavirus rodent hosts and prevalence of infection over a 2-year period in Southern Brazil, a region with a high incidence of hantavirus pulmonary syndrome. The 14 small mammal species captured were composed of 10 rodents and four marsupials, the six most abundant species being Akodon serrensis, Oxymycterus judex, Akodon montensis, Akodon paranaensis, Oligoryzomys nigripes, and Thaptomys nigrita. These species displayed a similar pattern with increasing population sizes in fall/winter caused by recruitment and both, increase in reproductive activity and higher hantavirus prevalence in spring/summer. Specific associations between A. montensis/ Jaborá Virus (JABV) and O. nigripes/Juquitiba-like Virus (JUQV-like) and spillover infections between A. paranaensis/ JABV, A. serrensis/JABV, and A. paranaensis/JUQV-like were observed. Spillover infection in secondary hosts seems to play an important role in maintaining JABV and JUQV-like in the hantavirus sylvatic cycle mainly during periods of low prevalence in primary hosts.

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Section: Discussionmentioning

confidence: 66%

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confidence: 99%

Population Ecology of Hantavirus Rodent Hosts in Southern Brazil

Teixeira¹,

Loureiro²,

Strecht³

et al. 2014

The American Journal of Tropical Medicine and Hygiene

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“…The high diversity of these rodents, coupled with a recent distribution pattern that began in the northern Andes (Colombia and Venezuela), and later inhabited the more southern regions of South America [27,28,29]. The occurrence of virus adaptation and host switching appears to be more frequent in the Midwest and Southern regions of Brazil, extending to Paraguay, Uruguay and Argentina [8,16,30]. Additionally, considering that the hantavirus are RNA virus and are very recent according to Ramsden [31], this high diversity and recent radiation of the rodents in South America make these events (host switching and adaptation) more common than previously believed.…”

Section: Resultsmentioning

confidence: 99%

“…An increased number of eco-epidemiological studies have been conducted in different Brazilian regions and nine different hantavirus genotypes have been identified so far; some of them have been found to naturally infect more than one species of rodent. Cross-species transmission events at the genus and species levels has been suggested between South American rodents species, as reported for Juquitiba (JUQ) and Jabora (JAB), pathogenic and non pathogenic viruses, respectively [6,7,8,9]. We report here the JUQ virus in Oligoryzomys fornesi, the presumed reservoir for Anajatuba (ANAJ) virus in Brazilian Amazon, captured in Mato Grosso do Sul State, Cerrado Biome (Midwestern) [10].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Juquitiba Virus in Oligoryzomys fornesi from Brazilian Cerrado

Guterres

Oliveira

Fernandes

et al. 2014

Viruses

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The Juquitiba virus, an agent of Hantavirus Cardiopulmonary Syndrome, is one of the most widely distributed hantavirus found in South America. It has been detected in Oligoryzomys nigripes, Akodon montensis, Oxymycterus judex, Akodon paranaensis in Brazil and in O. nigripes, Oryzomys sp. and Oligoryzomys fornesi rodents in Argentine, Paraguay and Uruguay. Here, we report the genomic characterization of the complete S segment from the Juquitiba strain, isolated from the lung tissues of O. fornesi, the presumed rodent reservoir of Anajatuba virus in Brazilian Amazon, captured in the Cerrado Biome, Brazil.

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“…Other described variants were related only to rodents: Jabora, Rio Mamore and Rio Mearim variants ( Figure 1) [23,24].…”

Section: Types Of Hantavirus In Brazil and Their Epidemiological Detementioning

confidence: 99%

Twenty years of hantavirus pulmonary syndrome in Brazil: a review of epidemiological and clinical aspects

Pinto

Hamidad

Filho

et al. 2014

J Infect Dev Ctries

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Hantavirus infection is transmitted to humans by wild rodents and the most common clinical form in Brazil is the Hantavirus Pulmonary Syndrome (HPS). The first serological evidence of the disease was identified in 1990, in Recife, Pernambuco State, and later in 1993 in Juquitiba, State of São Paulo. Since then there has been a progressive increase in case notification in all regions of the country. The clinical aspects of the disease in Brazil are characterized by a prodromal phase, with nonspecific signs and symptoms of an acute febrile illness. After about three days, respiratory distress develops, accompanied by dry cough that turns progressively productive, evolving to dyspnea and respiratory failure with cardiogenic shock. Although the majority of patients receive hospital care in intensive care therapy units, case-fatality rate in Brazil ranges from 33% to 100% depending on the region. Besides it has to be added the problem of differential diagnosis with other prevalent diseases in the country, like dengue and leptospirosis. Questions about the impact of uncontrolled urbanization and other environmental changes caused by human action have been raised. Due to increasing incidence and high case-fatality, there is an urge to respond to such questions to recommend preventative measures. This article aims to review the main acquisitions in clinical and epidemiological knowledge about HPS in Brazil in the last twenty years.

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Detection of the first incidence of Akodon paranaensis naturally infected with the Jabora virus strain (Hantavirus) in Brazil

Cited by 14 publications

References 21 publications

Population Ecology of Hantavirus Rodent Hosts in Southern Brazil

Population Ecology of Hantavirus Rodent Hosts in Southern Brazil

Characterization of Juquitiba Virus in Oligoryzomys fornesi from Brazilian Cerrado

Twenty years of hantavirus pulmonary syndrome in Brazil: a review of epidemiological and clinical aspects

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