“…For instance, it has been conclusively shown that PTMs, especially acetylations and methylations, and the propagation of heterochromatin away from the telomeres control the transcriptional switching between VAR genes that will trigger antigenic variation and enable immune evasion by the parasite, Plasmodium falciparum (Freitas-Junior et al, 2005; Chookajorn et al, 2007; Malmquist et al, 2012; Jiang et al, 2013). In Schistosoma mansoni , N-ChIP-seq experiments have been successfully performed to compare chromatin structure at different stages of the parasite life cycle, on different strains and on different sexes (Caby and Pierce, 2009; Cosseau et al, 2009; Lepesant et al, 2011, 2012). These advances in understanding S. mansoni epigenetic regulation have lead to the identification of promising new targets for the development of new drug to combat schistosomiasis (Pierce et al, 2012; Lancelot et al, 2013; Marek et al, 2013).…”