Genetic polymorphism in Taenia solium metacestodes from different Brazilian geographic areas

Genetic variation in the Cytbgene of human cerebral Taenia soliumcysticerci recovered from clinically and radiologically heterogeneous patients with neurocysticercosis

“…This finding highlights the genetic heterogeneity among cysticerci isolated from human patients. These genetic variations are consistent with the genetic heterogeneity observed among swine-derived T. solium metacestodes isolated from different areas of Mexico and other endemic countries ( Maravilla et al 2003 , 2008 , Vega et al 2003 , Bobes et al 2010 , Barcelos et al 2012 ).…”

“…In the case of T. solium cysticercosis, genetic variation of the parasite has reportedly been associated with different parasite antibody recognition patterns ( Barcelos et al 2012). …”

Serodiagnosis of human neurocysticercosis using antigenic components of Taenia solium metacestodes derived from the unbound fraction from jacalin affinity chromatography

“…Group 1 was composed of 40 patients who had been diagnosed with definitive NCC based on the presence of clinical symptoms, epidemiological data, positive immunological tests and evidence of the parasite by computerised tomography, as follows: (i) clinical syndrome: all patients presented at least one type of clinical manifestation that was suggestive of NCC, including epilepsy (55%), cephalea (50%), dizziness (27.5%), dementia (12.5%), faintness (10%) and hydrocephalus (2.5%) and no signs or symptoms that were suggestive of the presence of metacestodes in other organs were present; (ii) epidemiological data: all patients came from or lived in an area where cysticercosis is endemic, as previously described (Barcelos et al 2012), in addition to at least two instances of household contact with T. solium infection; (iii) immunological diagnosis: cerebrospinal fluid samples were positive for anti-cysticercal IgG antibodies by ELISA; (iv) cerebral computerised tomographic findings: all patients presented evidence of the parasite by neuroimaging with the following classifications based on Sotelo et al 1985: eight (20%) vesicular, 15 (37.5%) vesicular/ calcified and 17 (42.5%) calcified metacestodes. According to the Del Brutto diagnostic criteria, all patients from Group 1 had a definitive diagnosis; 29 (72.5%) had the absolute criteria and 11 (27.5%) presented two major plus one minor or epidemiologic criteria (Del Brutto 2012).…”

Pork as a source of human parasitic infection

“…A relationship between genetic polymorphisms among Ta. solium metacestodes and differences in antibody detection in patients with neurocysticercosis has been established .…”