Report of Lutzomyia longipalpis (Lutz &amp; Neiva, 1912) (Diptera: Psychodidae: Phlebotominae) in a cutaneous-leishmaniasis-endemic area of Panama

Valderrama, Anayansí; Tavares, Mara Garcia; Filho, José Dilermando Andrade

doi:10.1590/s0074-02762011000800025

Cited by 8 publications

(6 citation statements)

References 15 publications

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“…The urban emergence is reported as: (i) "first" AVL autochthonous urban or atypical cases ( Duarte et al 1994 , Noyes et al 1997 , Carrillo et al 1999 , de Lima et al 2009 , de Campos et al 2013 , Silva et al 2014a, Von Zuben et al 2014 ), (ii) urban outbreaks ( Aguilar et al 1998 , Delgado et al 1998 , Feliciangeli et al 1999 , Bevilacqua et al 2001 , Zerpa et al 2002 , Flórez et al 2006 , de Oliveria et al 2006, Mestre & Fontes 2007 , Salomón et al 2008 , Barata et al 2013) , (iii) the finding of Lu. longipalpis in urban environments or areas without previous records ( Paula et al 2008 , Souza & Borges 2008 , Andrade Filho & Brazil 2009, Souza et al 2009 , Salomón et al 2011a, b, Valderrama et al 2011 , Brazil et al 2012 , Santos et al 2012 , Acosta et al 2013 , Bravo et al 2013) and (iv) predicted changes of distribution or altitudinal shifts ( González et al 2014) . On the other hand, the literature recorded the spread of the vector and infected reservoirs/hosts by L. infantum in urban environments from the Northwest to the Southeast of Brazil ( Maia-Elkhoury et al.…”

Section: The Urbanisation-dispersion Of Lu Longipalpismentioning

confidence: 97%

Lutzomyia longipalpis urbanisation and control

Salomón

Feliciangeli

Quintana

et al. 2015

Mem. Inst. Oswaldo Cruz

107

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Since the description of Lutzomyia longipalpis by Lutz and Neiva more than 100 years ago, much has been written in the scientific literature about this phlebotomine species. Soares and Turco (2003) and Lainson and Rangel (2005) have written extensive reviews focused on vector-host-parasite interactions and American visceral leishmaniasis ecology. However, during the last two decades, the success of Lu. longipalpis in colonising urban environments and its simultaneous geographical spreading have led to new theoretical and operational questions. Therefore, this review updates the general information about this species and notes the more challenging topics regarding the new scenario of urbanisation-spreading and its control in America. Here, we summarise the literature on these issues and the remaining unsolved questions, which pose recommendations for operational research.

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Section: The Urbanisation-dispersion Of Lu Longipalpismentioning

confidence: 97%

Lutzomyia longipalpis urbanisation and control

Salomón

Feliciangeli

Quintana

et al. 2015

Mem. Inst. Oswaldo Cruz

107

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“…Another study carried out in a community of Panama in which the environment has undergone urbanization, presenting areas degraded by deforestation, Lu. longipalpis was also reported in an area endemic for CL 16 . Other studies have also mentioned rodents 12 and dogs 17 naturally infected by L. (L.) amazonensis in endemic areas for VL in Brazil. In conclusion, our data demonstrated the competence of Lu.…”

Section: Discussionmentioning

confidence: 72%

“…These facts have generated the hypothesis that Lu. longipalpis may be infected and be able to transmit L. (L.) amazonensis, mainly in areas where its natural vectors are rare [12][13][14][15][16][17] .…”

Section: Introductionmentioning

confidence: 99%

Experimental transmission of Leishmania (Leishmania) amazonensis to immunosuppressed mice through the bite of Lutzomyia longipalpis (Diptera: Psychodidae) results in cutaneous leishmaniasis

Silva

Cruz

Coutinho

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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Lutzomyia longipalpis is the natural vector of Leishmania (Leishmania) infantum, but it is also permissive for several Leishmania species that are related to cutaneous leishmaniasis (CL). Maranhao State (Northeast of Brazil) is endemic for CL and has the highest number of cases of diffuse cutaneous leishmaniasis (DCL) in the country. It is a rare disease associated with a defective immune response mainly caused by L. (L.) amazonensis. Additionally, the number of immunosuppressed patients infected with the etiologic agents of CL has increased, including regions in which the main vectors of CL are rare. Therefore, we investigated whether Lu. longipalpis is able to transmit L. (L.) amazonensis to uninfected and immunosuppressed mice, resulting in CL. For that, 291 sand flies took an initial blood meal in mice infected with L. (L.) amazonensis. Of these, 17 underwent a second feeding on uninfected and immunosuppressed mice (of which 58.8% were also positive for Leishmania according to data on the dissection of the intestine). After 27 days of infection, these mice exhibited leishmaniotic lesions. The occurrence of parasites on the animal's skin was confirmed by limiting dilution and immunohistopathological analyses. Parasite DNA was also detected in paw lesions and inguinal lymph nodes. DNA sequencing confirmed the Leishmania species in insects and mice. The results confirmed the ability of Lu. longipalpis to become infected and experimentally transmit L. (L.) amazonensis to immunosuppressed rodents, resulting in leishmaniotic lesions. Our data open perspectives for the potential role of Lu. longipalpis in the epidemiology of urban cutaneous leishmaniasis, especially in immunosuppressed patients.

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“…longipalpis, que tiene la capacidad vectorial y valga decir desde hace mucho tiempo. [33] Darién es una provincia pluriétnica y multicultural ubicada a escasos 223 kms. de la capital de Panamá, que alberga nueve (9) grupos indígenas autóctonos, afrodescendien tes y mestizos y es la región fronteriza con Colombia, con la que comparte el famoso Tapón del Darién.…”

Section: Resultados Materiales Y Métodos Discusiónunclassified

Leishmaniasis: desafío para la salud publica en la región del Darién. [Leishmaniasis challenge for public health in the Darien region]

Cumbrera

Gonzalez²

2021

Rev Med Panama

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La leishmaniasis es un conjunto de enfermedades zoonóticas trasmitida a los humanos por la picadura de insectos hematófagos del género Lutzomyia. Su eco-epidemiología es compleja y los patrones de variación de su incidencia, en tendencia creciente, contradicen las propuestas anteriores de que el desarrollo socioeconómico y la urbanización eliminaría la enfermedad. Por el contrario, la vulnerabilidad de la población se ha visto afectada por los cambios demográficos y factores antropogénicos que, a su vez, transforman la dinámica y el flujo genético poblacional de los vectores y reservorios, modificando sus ciclos de transmisión. Por sus elevados números de casos y su progresiva expansión geográfica, la leishmaniasis es considerada por la Organización Mundial de la Salud (OMS) una enfermedad parasitaria de carácter emergente o reemergente de alto impacto. Las incapacidades que genera esta enfermedad por mutilaciones y deformaciones no solo se traducen en pérdida de horas de productividad, sino también tienen el impacto incapacitante de la pérdida de salud y bienestar en la población que, en la mayoría de los casos, son desestimados por el desconocimiento del comportamiento epidemiológico que presenta. En este artículo se propone una reflexión sobre los factores que inciden en el ciclo de transmisión de las Leishmania spp, y el impacto que las misma pueda tener en la región del Darién, con lo cual pretendemos intentar dilucidar aspectos para la actualización de la información para Panamá y subrayar la importancia de la reflexión teórica ante cualquier tipo de intervención práctica relacionada con este tema.ABSTRACTLeishmaniasis is a group of zoonotic diseases transmitted to humans by the bite of blood-sucking insects of the genus Lutzomyia. It has a complex eco-epidemiology and the patterns of variation of its incidence in increasing trend, contradict the previous proposals that socioeconomic development and urbanization would eliminate the disease. Contrary sensu, the vulnerability of the population has been affected by demographic changes and anthropogenic factors that, in turn, transform the dynamics and population gene flow of vectors and reservoirs, modifying their transmission cycles. Due to a high number of cases and its progressive geographical expansion, leishmaniasis is considered by World Health Organization (WHO) to be an emerging or re-emerging parasitic disease with a high impact. The disabilities generated by this disease due to mutilations and deformations translate into lost hours of productivity, but, the disabling impact of the loss of health and well-being in the population, in most cases, are dismissed due to ignorance of epidemiological behavior. This article proposes a reflection on the factors that affect the transmission cycle of Leishmania spp, and the impact that they may have in the Darien region, with which we intend to try to elucidate aspects for updating information for Panama and underline the importance of theoretical reflection before any type of practical intervention related to this topic.

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Report of Lutzomyia longipalpis (Lutz & Neiva, 1912) (Diptera: Psychodidae: Phlebotominae) in a cutaneous-leishmaniasis-endemic area of Panama

Cited by 8 publications

References 15 publications

Lutzomyia longipalpis urbanisation and control

Lutzomyia longipalpis urbanisation and control

Experimental transmission of Leishmania (Leishmania) amazonensis to immunosuppressed mice through the bite of Lutzomyia longipalpis (Diptera: Psychodidae) results in cutaneous leishmaniasis

Leishmaniasis: desafío para la salud publica en la región del Darién. [Leishmaniasis challenge for public health in the Darien region]

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