Monitoring the circulation of rotavirus among children after the introduction of the RotarixTM vaccine in Goiânia, Brazil

Borges, Ana Maria Tavares; Souza, Menira; Fiaccadori, Fabíola Souza; Cardoso, Divina das Dôres de Paula

doi:10.1590/s0074-02762011000400018

Cited by 14 publications

(6 citation statements)

References 25 publications

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“…One of the particularities of this study was the occurrence of rotavirus in 2.5% of the stool samples without diarrhea, contrary to the findings of Borges et al (2011) [21] that found no rotavirus among non-diarrhea stool samples. This finding suggests that the attenuating effect of the vaccine may be responsible for the subsequent asymptomatic infections, which is similar to original data from Mexico, where the natural rotavirus infection was partially protective against subsequent infection [22].…”

Section: Discussioncontrasting

confidence: 99%

Diarrhea incidence and intestinal infections among rotavirus vaccinated infants from a poor area in Brazil: a spatial analysis

et al. 2014

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BackgroundAcute diarrhea is the second leading cause of mortality among children under 5 years of age in developing countries. The pathogen most strongly associated with diarrhea is rotavirus followed by enteric pathogens such as bacteria, helminthes and protozoan. Adequate sanitation and water supply contribute to decrease acute diarrhea incidence of most etiologic agents, although vaccination remains the most important intervention to control rotavirus acute diarrhea. This study aimed to describe environmental conditions and analyze spatially the acute diarrhea and intestinal infection among rotavirus vaccinated infants from Laranjeiras-Sergipe, Brazil.MethodsChildren were enrolled between 2 and 11 months of age and followed through 12 months. Demographic, socioeconomic and environmental data were obtained from a questionnaire, and immunization data were obtained from children vaccination card. Children stool samples were collected each month in order to run laboratory analyses. The household spatial localization was obtained by using a Global Positioning System (GPS). Spatial analysis was performed using the TerraView computer program and Kernel intensity estimation.ResultsA total of 1,113 stool samples were collected with 80 being diarrhea associated. Diarrhea incidence rate was 0.5 ± 1.0 episodes/child/year. The overall infection rates by Ascaris lumbricoides, Endolimax nana, Giardia lamblia and rotavirus were 5.1%, 3.0%, 0.9% and 2.6%, respectively. 3.8% of diarrhea-associated stool samples were positive for rotavirus and 11.3% were positive for helminths and protozoans. There were some changes on spatial distribution of intestinal infections and diarrhea episodes along the four trimesters evaluated.ConclusionsThe studied infants live equally in precarious conditions of sanitation which probably explain the significant rates of parasitic infections appearing in early life. The low acute diarrhea incidence in the studied rotavirus vaccinated population and the low number of symptomatic rotavirus infection may indicate vaccination efficacy to prevent acute diarrhea among young children in a poor environmental sanitary setting.

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Section: Discussioncontrasting

confidence: 99%

Diarrhea incidence and intestinal infections among rotavirus vaccinated infants from a poor area in Brazil: a spatial analysis

et al. 2014

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“…In countries with high vaccine coverage it has been observed that G2P [4] strains are very common in countries where Rotarix is used. [47][48][49] In other regions where RotaTeq is included in the vaccination schedule, the resurgence of G3P [8] strains has been documented. 50,51 At present, no definitive conclusion can be made to declare if such re-emergences of different strains in areas where different vaccines are used are associated with vaccination or merely reflect the natural spatiotemporal fluctuation of common co-circulating strains.…”

Section: Discussionmentioning

confidence: 99%

Surveillance of human rotaviruses in 2007–2011, Hungary: Exploring the genetic relatedness between vaccine and field strains

Békési

Kónya

Dandár

et al. 2012

Journal of Clinical Virology

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“…The medical importance of RVA is well established and, for this reason, since March of 2006, the Rotarix (r) vaccine has been included in the Brazilian National Immunisation Program (NIP). There has been a subsequent reduction in hospital admissions due to gastroenteritis in most regions of Brazil, most likely due to the efficacy of this vaccine ( Borges et al 2011 , do Carmo et al 2011 , Sandra et al 2013 ).…”

mentioning

confidence: 99%

The prevalence of norovirus, astrovirus and adenovirus infections among hospitalised children with acute gastroenteritis in Porto Velho, state of Rondônia, western Brazilian Amazon

Amaral

Estevam

Penatti

et al. 2015

Mem. Inst. Oswaldo Cruz

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Although viruses are well-established causes of acute gastroenteritis, few data on the circulation of these pathogens in Porto Velho, state of Rondônia, Brazil, are available. Thus, faecal samples from hospitalised diarrhoeic children, under six years of age, were collected and tested for the presence of norovirus (NoV), adenovirus (AdV) and astrovirus (AstV) from February 2010-February 2012. Specimens were screened by reverse-transcription polymerase chain reaction and viruses were found in 10.7% (63/591) of the cases. NoV, AdV and AstV were detected in 7.8%, 2% and 0.8% of the samples, respectively. NoV infection was observed at all ages and was most prevalent in zero-18-month-old children (84.7%; p = 0.002). A higher incidence of NoV was detected from February-April 2010, when it was found in 52.2% of the cases. Co-infections involving these viruses, rotavirus and enteropathogenic bacteria were detected in 44.4% (28/63) of the children with viral diarrhoea. Nosocomial infections were demonstrated in 28.6% (18/63) of the cases in which viruses were detected. The present paper reports, for the first time, the circulation of NoV and AstV among the paediatric population of Porto Velho and it contributes to our understanding of the roles of these pathogens in gastrointestinal infections.

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Monitoring the circulation of rotavirus among children after the introduction of the RotarixTM vaccine in Goiânia, Brazil

Cited by 14 publications

References 25 publications

Diarrhea incidence and intestinal infections among rotavirus vaccinated infants from a poor area in Brazil: a spatial analysis

Diarrhea incidence and intestinal infections among rotavirus vaccinated infants from a poor area in Brazil: a spatial analysis

Surveillance of human rotaviruses in 2007–2011, Hungary: Exploring the genetic relatedness between vaccine and field strains

The prevalence of norovirus, astrovirus and adenovirus infections among hospitalised children with acute gastroenteritis in Porto Velho, state of Rondônia, western Brazilian Amazon

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