Full-length genomic sequence of hepatitis B virus genotype C2 isolated from a native Brazilian patient

Alvarado-Mora, Mónica Viviana; Santana, Rúbia Anita Ferraz; Sitnik, Roberta; Ferreira, Paulo Roberto Abrão; Mangueira, Cristóvão Luis Pitangueira; Carrilho, Flair José; Pinho, João Renato Rebello

doi:10.1590/s0074-02762011000400017

Cited by 4 publications

(5 citation statements)

References 32 publications

(25 reference statements)

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“…Among them, B1 is found mainly in Japan, B2–5 in East Asia, and B6 in indigenous populations living in the Arctic, such as Alaska, Northern Canada and Greenland [8]. HBV genotype C (C1 to C5) is found throughout the eastern and southeastern portions of Asia and the Pacific islands (Micronesia, Melanesia, and Polynesia), as well as in immigrants from these areas in the United States, Europe, Australia, New Zealand [9] and Brazil [10]. HBV/D with subtypes D1–D5 is prevalent in the Mediterranean region expanding through South Asia up to India [8].…”

Section: Resultsmentioning

confidence: 99%

Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil

et al. 2013

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BackgroundHBV genotype F is primarily found in indigenous populations from South America and is classified in four subgenotypes (F1 to F4). Subgenotype F2a is the most common in Brazil among genotype F cases. The aim of this study was to characterize HBV genotype F2a circulating in 16 patients from São Paulo, Brazil. Samples were collected between 2006 and 2012 and sent to Hospital Israelita Albert Einstein. A fragment of 1306 bp partially comprising HBsAg and DNA polymerase coding regions was amplified and sequenced. Viral sequences were genotyped by phylogenetic analysis using reference sequences from GenBank (n=198), including 80 classified as subgenotype F2a. Bayesian Markov chain Monte Carlo simulation implemented in BEAST v.1.5.4 was applied to obtain the best possible estimates using the model of nucleotide substitutions GTR+G+I.FindingsIt were identified three groups of sequences of subgenotype F2a: 1) 10 sequences from São Paulo state; 2) 3 sequences from Rio de Janeiro and one from São Paulo states; 3) 8 sequences from the West Amazon Basin.ConclusionsThese results showing for the first time the distribution of F2a subgenotype in Brazil. The spreading and the dynamic of subgenotype F2a in Brazil requires the study of a higher number of samples from different regions as it is unfold in almost all Brazilian populations studied so far. We cannot infer with certainty the origin of these different groups due to the lack of available sequences. Nevertheless, our data suggest that the common origin of these groups probably occurred a long time ago.

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Section: Resultsmentioning

confidence: 99%

Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil

et al. 2013

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“…Five subgenotypes have been described; subgenotype C1 was found in Southeast Asia, C2 in East Asia, C3 in Polynesia, C4 in Aboriginal people from Australia, and C5 in the Philippines and Vietnam [23]. In Brazil, specifically in the states of São Paulo and Paraná, there was a great migration of descendants of East Asia, therefore, genotypes C (subgenotype C2) and B [24,25] are found in these regions.…”

Section: Genotypes B and Cmentioning

confidence: 99%

“…Genotypes B and C have also been found in São Paulo and Paraná states, generally in Asian-descent patients [24,59]. A case of genotype C infection was recently identified in a non-Asian-descent Brazilian women who had lived in Japan [25], emphasizing that the presence of rare genotypes in novel regions is frequently increasing due to globalization and the frequent and rapid travels around different world regions. Finally, one case of genotype H in Brazil has also been identified at Paraná, Southern Brazil, but it was not possible to identify the possible routes of transmission [59].…”

Section: Figure 2 Distribution Of Hbv Genotypes In Latin Americanmentioning

confidence: 99%

Distribution of HBV Genotypes in Latin America

Alvarado-Mora

Pinho

2005

Antiviral Therapy

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Approximately 2 billion people worldwide are infected with HBV, and 350 million people are chronic carriers. HBV is classified into nine genotypes (A to I). Genotype F is the most prevalent in the Spanish-speaking countries and in the Amerindian population in South America. HBV genotype F was primarily found in indigenous populations from South America and is divided into four subgenotypes (F1 to F4). Subgenotype F1 is further divided into F1a (found in Costa Rica and El Salvador) and F1b (found in in Alaska, Argentina and Chile). Subgenotypes F2 and F3 cocirculate in the north of South America: F2a is found in Brazil and Venezuela, F2b is described only in Venezuela, F3 is frequent in Colombia, Venezuela and Panama, and F4 is reported from the central and south areas of South America, including Bolivia, Argentina and southern Brazil. HBV genotypes and subgenotypes have distinct geographical distributions. It is currently under discussion whether they are associated with different prognoses, considering the patterns of severity of liver diseases in various populations. Furthermore, global human migrations affect the pattern of genotype distribution, introducing genotypes differing from those found in the original inhabitants.

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Section: Discussionmentioning

confidence: 99%

“…Genotype A is distributed globally, and is the main genotype found in sub-Saharan Africa, North America, India, Northern Europe, and Western Africa [ 45 , 46 ]. In Brazil, the most common genotype is A, followed by genotypes D and F [ 45 ]. Among the population of Japanese immigrants and their descendants living in São Paulo studied, HBV subgenotype A1, B1, C2, and F1b were found.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B Virus Infection among Japanese Immigrants and Descendants: The Need to Strengthen Preventive and Control Measures

Demarchi

Bandeira

Taira

et al. 2022

Viruses

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This cross-sectional study aimed to investigate the prevalence and risk factors of Hepatitis B virus infection among Japanese immigrants and their descendants from São Paulo (SP), and to verify the occurrence of occult hepatitis B and coinfection with HCV, Delta, and HTLV. All samples (n = 2.127) were tested for HBV serological markers by electrochemiluminescence. HBsAg and/or total anti-HBc positive samples were tested for HBV DNA by real-time PCR, and genotyped by sequencing using the Sanger methodology. The prevalence rate of HBV exposure was 13.4% (CI 95%: 11.9–14.9%), and 22 (1.1%) were HBsAg positive. A high rate of susceptibility to HBV infection was found (67.4%; CI 95%: 65.4–69.4%). In contrast, only 19.2% (CI 95%: 17.6–20.9%) presented a serological profile analogous to that elicited by Hepatitis B vaccination. HBV isolates (n = 8) were classified as genotypes HBV/B1 (62.5%), HBV/C2 (12.5%), HBV/F1b (12.5%), and HBV/A1 (12.5%). Hepatitis B vaccination strategies and educational measures to control this infection should be considered.

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Full-length genomic sequence of hepatitis B virus genotype C2 isolated from a native Brazilian patient

Cited by 4 publications

References 32 publications

Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil

Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil

Distribution of HBV Genotypes in Latin America

Hepatitis B Virus Infection among Japanese Immigrants and Descendants: The Need to Strengthen Preventive and Control Measures

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