Polymorphism analysis of the CTLA-4 gene in paracoccidioidomycosis patients

Lozano, Viviane Furlan; Lins, Tulio Cesar de Lima; Teixeira, Marcus de Melo; Vieira, Rodrigo G.; Blotta, Maria Heloı́sa Souza Lima; Góes, Alfredo M.; Silva, Izabel Cristina Rodrigues da; Pereira, Rinaldo Wellerson; Bocca, Anamélia Lorenzetti; Felipe, Maria Sueli Soares

doi:10.1590/s0074-02762011000200017

Cited by 9 publications

(4 citation statements)

References 44 publications

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“…However, Lozano et al [72] when studying the CTLA-4 gene polymorphisms that have been correlated with disfunctions of the immune response, associated it with susceptibility or resistance to Paracoccidioides. Another pair of receptors previously mentioned (CD28 and CD86) have been studied and found to be diminished in paracoccidioidomycosis patients as compared with heathy controls [73].…”

Section: Cells Of the Acquired Immunitymentioning

confidence: 99%

Paracoccidioidomycosis Protective Immunity

Burger

2021

JoF

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Protective immunity against Paracoccidioides consists of a stepwise activation of numerous effector mechanisms that comprise many cellular and soluble components. At the initial phase of non-specific innate immunity, resistance against Paracoccidioides comes from phagocytic polymorphonuclear neutrophils, natural killer (NK) cells and monocytes, supplemented by soluble factors such as cytokines and complement system components. Invariant receptors (Toll-like receptors (TLRs), Dectins) which are present in cells of the immune system, detect patterns present in Paracoccidioides (but not in the host) informing the hosts cells that there is an infection in progress, and that the acquired immunity must be activated. The role of components involved in the innate immunity of paracoccidioidomycosis is herein presented. Humoral immunity, represented by specific antibodies which control the fungi in the blood and body fluids, and its role in paracoccidioidomycosis (which was previously considered controversial) is also discussed. The protective mechanisms (involving various components) of cellular immunity are also discussed, covering topics such as: lysis by activated macrophages and cytotoxic T lymphocytes, the participation of lytic products, and the role of cytokines secreted by T helper lymphocytes in increasing the efficiency of Paracoccidioides, lysis.

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Section: Cells Of the Acquired Immunitymentioning

confidence: 99%

Paracoccidioidomycosis Protective Immunity

Burger

2021

JoF

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“…A polymorphism located at the promoter region of IL10 was also associated with PCM in a specific Brazilian population [ 96 ]. Variants at CTLA4, TNF and IFNG genes were not associated with PCM [ 94 , 96 , 97 ], but class I and class II HLA alleles were associated with PCM. The first studies demonstrated a higher frequency of HLA-A9 e HLA-B13 alleles in Colombian patients [ 98 ].…”

Section: Genetic Aspectsmentioning

confidence: 99%

Paracoccidioidomycosis: Current Perspectives from Brazil

et al. 2017

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Background:This review article summarizes and updates the knowledge on paracoccidioidomycosis. P lutzii and the cryptic species of P. brasiliensis and their geographical distribution in Latin America, explaining the difficulties observed in the serological diagnosis.Objectives:Emphasis has been placed on some genetic factors as predisposing condition for paracoccidioidomycosis. Veterinary aspects were focused, showing the wide distribution of infection among animals. The cell-mediated immunity was better characterized, incorporating the recent findings.Methods:Serological methods for diagnosis were also compared for their parameters of accuracy, including the analysis of relapse.Results:Clinical forms have been better classified in order to include the pictures less frequently observesiod.Conclusion:Itraconazole and the trimethoprim-sulfamethoxazole combination was compared regarding efficacy, effectiveness and safety, demonstrating that azole should be the first choice in the treatment of paracoccidioidomycosis.

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“…Several studies have reported an association of SNPs in genes related to immunity and increased susceptibility to infections, including PCM . Although there are many genes involved in immune response, we will focus on the following ones.…”

Section: Introductionmentioning

confidence: 99%

DC‐SIGN and VDR polymorphisms are associated with chronic form of paracoccidioidomycosis with oral manifestations

Neto

Pereira

Hanemann

et al. 2018

Mycoses

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Paracoccidioidomycosis (PCM) is a granulomatous disease caused by fungi of the species complex of the Paracoccidioides genus. One of the main clinical manifestations of PCM is the presence of oral lesions with the presence of epithelioid granulomas. In this work, we aimed to evaluate the frequency of SNPs in the TNF-α, JAK1, VDR, DC-SIGN and FcγRIIa genes in patients with chronic PCM and verify possible association of these SNPs with the organisation pattern of the granulomas in the oral lesions. A total of 66 samples of DNA were obtained from oral lesions biopsies and 106 DNA samples were obtained from healthy individuals. The individuals were genotyped for SNPs in DC-SIGN (rs4804803), FcγRIIa (rs1801274), JAK1 (rs11208534), TNF-α (rs1800629) and VDR (rs7975232) by real-time PCR and allele discrimination method. Granulomas were classified as loose or dense according to the histological pattern. In the VDR (rs7975232), the CC genotype (P < 0.001, OR = 5.94, 95% CI = 2.07-17.05), and the C allele (P = 0.027, OR = 2.71, 95% CI = 1.07-6.86), as well as the GG genotype in DC-SIGN (rs4804803) (P = 0.032, OR: 3.76, 95%, I = 1.06-13.38) are associated with an increased risk of oral PCM. Our data indicate that VDR and DC-SIGN genetics variations are related to the susceptibility of oral PCM in the group of patients analysed. K E Y W O R D S chronic paracoccidioidomycosis, DC-SIGN, single nucleotide polymorphism, VDR | 187 ALVES PEREIRA NETO ET AL.

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Polymorphism analysis of the CTLA-4 gene in paracoccidioidomycosis patients

Abstract: The CTLA-4 protein is expressed in activated T cells and plays an essential role in the immune

Cited by 9 publications

References 44 publications

Paracoccidioidomycosis Protective Immunity

Paracoccidioidomycosis Protective Immunity

Paracoccidioidomycosis: Current Perspectives from Brazil

DC‐SIGN and VDR polymorphisms are associated with chronic form of paracoccidioidomycosis with oral manifestations

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