The effects of nitric oxide on the immune system during Trypanosoma cruzi infection

Gutierrez, Fredy R. S.; Mineo, Tiago W. P.; Pavanelli, Wander Rogério; Guedes, Paulo Marcos da Matta; Silva, João

doi:10.1590/s0074-02762009000900030

Cited by 109 publications

(78 citation statements)

References 119 publications

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“…However, this prominent immune response mediated by innate cells and inflammatory cytokines (e.g., IFN-γ, IL-12, TNF-α, and CCL2), antibodies, and other molecules (e.g., nitric oxide) are necessary to repress parasite replication and invasion. [21][22][23] This acute stage is followed by a life-long chronic condition where the cellular immune response limits parasite proliferation despite being unable to eradicate the infection, which leads to a sustained and chronic inflammatory process. 24,25 The genetic characteristics of the parasites or hosts are pivotal aspects for the establishment of a diffuse cellular infiltration composed mainly of mononuclear cells and lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Enalapril in Combination with Benznidazole Reduces Cardiac Inflammation and Creatine Kinases in Mice Chronically Infected with Trypanosoma cruzi

Penitente¹,

Leite²,

Costa³

et al. 2015

The American Journal of Tropical Medicine and Hygiene

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Section: Discussionmentioning

confidence: 99%

Enalapril in Combination with Benznidazole Reduces Cardiac Inflammation and Creatine Kinases in Mice Chronically Infected with Trypanosoma cruzi

Penitente¹,

Leite²,

Costa³

et al. 2015

The American Journal of Tropical Medicine and Hygiene

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“…This effect is most likely attributed to the fact that NO reacts with the superoxide anion to form the peroxynitrite radical, a substance that is very harmful to the cell membrane 35 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of antioxidant therapy in experimental Chagas disease

Tieghi

Manca

Garcia

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction: Stimulation of inflammatory mediators such as cytokines and chemokines may cause oxidative stress in Chagas disease. In this study, we evaluated the merit of vitamins C and E as antioxidant therapy to minimize the oxidative stress-induced damage in an experimental model of Chagas disease. Methods: Ninety-six Swiss mice were infected with Trypanosoma cruzi QM2 and treated with vitamins C, E, or both (C/E) for 60 and 120 days, and their effects compared to placebo administration were evaluated in the acute and chronic disease phases. Results: There was no difference in parasitemia among treatment groups. However, histological analysis showed more severe inflammation in the skeletal muscle in the vitamin supplementation groups at both the acute and chronic phases. Biochemical analyses during the acute phase showed increased ferric-reducing ability of plasma (FRAP) and glutathione (GSH) levels in the vitamin C and C/E groups. In the chronic phase, a decrease in GSH levels was observed in the vitamin E group and a decrease in thiobarbituric acid reactive substances (TBARS) was observed in the vitamin C/E group. Moreover, there was a decrease in TBARS in the cardiac tissues of the vitamin C and C/E groups compared to that of the placebo group, although this level was greater in the vitamin E group than in the vitamin C group. Conclusions: The antioxidant action of vitamins C and E reduced oxidative stress in both the acute and chronic phases of Chagas disease, with a marked effect from joint administration, indicating their inherent synergism.

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“…The intensity of the inflammatory process and cytokines envolved will determine if NO participates as a microbicidal or immunosuppressive agent 21 .…”

Section: Discussionmentioning

confidence: 99%

Oral or topical administration of L-arginine changes the expression of TGF and iNOS and results in early wounds healing

et al. 2016

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Brazil. Design of the study, statistical analysis, analysis of data, manuscript writing. ABSTRACT PURPOSE:To evaluate the contribution of L-arginine oral or topical rout of administration in the surgical wound healing process.METHODS: L-arginine was orally or topically administrated to mice after a laparotomy model procedure. The wounds were analyzed to evaluate the granulation tissue by HE analysis, collagen deposition, iNOS and cytokines production by immunochemisyry on wound progress. Mice used in this model were healthy, immunosupressed or diabetic and all of them were treated with different concentration of L-arginine and rout of administration. RESULTS:Suggested that groups treated with L-arginine orally or topically improved wound repair when compared with non-treatad mice. L-arginine treatment stimulated TGF-β and restricted NO production leading to a mild Th1 response and collagen deposition in injured area, when it was orally administrated. Topical administration decreased IL-8 and CCR1 expression by wound cells but did not interfere with TNF-α and IL-10 production, ratifying the decrease of inflammatory response, the oral administration however, presented a higher iNOS and TGF-β expression then. L-arginine treatment also improved the improved the wound healing in immunosupressed or diabetic mice.CONCLUSION: L-arginine administrated orally or topically can be considered an important factor in the recuperation of tissues.

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The effects of nitric oxide on the immune system during Trypanosoma cruzi infection

Abstract: Trypanosoma cruzi infection triggers substantial production of nitric oxide (NO)

Cited by 109 publications

References 119 publications

Enalapril in Combination with Benznidazole Reduces Cardiac Inflammation and Creatine Kinases in Mice Chronically Infected with Trypanosoma cruzi

Enalapril in Combination with Benznidazole Reduces Cardiac Inflammation and Creatine Kinases in Mice Chronically Infected with Trypanosoma cruzi

Evaluation of antioxidant therapy in experimental Chagas disease

Oral or topical administration of L-arginine changes the expression of TGF and iNOS and results in early wounds healing

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