Structural organization of Trypanosoma cruzi

Souza, Wanderley de

doi:10.1590/s0074-02762009000900014

Cited by 66 publications

(47 citation statements)

References 53 publications

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“…A detailed description of the structures and functions can be found in specialized texts (103,437,438). Blood trypomastigotes and intracellular amastigotes are the T. cruzi forms encountered in mammalian hosts (Fig.…”

Section: Ultrastructure Genome Organization and Function Of Trypanomentioning

confidence: 99%

“…A complete description of morphological and functional properties of specialized structures and organelles of the T. cruzi epimastigote and trypomastigote stages has been reviewed elsewhere (103). Following cell invasion, the trypomastigotes are enclosed in a vacuole of lysosomal origin.…”

Section: Ultrastructure Genome Organization and Function Of Trypanomentioning

confidence: 99%

“…The kDNA comprises 15% to 30% of the total cellular DNA and differs from nuclear DNA in its buoyant density, base ratio, and degree of renaturation (103,104). Different from any other known DNAs, the kDNA of trypanosomatids is composed of circular molecules that are topologically relaxed and interlocked to form a single network.…”

Section: Kinetoplast Dnamentioning

confidence: 99%

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Pathogenesis of Chagas' Disease: Parasite Persistence and Autoimmunity

et al. 2011

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SUMMARY Acute Trypanosoma cruzi infections can be asymptomatic, but chronically infected individuals can die of Chagas' disease. The transfer of the parasite mitochondrial kinetoplast DNA (kDNA) minicircle to the genome of chagasic patients can explain the pathogenesis of the disease; in cases of Chagas' disease with evident cardiomyopathy, the kDNA minicircles integrate mainly into retrotransposons at several chromosomes, but the minicircles are also detected in coding regions of genes that regulate cell growth, differentiation, and immune responses. An accurate evaluation of the role played by the genotype alterations in the autoimmune rejection of self-tissues in Chagas' disease is achieved with the cross-kingdom chicken model system, which is refractory to T. cruzi infections. The inoculation of T. cruzi into embryonated eggs prior to incubation generates parasite-free chicks, which retain the kDNA minicircle sequence mainly in the macrochromosome coding genes. Crossbreeding transfers the kDNA mutations to the chicken progeny. The kDNA-mutated chickens develop severe cardiomyopathy in adult life and die of heart failure. The phenotyping of the lesions revealed that cytotoxic CD45, CD8 + γδ, and CD8α + T lymphocytes carry out the rejection of the chicken heart. These results suggest that the inflammatory cardiomyopathy of Chagas' disease is a genetically driven autoimmune disease.

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Section: Ultrastructure Genome Organization and Function Of Trypanomentioning

confidence: 99%

Section: Ultrastructure Genome Organization and Function Of Trypanomentioning

confidence: 99%

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Pathogenesis of Chagas' Disease: Parasite Persistence and Autoimmunity

et al. 2011

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“…Classic examples of asymmetrical divisions are found in the early development of some embryos, such as in Caenorhabditis elegans (Hyman and White, 1987), whereas the production of identical progeny is characteristic of tissue growth and is often exquisitely seen in the protists . In the unicellular eukaryotes, the fidelity of the processes whereby the cytoskeletal and membrane components of the cell are duplicated is so well orchestrated and linked to cell morphogenesis that the resulting cells and populations can be identified purely on morphological grounds (Aly et al, 2009;de Souza, 2009;Svard et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Basal body movements orchestrate membrane organelle division and cell morphogenesis inTrypanosoma brucei

Lacomble

Vaughan

Gadelha

et al. 2010

Journal of Cell Science

144

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SummaryThe defined shape and single-copy organelles of Trypanosoma brucei mean that it provides an excellent model in which to study how duplication and segregation of organelles is interfaced with morphogenesis of overall cell shape and form. The centriole or basal body of eukaryotic cells is often seen to be at the centre of such processes. We have used a combination of electron microscopy and electron tomography techniques to provide a detailed three-dimensional view of duplication of the basal body in trypanosomes. We show that the basal body duplication and maturation cycle exerts an influence on the intimately associated flagellar pocket membrane system that is the portal for secretion and uptake from this cell. At the start of the cell cycle, a probasal body is positioned anterior to the basal body of the existing flagellum. At the G1-S transition, the probasal body matures, elongates and invades the pre-existing flagellar pocket to form the new flagellar axoneme. The new basal body undergoes a spectacular anti-clockwise rotation around the old flagellum, while its short new axoneme is associated with the pre-existing flagellar pocket. This rotation and subsequent posterior movements results in division of the flagellar pocket and ultimately sets parameters for subsequent daughter cell morphogenesis.

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“…Uma característica observada na ultraestrutura dos flagelados de plantas, que pode ser típica do gênero Phytomonas, é a quantidade acentuada de glicossomos (De Souza, 2009) que pode estar relacionada à ausência de um ciclo de Krebs funcional nas mitocôndrias e, portanto, à produção de ATP (Adenosina Trifosfato) pela via glicolítica dos glicossomos (Chaumont et al, 1994).…”

Section: Estudos De Microscopia De Luz E Eletrônica Demonstram Que Punclassified

Diversidade, relações filogenéticas e taxonomia de Phytomonas spp.

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Structural organization of Trypanosoma cruzi

Abstract: Since the initial description of

Cited by 66 publications

References 53 publications

Pathogenesis of Chagas' Disease: Parasite Persistence and Autoimmunity

Pathogenesis of Chagas' Disease: Parasite Persistence and Autoimmunity

Basal body movements orchestrate membrane organelle division and cell morphogenesis inTrypanosoma brucei

Diversidade, relações filogenéticas e taxonomia de Phytomonas spp.

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