Elimination of Chagas disease transmission: perspectives

Dias, João Carlos Pinto

doi:10.1590/s0074-02762009000900007

Cited by 102 publications

(101 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Chagas disease (ChD), a neglected tropical disease caused by infection with the parasite Trypanosoma cruzi (T. cruzi) (1) (2) , remains a serious health problem issue in Latin America and is an emerging disease in several non-endemic countries, where knowledge of the condition and experience with its clinical management are limited. If ChD is not recognized and treated appropriately, patient care can be compromised.…”

Section: Introductionmentioning

confidence: 99%

Health-related quality of life in patients with Chagas disease: a review of the evidence

Sousa

Costa

Souza

et al. 2015

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Chagas disease (ChD), a neglected tropical disease caused by infection with the parasite Trypanosoma cruzi (T. cruzi), remains a serious p ublic health issue in Latin America and is an emerging disease in several non-endemic countries, where knowledge of the condition and experience with its clinical management are limited. Regionally, the disease is the major cause of disability secondary to tropical diseases in young adults. Health-related quality of life (HRQoL) impairment is common in patients with ChD, especially in those with Chagas dilated cardiomyopathy, the most severe manifestation of the disease, which frequently leads to heart failure. The aim of this review was to conduct a literature search for studies that have evaluated the determining factors of HRQoL in ChD patients. We included cross-sectional, case-control, cohort, and experimental studies, as well as clinical trials that evaluated the HRQoL in ChD patients aged 18 to 60 years and are presenting an explicit description of statistical analysis. Using a combination of keywords based on Descriptors in Health Sciences (DeCS) and Medical Subject Headings (MeSH) for searches in PubMed and the Scientifi c Electronic Library Online (SciELO), 148 studies were found. After exclusions, 12 studies were selected for analysis. Three main fi ndings were extracted from these studies: 1) cardiac involvement is associated with a worse HRQoL in ChD patients; 2) HRQoL is associated with the patients' functional capacity; and 3) simple and inexpensive therapeutic measures are effective for improving HRQoL in ChD patients. Hence, ChD patients' functional capacity, the effectiveness of non-surgical conservative treatment, and cardiac involvement are important determining factors for the HRQoL in ChD patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Health-related quality of life in patients with Chagas disease: a review of the evidence

Sousa

Costa

Souza

et al. 2015

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

show abstract

“…Also, congenital, transfusional, and oral transmissions occur. 1 Its clinical manifestations initiate with a short acute phase characterized by high parasitemia and various symptoms such as myocarditis. After the development of an acquired immune response during the chronic phase, the parasite numbers decrease in the bloodstream and tissues, remaining very low for most Chagasic patients.…”

Section: Introductionmentioning

confidence: 99%

Intraspecies Variation in Trypanosoma cruzi GPI-Mucins: Biological Activities and Differential Expression of α-Galactosyl Residues

Soares¹,

Torrecilhas²,

Assis³

et al. 2012

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…Early diagnosis of the disease is difficult due to its clinical characteristics, and treatment for chronic strains is not always effective (DE ANDRADE et al 1996;SOSA et al 1998). The parasite was first identified by the Brazilian infectologist Carlos Chagas in 1909, but it was not until the 1960s that disease control programs were first established (ABAD FRANCH et al 2011;DIAS 2009;SILVEIRA 2002). Rural migration to urban areas in the 1960s and the 1970s increased the risk of contracting the disease, while recent large-scale migration has led to the further spread of the disease to a number of other countries worldwide (GASCON et al 2010;MUÑOZ et al 2009;JACKSON et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Scientific authorships and collaboration network analysis on Chagas disease: papers indexed in PubMed (1940-2009)

González‐Alcaide

Park

Huamaní

et al. 2012

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

SUMMARYChagas disease is a chronic, tropical, parasitic disease, endemic throughout Latin America. The large-scale migration of populations has increased the geographic distribution of the disease and cases have been observed in many other countries around the world. To strengthen the critical mass of knowledge generated in different countries, it is essential to promote cooperative and translational research initiatives. We analyzed authorship of scientific documents on Chagas disease indexed in the Medline database from 1940 to 2009. Bibliometrics was used to analyze the evolution of collaboration patterns. A Social Network Analysis was carried out to identify the main research groups in the area by applying clustering methods. We then analyzed 13,989 papers produced by 21,350 authors. Collaboration among authors dramatically increased over the study period, reaching an average of 6.2 authors per paper in the last five-year period. Applying a threshold of collaboration of five or more papers signed in co-authorship, we identified 148 consolidated research groups made up of 1,750 authors. The Chagas disease network identified constitutes a "small world," characterized by a high degree of clustering and a notably high number of Brazilian researchers.

show abstract

Elimination of Chagas disease transmission: perspectives

Cited by 102 publications

References 16 publications

Health-related quality of life in patients with Chagas disease: a review of the evidence

Health-related quality of life in patients with Chagas disease: a review of the evidence

Intraspecies Variation in Trypanosoma cruzi GPI-Mucins: Biological Activities and Differential Expression of α-Galactosyl Residues

Scientific authorships and collaboration network analysis on Chagas disease: papers indexed in PubMed (1940-2009)

Contact Info

Product

Resources

About