Anti-mycobacterial treatment reduces high plasma levels of CXC-chemokines detected in active tuberculosis by cytometric bead array

Almeida, Caroline de Souza; Abramo, Clarice; Alves, Caio César de Souza; Mazzoccoli, Luciano; Ferreira, Ana Paula; Teixeira, Henrique Couto

doi:10.1590/s0074-02762009000700018

Cited by 24 publications

(13 citation statements)

References 11 publications

(13 reference statements)

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“…Similarly, MIP-1α, MIP-1β, and RANTES (namely CCL3, CCL4, and CCL5) play key roles in Helicobacter pylori (Raghavan et al, 2003). Moreover, CXC chemokines are involved in various bacterial infections by impacting neutrophils, for example, P. aeruginosa, M. tuberculosis (Almeida et al, 2009; Gregson et al, 2013). In this study, we found infiltrated cells in the lungs are mainly the neutrophils, with lower number of macrophages in pulmonary lesion, suggesting that CXC chemokines have critical roles during P. multocida infection.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic Analysis on Responses of Murine Lungs to Pasteurella multocida Infection

Qin

et al. 2017

Front. Cell. Infect. Microbiol.

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Pasteurella multocida infection in cattle causes serious epidemic diseases and leads to great economic losses in livestock industry; however, little is known about the interaction between host and P. multocida in the lungs. To explore a fully insight into the host responses in the lungs during P. multocida infection, a mouse model of Pasteurella pneumonia was established by intraperitoneal infection, and then transcriptomic analysis of infected lungs was performed. P. multocida localized and grew in murine lungs, and induced inflammation in the lungs, as well as mice death. With transcriptomic analysis, approximately 107 clean reads were acquired. 4236 differently expressed genes (DEGs) were detected during P. multocida infection, of which 1924 DEGs were up-regulated. By gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) enrichments, 5,303 GO enrichments and 116 KEGG pathways were significantly enriched in the context of P. multocida infection. Interestingly, genes related to immune responses, such as pattern recognition receptors (PRRs), chemokines and inflammatory cytokines, were significantly up-regulated, suggesting the key roles of these genes in P. multocida infection. Transcriptomic data showed that IFN-γ/IL-17-related genes were increased, which were validated by qRT-PCR, ELISA, and immunoblotting. Our study characterized the transcriptomic profile of the lungs in mice upon Pasteurella infection, and our findings could provide valuable information with respect to better understanding the responses in mice during P. multocida infection.

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Section: Discussionmentioning

confidence: 99%

Transcriptomic Analysis on Responses of Murine Lungs to Pasteurella multocida Infection

Qin

et al. 2017

Front. Cell. Infect. Microbiol.

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“…Whether CXCL8 is associated with a protective or pathologic response remains controversial (437, 438). Serum CXCL8 levels from pulmonary TB patients following treatment with antibiotics decreases suggesting that CXCL8 could be a marker for treatment efficacy (439). Whether disease improvement is directly correlated to reduced CXCL8 levels or simply a reflection of reduced neutrophil accumulation is unclear (Figure 1).…”

Section: The Chemokinesmentioning

confidence: 99%

“…Human data support a protective role for CXCR3-binding chemokines as CXCL9 levels correlate with disease severity (379, 450) although the role of CXCL10 is unclear. CXCL10 has been proposed as a biomarker for improvement, as reduction of this chemokine in the serum relative to levels at recruitment is observed following TB treatment and non-responders do not show the same decrease (439, 451). Unfortunately, CXCL10 levels cannot distinguish between active and latent TB in children (452).…”

Section: The Chemokinesmentioning

confidence: 99%

Cytokines and Chemokines inMycobacterium tuberculosisInfection

et al. 2016

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Chemokines and cytokines are critical for initiating and coordinating the organized and sequential recruitment and activation of cells into Mycobacterium tuberculosis -infected lungs. Correct mononuclear cellular recruitment and localization are essential to ensure control of bacterial growth without the development of diffuse and damaging granulocytic inflammation. An important block to our understanding of TB pathogenesis lies in dissecting the critical aspects of the cytokine/chemokine interplay in light of the conditional role these molecules play throughout infection and disease development. Much of the data highlighted in this review appears at first glance to be contradictory, but it is the balance between the cytokines and chemokines that is critical, and the “goldilocks” (not too much and not too little) phenomenon is paramount in any discussion of the role of these molecules in TB. Determination of how the key chemokines/cytokines and their receptors are balanced and how the loss of that balance can promote disease is vital to understanding TB pathogenesis and to identifying novel therapies for effective eradication of this disease.

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“…Whether CXCL8 is associated with a protective or pathologic response remains controversial (437,438). Serum CXCL8 levels from pulmonary TB patients following treatment with antibiotics decreased, suggesting that CXCL8 could be a marker for treatment efficacy (439). Whether disease improvement is directly correlated to reduced CXCL8 levels or simply a reflection of reduced neutrophil accumulation is unclear (Fig.…”

Section: Receptors and Their Ligands Cxcr1 And Cxcr2mentioning

confidence: 99%

Cytokines and Chemokines inMycobacterium tuberculosisInfection

Domingo-Gonzalez

Prince

Cooper

et al. 2017

Tuberculosis and the Tubercle Bacillus

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Chemokines and cytokines are critical for initiating and coordinating the organized and sequential recruitment and activation of cells into Mycobacterium tuberculosis-infected lungs. Correct mononuclear cellular recruitment and localization are essential to ensure control of bacterial growth without the development of diffuse and damaging granulocytic inflammation. An important block to our understanding of TB pathogenesis lies in dissecting the critical aspects of the cytokine/chemokine interplay in light of the conditional role these molecules play throughout infection and disease development. Much of the data highlighted in this review appears at first glance to be contradictory, but it is the balance between the cytokines and chemokines that is critical, and the "goldilocks" (not too much and not too little) phenomenon is paramount in any discussion of the role of these molecules in TB. Determination of how the key chemokines/cytokines and their receptors are balanced and how the loss of that balance can promote disease is vital to understanding TB pathogenesis and to identifying novel therapies for effective eradication of this disease.

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Anti-mycobacterial treatment reduces high plasma levels of CXC-chemokines detected in active tuberculosis by cytometric bead array

Cited by 24 publications

References 11 publications

Transcriptomic Analysis on Responses of Murine Lungs to Pasteurella multocida Infection

Transcriptomic Analysis on Responses of Murine Lungs to Pasteurella multocida Infection

Cytokines and Chemokines inMycobacterium tuberculosisInfection

Cytokines and Chemokines inMycobacterium tuberculosisInfection

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