Modification of oxidative status in Plasmodium berghei-infected erythrocytes by E-2-chloro-8-methyl-3-[(4'-methoxy-1'-indanoyl)-2'-methyliden]-quinoline compared to chloroquine

Anti-Plasmodial Phytochemical Agents - The Effective Alternative for Drug-Resistant Plasmodial Control

“…Previous studies have also shown that the overall activity of SOD is decreased due to the infection in Plasmodium falciparum, Plasmodium knowlesi and Plasmodium berghei-infected cells. [47,48] The loss of the activity of first line of antioxidant enzymes could be due to their entry from the erythrocyte cytoplasm to the digestive vacuole in the parasite via endocytosis. [49] Indeed, in the acidic environment the enzymes could be inactivated, which would increase the levels of free radicals in the infected-erythrocyte, promoting oxidative stress.…”