Delay in maturation of the submandibular gland in Chagas disease correlates with lower DNA synthesis

Alves, José Bento; Napimoga, Marcelo Henrique; Araújo, Marcelo Sivieri de; Silva, Gerluza A.B.

doi:10.1590/s0074-02762008000600012

Cited by 2 publications

(1 citation statement)

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“…However, it is has been demonstrated that Chagas' disease can also induce alterations in the oral cavity tissues such as parotid glands , submandibular glands (Moreira et al 2008;Alves et al 2008), and in the tongue (de Lima Pereira et al 2006;de Lima Pereira et al 2007). Our group previously described a positive and significant correlation between fibrosis and mast cell infiltration in the tongue of Chagasic patients.…”

Section: Introductionmentioning

confidence: 99%

Expression of cytokines and chemokines and microvasculature alterations of the tongue from patients with chronic Chagas’ disease

et al. 2009

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Chagas' disease is caused by the protozoan Trypanosoma cruzi and continues to be a significant public health problem, since 10 million people are still infected in Latin America. The purpose of this study was to analyze the microvasculature alterations as well the expression of cytokines and chemokines in the tongues from patients with chronic Chagas' disease (CC; n = 18), comparatively with a non-chagasic group (NC; n = 22). We observed several vascular alterations in the tongue of CC such as a greater vascular diameter, increased vascular wall area, high density of the blood vessels, and increased thickening of the capillary basement membrane. The expression of cytokines interferon gamma and tumor necrosis factor alpha and chemokine macrophage inflammatory protein 1alpha were significantly down-regulated in the tongue of CC group. These results demonstrated that, in the tongue of chagasic patients, a microvascular abnormality and immunological impairment occurs, probably due to chronic inflammation evoked by T. cruzi antigens.

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Section: Introductionmentioning

confidence: 99%